SLC7A2

• cationic amino acid transporter 2

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/14 02:10:28」(JST)

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Solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Identifiers
Symbols	SLC7A2; ATRC2; CAT2; HCAT2
External IDs	OMIM: 601872 MGI: 99828 HomoloGene: 20659 GeneCards: SLC7A2 Gene
Gene Ontology Molecular function • L-ornithine transmembrane transporter activity • high affinity arginine transmembrane transporter activity • basic amino acid transmembrane transporter activity • L-lysine transmembrane transporter activity Cellular component • cytoplasm • plasma membrane • integral to plasma membrane • membrane Biological process • nitric oxide production involved in inflammatory response • cellular amino acid metabolic process • nitric oxide biosynthetic process • transport • ion transport • amino acid transport • macrophage activation • regulation of inflammatory response • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6542	11988
Ensembl	ENSG00000003989	ENSMUSG00000031596
UniProt	P52569	P18581
RefSeq (mRNA)	NM_001008539.3	NM_001044740.1
RefSeq (protein)	NP_001008539.3	NP_001038205.1
Location (UCSC)	Chr 8: 17.35 – 17.43 Mb	Chr 8: 40.86 – 40.92 Mb
PubMed search	[1]	[2]

Low affinity cationic amino acid transporter 2 is a protein that in humans is encoded by the SLC7A2 gene.

See also

• SLC7A2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

References

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129/.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
• González M, Flores C, Pearson JD, et al. (2005). "Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells.". Pflugers Arch. 448 (4): 383–94. doi:10.1007/s00424-004-1261-x. PMID 15064952.
• Schnorr O, Suschek CV, Kolb-Bachofen V (2003). "The importance of cationic amino acid transporter expression in human skin.". J. Invest. Dermatol. 120 (6): 1016–22. doi:10.1046/j.1523-1747.2003.12139.x. PMID 12787129.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
• Hammermann R, Brunn G, Racké K (2002). "Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4.". Amino Acids 21 (2): 211–9. doi:10.1007/s007260170029. PMID 11665818.
• Closs EI, Gräf P, Habermeier A, et al. (1997). "Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties.". Biochemistry 36 (21): 6462–8. doi:10.1021/bi962829p. PMID 9174363.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

English Journal

• Comparative pharmacokinetics of rhein in normal and loperamide-induced constipated rats and microarray analysis of drug-metabolizing genes.

• Hou ML1, Chang LW1, Lin CH2, Lin LC3, Tsai TH4.
• Journal of ethnopharmacology.J Ethnopharmacol.2014 Sep 11;155(2):1291-9. doi: 10.1016/j.jep.2014.07.022. Epub 2014 Jul 19.
• ETHNOPHARMACOLOGICAL RELEVANCE: Rhein is a pharmacological active component found in Rheum palmatum L. that is the major herb of the San-Huang-Xie-Xin-Tang (SHXXT), a medicinal herbal product used as a remedy for constipation. Here we have investigated the comparative pharmacokinetics of rhein in no
• PMID 25046826

• Amino acids in the uterine luminal fluid reflects the temporal changes in transporter expression in the endometrium and conceptus during early pregnancy in cattle.

• Forde N1, Simintiras CA2, Sturmey R2, Mamo S1, Kelly AK2, Spencer TE3, Bazer FW4, Lonergan P1.
• PloS one.PLoS One.2014 Jun 24;9(6):e100010. doi: 10.1371/journal.pone.0100010. eCollection 2014.
• In cattle, conceptus-maternal interactions are critical for the establishment and maintenance of pregnancy. A major component of this early interaction involves the transport of nutrients and secretion of key molecules by uterine epithelial cells to help support conceptus development during the peri
• PMID 24960174

• Identification of cysteine residues in human cationic amino acid transporter hCAT-2A that are targets for inhibition by N-ethylmaleimide.

• Beyer SR1, Mallmann RT, Jaenecke I, Habermeier A, Boissel JP, Closs EI.
• The Journal of biological chemistry.J Biol Chem.2013 Oct 18;288(42):30411-9. doi: 10.1074/jbc.M113.490698. Epub 2013 Sep 9.
• In most cells, cationic amino acids such as l-arginine, l-lysine, and l-ornithine are transported by cationic (CAT) and y(+)L (y(+)LAT) amino acid transporters. In human erythrocytes, the cysteine-modifying agent N-ethylmaleimide (NEM) has been shown to inhibit system y(+) (most likely CAT-1), but n
• PMID 24019517

Japanese Journal

• Select Nutrients in the Uterine Lumen of Sheep and Pigs Affect Conceptus Development

• , , [他], , ,
• The Journal of reproduction and development 58(2), 180-188, 2012-04-01
• … In ewes, Arg and Gluc increase significantly in the uterine lumen between Days 10 and 15 of pregnancy due to increased expression of transporters for Gluc (SLC2A1 and SLC5A1) and Arg (SLC7A2B) by uterine epithelia. … Transporters for glutamate and neutral (SLC1A1, SLC1A4) and cationic (SLC7A1, SLC7A2, SLC7A7, SLC7A9) amino acids are expressed in uterine LE and SLC7A3 mRNA is expressed in conceptus Tr. …
• NAID 10030753562

Related Links

• SLC7A2 Gene - GeneCards | CTR2 Protein | CTR2 Antibody

Complete information for SLC7A2 gene (protein-coding), solute carrier family 7 (cationic amino acid transporter, y+ system), member 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ...

• SLC7A2 - Gene Page | Sigma-Aldrich

The gene SLC7A2 may have Genomic and Proteomic products available from Sigma-Aldrich. ... Gene ID: Human(6542) Summary: The protein encoded by this gene is a cationic amino acid transporter and a member of the APC ...

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