SLC7A5

;関:large neutral amino acid-transporter 1

関

large neutral amino acid-transporter 1

• large neutral amino acid-transporter 1

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/20 13:52:12」(JST)

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Solute carrier family 7 (amino acid transporter light chain, L system), member 5
Identifiers
Symbols	SLC7A5; 4F2LC; CD98; D16S469E; E16; LAT1; MPE16; hLAT1
External IDs	OMIM: 600182 MGI: 1298205 HomoloGene: 55759 ChEMBL: 4459 GeneCards: SLC7A5 Gene
Gene Ontology Molecular function • amino acid transmembrane transporter activity • neutral amino acid transmembrane transporter activity • L-amino acid transmembrane transporter activity • peptide antigen binding Cellular component • cytosol • plasma membrane • integral to membrane • apical plasma membrane Biological process • cellular amino acid metabolic process • transport • ion transport • amino acid transport • nervous system development • blood coagulation • neutral amino acid transport • cell differentiation • leukocyte migration • transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8140	20539
Ensembl	ENSG00000103257	ENSMUSG00000040010
UniProt	Q01650	Q9Z127
RefSeq (mRNA)	NM_003486	NM_011404
RefSeq (protein)	NP_003477	NP_035534
Location (UCSC)	Chr 16: 87.86 – 87.9 Mb	Chr 8: 121.88 – 121.91 Mb
PubMed search	[1]	[2]

Solute carrier family 7 member 5 also known as large neutral amino acids transporter small subunit 1 is a protein that in humans is encoded by the SLC7A5 gene.

See also

• Heterodimeric amino acid transporter

References

Further reading

• Kaira K, Oriuchi N, Imai H, et al. (2009). "Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma.". Lung Cancer 66 (1): 120–6. doi:10.1016/j.lungcan.2008.12.015. PMID 19171406. 
• Verrey F, Jack DL, Paulsen IT, et al. (1999). "New glycoprotein-associated amino acid transporters.". J. Membr. Biol. 172 (3): 181–92. doi:10.1007/s002329900595. PMID 10568788. 
• Nawashiro H, Otani N, Shinomiya N, et al. (2006). "L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors.". Int. J. Cancer 119 (3): 484–92. doi:10.1002/ijc.21866. PMID 16496379. 
• Nawashiro H, Otani N, Uozumi Y, et al. (2005). "High expression of L-type amino acid transporter 1 in infiltrating glioma cells.". Brain Tumor Pathol 22 (2): 89–91. doi:10.1007/s10014-005-0188-z. PMID 18095110. 
• Ohno Y, Suda K, Masuko K, et al. (2008). "Production and characterization of highly tumor-specific rat monoclonal antibodies recognizing the extracellular domain of human L-type amino-acid transporter 1.". Cancer Sci. 99 (5): 1000–7. doi:10.1111/j.1349-7006.2008.00770.x. PMID 18294274. 
• Vumma R, Wiesel FA, Flyckt L, et al. (2008). "Functional characterization of tyrosine transport in fibroblast cells from healthy controls.". Neurosci. Lett. 434 (1): 56–60. doi:10.1016/j.neulet.2008.01.028. PMID 18262359. 
• Endou H, Kanai Y (1999). "[Amino acid transporter molecule as a drug target]". Nippon Yakurigaku Zasshi. 114 Suppl 1: 11P–16P. PMID 10629848. 
• Nakanishi K, Ogata S, Matsuo H, et al. (2007). "Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract.". Virchows Arch. 451 (3): 681–90. doi:10.1007/s00428-007-0457-9. PMID 17622555. 
• Kaira K, Oriuchi N, Imai H, et al. (2009). "L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas.". J Surg Oncol 99 (7): 433–8. doi:10.1002/jso.21277. PMID 19347882. 
• Anderson BM, Schnetz-Boutaud NC, Bartlett J, et al. (2009). "Examination of association of genes in the serotonin system to autism.". Neurogenetics 10 (3): 209–16. doi:10.1007/s10048-009-0171-7. PMID 19184136. 
• Ring BZ, Seitz RS, Beck RA, et al. (2009). "A novel five-antibody immunohistochemical test for subclassification of lung carcinoma.". Mod. Pathol. 22 (8): 1032–43. doi:10.1038/modpathol.2009.60. PMID 19430419. 
• Kaira K, Oriuchi N, Imai H, et al. (2008). "Expression of L-type amino acid transporter 1 (LAT1) in neuroendocrine tumors of the lung.". Pathol. Res. Pract. 204 (8): 553–61. doi:10.1016/j.prp.2008.02.003. PMID 18440724. 
• Kobayashi K, Ohnishi A, Promsuk J, et al. (2008). "Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells.". Neurosurgery 62 (2): 493–503; discussion 503–4. doi:10.1227/01.neu.0000316018.51292.19. PMID 18382329. 
• Kühne A, Kaiser R, Schirmer M, et al. (2007). "Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan.". Pharmacogenet. Genomics 17 (7): 505–17. doi:10.1097/FPC.0b013e3280ea77cd. PMID 17558306. 
• Kaira K, Oriuchi N, Imai H, et al. (2008). "Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer.". Br. J. Cancer 98 (4): 742–8. doi:10.1038/sj.bjc.6604235. PMID 18253116. 
• Bröer S (2008). "Amino acid transport across mammalian intestinal and renal epithelia.". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088. 
• Kaira K, Oriuchi N, Imai H, et al. (2008). "l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms.". Cancer Sci. 99 (12): 2380–6. doi:10.1111/j.1349-7006.2008.00969.x. PMID 19018776. 
• Imai H, Kaira K, Oriuchi N, et al. (2009). "L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer.". Histopathology 54 (7): 804–13. doi:10.1111/j.1365-2559.2009.03300.x. PMID 19635099. 
• Shennan DB, Thomson J (2008). "Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells.". Oncol. Rep. 20 (4): 885–9. PMID 18813831. 
• Sakata T, Ferdous G, Tsuruta T, et al. (2009). "L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer.". Pathol. Int. 59 (1): 7–18. doi:10.1111/j.1440-1827.2008.02319.x. PMID 19121087. 

English Journal

• Dexamethasone Downregulates SLC7A5 Expression and Promotes Cell Cycle Arrest, Autophagy and Apoptosis in BeWo Cells.

• He B1, Zhang N1, Zhao R1.
• Journal of cellular physiology.J Cell Physiol.2016 Jan;231(1):233-42. doi: 10.1002/jcp.25076.
• Synthetic glucocorticoids (GCs) such as dexamethasone (Dex) are widely given to pregnant women to induce maturation and improve viability of preterm infants. Despite the beneficial effects, synthetic GCs have adverse effects on placental growth and nutrient transport system. However, the molecular m
• PMID 26094588

• Deficiency in the α1 subunit of Naa+/K+-ARPase enhances the anti-proliferative effect of high osmolality in nucleus pulposus intervertebral disc cells.

• Mavrogonatou E1, Papadimitriou K2, Urban JP3, Papadopoulos V4, Kletsas D1.
• Journal of cellular physiology.J Cell Physiol.2015 Dec;230(12):3037-48. doi: 10.1002/jcp.25040.
• Intervertebral disc cells are constantly exposed to a hyperosmotic environment. Among cellular responses towards this stress is the inhibition of proliferation through the activation of p38 MAPK and p53. In an effort to further elucidate the biochemical pathways triggered by hyperosmotic stress, we
• PMID 25967398

• Piperine metabolically regulates peritoneal resident macrophages to potentiate their functions against bacterial infection.

• Pan H1, Xu LH2, Huang MY1, Zha QB3, Zhao GX1, Hou XF1, Shi ZJ3, Lin QR1, Ouyang DY1, He XH1.
• Oncotarget.Oncotarget.2015 Oct 2. [Epub ahead of print]
• Pepper, a daily-used seasoning for promoting appetite, is widely used in folk medicine for treating gastrointestinal diseases. Piperine is the major alkaloid in pepper and possesses a wide range of pharmacological activities. However, the mechanism for linking metabolic and medicinal activities of p
• PMID 26439699

Japanese Journal

• アミノ酸トランスポーターを標的とした癌デリバリー

• 金井 好克
• Drug Delivery System 27(5), 342-349, 2012
• … 腫瘍細胞に高発現するアミノ酸トランスポーターのうち、LAT1 (SLC7A5)は、腫瘍選択的な発現と広い基質選択性を示し、癌への薬物送達の標的トランスポーターとして好ましい性質を有している。 …
• NAID 130003368325

• Evaluation of Amino Acid-Mustard Transport as L-Type Amino Acid Transporter 1 (LAT1)-Mediated Alkylating Agents(Biopharmacy)

• Hosoya Ken-ichi,Kyoko Hirokazu,Toyooka Naoki [他],KATO Atsushi,ORIHASHI Masahiro,TOMI Masatoshi,TACHIKAWA Masanori
• Biological & pharmaceutical bulletin 31(11), 2126-2130, 2008-11-01
• … The L-type amino acid transporter 1 (LAT1, SLC7A5) is an Na^+ -independent neutral amino acid transporter the expression of which is located in retinal endothelial cells. …
• NAID 110006968099

Related Links

• SLC7A5 Gene - GeneCards | LAT1 Protein | LAT1 Antibody

Complete information for SLC7A5 gene (protein-coding), solute carrier family 7 (amino acid transporter light chain, L system), member 5, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ...

• SLC7A5 solute carrier family 7 (amino acid transporter light ...

Gene provides a unified query environment for genes defined by sequence and/or in NCBI's Map Viewer. ... Gene ID: 8140, updated on 6-Oct-2013 Summary Other designations 4F2 LC, 4F2 light chain, CD98 light chain, L-type amino acid transporter 1 ...

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リンク元	「large neutral amino acid-transporter 1」

「large neutral amino acid-transporter 1」

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大型中性アミノ酸輸送体1、大型中性アミノ酸トランスポータ1

関

LAT1、SLC7A5