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SLC2A5 |
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Identifiers |
Aliases |
SLC2A5, GLUT-5, GLUT5, solute carrier family 2 member 5 |
External IDs |
MGI: 1928369 HomoloGene: 74459 GeneCards: SLC2A5 |
Gene ontology |
Molecular function |
• substrate-specific transmembrane transporter activity
• transmembrane transporter activity
• transporter activity
• fructose binding
• fructose transmembrane transporter activity
• glucose transmembrane transporter activity
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Cellular component |
• integral component of membrane
• membrane
• plasma membrane
• integral component of plasma membrane
• apical plasma membrane
• sarcolemma
• extracellular exosome
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Biological process |
• hexose transport
• carbohydrate metabolic process
• cellular response to fructose stimulus
• transport
• fructose transport
• glucose transport
• carbohydrate transport
• fructose import across plasma membrane
• response to fructose
• transmembrane transport
• glucose transmembrane transport
• regulation of systemic arterial blood pressure mediated by a chemical signal
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Sources:Amigo / QuickGO |
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Orthologs |
Species |
Human |
Mouse |
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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NM_001135585
NM_003039
NM_001328619
NM_001328620
NM_001328621
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RefSeq (protein) |
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NP_001129057.1
NP_003030.1
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Location (UCSC) |
Chr 1: 9.04 – 9.09 Mb |
Chr 4: 150.12 – 150.14 Mb |
PubMed search |
[1] |
[2] |
Wikidata |
View/Edit Human |
View/Edit Mouse |
GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine.[3] GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in skeletal muscle,[4] testis, kidney, fat tissue (adipocytes), and brain.[5]
Fructose malabsorption or Dietary Fructose Intolerance is a dietary disability of the small intestine, where the amount of fructose carrier in enterocytes is deficient.[6]
In humans the GLUT5 protein is encoded by the SLC2A5 gene.[7]
Contents
- 1 Regulation
- 2 Interactive pathway map
- 3 References
- 4 External links
Regulation
Fructose uptake rate by GLUT5 is significantly affected by diabetes mellitus, hypertension, obesity, fructose malabsorption, and inflammation. However, age-related changes in fructose intake capability are not explained by the rate of expression of GLUT5.[8][9][10] The absorption of fructose in the simultaneous presence of glucose is improved, while sorbitol is inhibitory.[11]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
[[File:
|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]
File:WP534.png
Glycolysis and Gluconeogenesis edit
- ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".
References
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ Uldry M, Thorens B (February 2004). "The SLC2 family of facilitated hexose and polyol transporters". Pflügers Archiv : European Journal of Physiology. 447 (5): 480–9. doi:10.1007/s00424-003-1085-0. PMID 12750891.
- ^ Hundal HS, Darakhshan F, Kristiansen S, Blakemore SJ, Richter EA (1998). "GLUT5 expression and fructose transport in human skeletal muscle". Advances in Experimental Medicine and Biology. 441: 35–45. doi:10.1007/978-1-4899-1928-1_4. PMID 9781312.
- ^ Douard V, Ferraris RP (August 2008). "Regulation of the fructose transporter GLUT5 in health and disease". American Journal of Physiology. Endocrinology and Metabolism. 295 (2): E227–37. doi:10.1152/ajpendo.90245.2008. PMC 2652499. PMID 18398011.
- ^ Barone S, Fussell SL, Singh AK, Lucas F, Xu J, Kim C, Wu X, Yu Y, Amlal H, Seidler U, Zuo J, Soleimani M (February 2009). "Slc2a5 (Glut5) Is Essential for the Absorption of Fructose in the Intestine and Generation of Fructose-induced Hypertension". The Journal of Biological Chemistry. 284 (8): 5056–66. doi:10.1074/jbc.M808128200. PMC 2643499. PMID 19091748.
- ^ White PS, Jensen SJ, Rajalingam V, Stairs D, Sulman EP, Maris JM, Biegel JA, Wooster R, Brodeur GM (1998). "Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2". Cytogenetics and Cell Genetics. 81 (1): 60–4. doi:10.1159/000014989. PMID 9691177.
- ^ Douard V, Ferraris RP (August 2008). "Regulation of the fructose transporter GLUT5 in health and disease". Am. J. Physiol. Endocrinol. Metab. 295 (2): E227–37. doi:10.1152/ajpendo.90245.2008. PMC 2652499. PMID 18398011.
- ^ Litherland GJ, Hajduch E, Gould GW, Hundal HS (June 2004). "Fructose transport and metabolism in adipose tissue of Zucker rats: diminished GLUT5 activity during obesity and insulin resistance" (PDF). Mol. Cell. Biochem. 261 (1-2): 23–33. doi:10.1023/b:mcbi.0000028734.77867.d2. PMID 15362482.
- ^ Drozdowski LA, Woudstra TD, Wild GE, Clandinin MT, Thomson AB (October 2004). "Age-associated changes in intestinal fructose uptake are not explained by alterations in the abundance of GLUT5 or GLUT2". J. Nutr. Biochem. 15 (10): 630–7. doi:10.1016/j.jnutbio.2004.06.003. PMID 15542355.
- ^ Heinrich Kasper: Ernährungsmedizin und Diätetik. 11. Auflage, Elsevier, Urban&Fischer-Verlag, 2009, ISBN 9783437420122, S. 208
External links
- GLUT5 Protein at the US National Library of Medicine Medical Subject Headings (MeSH)
Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
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Ion pumps
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Symporter, Cotransporter |
- Na+/K+,Cl−
- Na+/Pi3
- Na+/Cl−
- Na+/glucose
- Na+/I−
- Cl−/K+
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Antiporter (exchanger) |
- Na+/H+
- Na+/Ca2+
- Na+/(Ca2+-K+) - Cl−/HCO−
3 (Band 3)
- Cl−-formate
- Cl−-oxalate
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see also solute carrier disorders
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English Journal
- Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3.
- Vogel GF1, Klee KM2, Janecke AR3, Müller T3, Hess MW4, Huber LA5.
- The Journal of cell biology.J Cell Biol.2015 Nov 9;211(3):587-604. doi: 10.1083/jcb.201506112.
- Mutations in the motor protein Myosin Vb (Myo5B) or the soluble NSF attachment protein receptor Syntaxin 3 (Stx3) disturb epithelial polarity and cause microvillus inclusion disease (MVID), a lethal hereditary enteropathy affecting neonates. To understand the molecular mechanism of Myo5B and Stx3 in
- PMID 26553929
- Effect of dietary fructose on portal and systemic serum fructose levels in rats and in KHK-/- and GLUT5-/- mice.
- Patel C1, Sugimoto K2, Douard V1, Shah A1, Inui H3, Yamanouchi T4, Ferraris RP5.
- American journal of physiology. Gastrointestinal and liver physiology.Am J Physiol Gastrointest Liver Physiol.2015 Nov 1;309(9):G779-90. doi: 10.1152/ajpgi.00188.2015. Epub 2015 Aug 27.
- Elevated blood fructose concentrations constitute the basis for organ dysfunction in fructose-induced metabolic syndrome. We hypothesized that diet-induced changes in blood fructose concentrations are regulated by ketohexokinase (KHK) and the fructose transporter GLUT5. Portal and systemic fructose
- PMID 26316589
- Structure and mechanism of the mammalian fructose transporter GLUT5.
- Nomura N1,2,3, Verdon G4,5,6, Kang HJ4,5,6, Shimamura T1,2,3, Nomura Y1,2,3, Sonoda Y4, Hussien SA7, Qureshi AA7, Coincon M7, Sato Y1,3, Abe H1, Nakada-Nakura Y1,3, Hino T1,2, Arakawa T1,2, Kusano-Arai O8, Iwanari H8, Murata T1,2,3,9, Kobayashi T1,2,3, Hamakubo T8, Kasahara M10, Iwata S1,2,3,4,5,6,9, Drew D4,7.
- Nature.Nature.2015 Oct 15;526(7573):397-401. doi: 10.1038/nature14909. Epub 2015 Sep 30.
- The altered activity of the fructose transporter GLUT5, an isoform of the facilitated-diffusion glucose transporter family, has been linked to disorders such as type 2 diabetes and obesity. GLUT5 is also overexpressed in certain tumour cells, and inhibitors are potential drugs for these conditions.
- PMID 26416735
Japanese Journal
- Induction by Fructose Force-Feeding of Histone H3 and H4 Acetylation at Their Lysine Residues around the <i>Slc2a5</i> Gene and Its Expression in Mice
- Bioscience, Biotechnology, and Biochemistry 77(11), 2188-2191, 2013
- NAID 130003381916
- Gene Expression in Early Expanded Parthenogenetic and In Vitro Fertilized Bovine Blastocysts
- The Journal of reproduction and development 55(6), 607-614, 2009-12-01
- NAID 10026322472
Related Links
- Complete information for SLC2A5 gene (protein-coding), solute carrier family 2 ( facilitated glucose/fructose transporter), member 5.