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the 19th letter of the Roman alphabet (同)s

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sulfurの化学記号 / {略}South[ern]

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/22 14:54:03」(JST)

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S-Adenosyl-L-homocysteine (SAH) is an amino acid derivative used in several metabolic pathways in most organisms. It is an intermediate in the synthesis of cysteine and adenosine.

SAH is formed by the demethylation of S-adenosyl-L-methionine (SAM), which can be inhibited by 3-Deazaneplanocin_A.

External links

BioCYC E.Coli K-12 Compound: S-adenosyl-L-homocysteine

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1. アデノシンデアミナーゼ欠損症：病因、臨床症状、および診断 adenosine deaminase deficiency pathogenesis clinical manifestations and diagnosis
2. アデノシンデアミナーゼ欠損症：治療 adenosine deaminase deficiency treatment

English Journal

Reduced adenosine release from the aged mammalian heart.

Fenton RA, Dobson JG Jr.SourceDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA. richard.fenton@umassmed.edu
Journal of cellular physiology.J Cell Physiol.2012 Nov;227(11):3709-14. doi: 10.1002/jcp.24079.
Adenosine (ADO) released in the heart results in enhanced coronary blood flow and reduced catecholamine release and myocardial responsiveness to adrenergic stimulation (anti-adrenergic action). ADO release from the adrenergic-stimulated aged heart is less than that from the young adult heart. Becaus
PMID 22378276

Genetic polymorphisms modulate the folate metabolism of Brazilian individuals with Down syndrome.

Biselli JM, Zampieri BL, Goloni-Bertollo EM, Haddad R, Fonseca MF, Eberlin MN, Vannucchi H, Carvalho VM, Pavarino EC.SourceDepartamento de Biologia Molecular, Faculdade de Medicina de São José do Rio Preto (FAMERP), Unidade de Pesquisa em Genética e Biologia Molecular (UPGEM), Av. Brigadeiro Faria Lima, n.o 5416-Bloco U-6, São José do Rio Preto, SP, CEP: 15.090-000, Brazil.
Molecular biology reports.Mol Biol Rep.2012 Oct;39(10):9277-84. Epub 2012 Aug 19.
Individuals with Down syndrome (DS) carry three copies of the Cystathionine β-synthase (CβS) gene. The increase in the dosage of this gene results in an altered profile of metabolites involved in the folate pathway, including reduced homocysteine (Hcy), methionine, S-adenosylhomocysteine (SAH) and
PMID 22903356

Japanese Journal

Factors Contributing to the Resistivity of a Higher Casein Diet against Choline Deficiency-Induced Hyperhomocysteinemia in Rats

LIU Yi-qun,LIU Ying,MORITA Tatsuya [他],MORI Makoto,SUGIYAMA Kimio
Journal of Nutritional Science and Vitaminology 58(2), 78-87, 2012
… Choline deprivation-induced increases in hepatic S-adenosylhomocysteine and homocysteine concentrations were significantly suppressed by supplementation with glycine+serine and further suppressed by BCAA+AAA. …
NAID 130002103035

Determination of S-Adenosylmethionine and S-Adenosylhomocysteine by LC-MS/MS and evaluation of their stability in mice tissues

KRIJT Jakub,DUTA Alena,KOZICH Viktor
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 877(22), 2061-2066, 2009-07-15
NAID 10028020293

Hepatic Cystathionine β-Synthase Activity Does Not Increase in Response to Methionine Supplementation in Rats Fed a Low Casein Diet : Association with Plasma Homocysteine Concentrations

Ohuchi Seiya,Morita Tatsuya,Mori Makoto [他],SUGIYAMA Kimio
Journal of nutritional science and vitaminology 55(2), 178-185, 2009-04-01
… Increased concentrations of hepatic S-adenosylhomocysteine and homocysteine due to methionine supplementation were also significantly suppressed by glycine+serine. … In contrast, the activity of hepatic betaine-homocysteine S-methyltransferase (BHMT) significantly increased with increase in both dietary casein level and dietary methionine level. …
NAID 10025970986

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関連記事	「adenosylhomocysteine」「S」

「adenosylhomocysteine」

S-Adenosyl-L-homocysteine
Names
	IUPAC name S-(5'-Deoxyadenos-5'-yl)-L-homocysteine
	Other names AdoHcy, 2-S-adenosyl-L-homocysteine,; 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine S-adenosylhomocysteine, SAH
Identifiers
CAS Registry Number	979-92-0
ChEBI	CHEBI:16680
ChEMBL	ChEMBL418052
ChemSpider	388301
	InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 ; Key: ZJUKTBDSGOFHSH-WFMPWKQPSA-N ; InChI=1/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1; Key: ZJUKTBDSGOFHSH-WFMPWKQPBX ;
IUPHAR/BPS	5265
Jmol-3D images	Image
KEGG	C00021
MeSH	S-Adenosylhomocysteine
PubChem	439155
	SMILES O=C(O)[C@@H](N)CCSC[C@H]3O[C@@H](n2cnc1c(ncnc12)N)[C@H](O)[C@@H]3O ;
Properties
Chemical formula	C14H20N6O5S
Molar mass	384.412
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references