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1. 遺伝子治療、ゲノム編集、遺伝子発現抑制の概要overview of gene therapy gene editing and gene silencing [show details]
… Insertion of genes that inhibit immune or inflammatory responses (eg, genes from the adenoviral early region 3 [E3] that is responsible for downregulating host responses) . Deletion of viral genes that may …
2. 原発性免疫不全症に対する遺伝子治療gene therapy for primary immunodeficiency [show details]
…of immunodeficiencies are discussed separately. Gene therapy has the potential to cure genetically based diseases. In gene addition therapy, the gene copy must be introduced into a sufficient number of …
3. 遺伝学およびゲノミクスのためのツール：遺伝子発現プロファイリングtools for genetics and genomics gene expression profiling [show details]
… of the expression of thousands of genes simultaneously. In general, the greater the amount of mRNA from a particular gene (ie, the higher the expression of that gene), the more fluorescently-labeled material …
4. 肥大型心筋症：遺伝子変異および臨床遺伝子検査hypertrophic cardiomyopathy gene mutations and clinical genetic testing [show details]
… 2019, up to 11 causative genes with over 1500 mutations in genes encoding the thick or thin myofilament proteins of the sarcomere have been reported . In an analysis of 33 genes frequently included in HCM …
5. Gene test interpretation: CFTRgene test interpretation cftr [show details]
…results of the newborn screen are negative or equivocal. CFTR gene sequencing may identify pathogenic variants in this setting. CFTR gene testing may be performed in individuals with a chronic condition …