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cardiac ryanodine receptorryanodine receptorryanodine receptor 2ryanodine receptor calcium release channelRyR1RyR3type 2 ryanodine receptor

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/09 18:34:42」(JST)

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  • Essential Role of Calmodulin in RyR Inhibition by Dantrolene.
  • Oo YW1, Gomez-Hurtado N1, Walweel K1, van Helden DF1, Imtiaz MS1, Knollmann BC1, Laver DR2.
  • Molecular pharmacology.Mol Pharmacol.2015 Jul;88(1):57-63. doi: 10.1124/mol.115.097691. Epub 2015 Apr 28.
  • Dantrolene is the first line therapy of malignant hyperthermia. Animal studies suggest that dantrolene also protects against heart failure and arrhythmias caused by spontaneous Ca(2+) release. Although dantrolene inhibits Ca(2+) release from the sarcoplasmic reticulum of skeletal and cardiac muscle
  • PMID 25920678
  • PMID 25736969
  • The ryanodine receptor provides high throughput Ca2+-release but is precisely regulated by networks of associated proteins: a focus on proteins relevant to phosphorylation.
  • O'Brien F1, Venturi E1, Sitsapesan R1.
  • Biochemical Society transactions.Biochem Soc Trans.2015 Jun 1;43(3):426-33. doi: 10.1042/BST20140297.
  • Once opened, ryanodine receptors (RyR) are efficient pathways for the release of Ca2+ from the endoplasmic/sarcoplasmic reticulum (ER/SR). The precise nature of the Ca2+-release event, however, requires fine-tuning for the specific process and type of cell involved. For example, the spatial organiz
  • PMID 26009186


  • 心不全・致死的不整脈における細胞内カルシウム放出異常
  • 矢野 雅文
  • 山口医学 63(1), 11-16, 2014-02-01
  • … し病態の悪化に深く関与することを示した.一方,このようなRyR機能異常を正常化することにより心不全の発現を抑制できる可能性が実験的に示されるようになり,RyRは新たな心不全・致死的不整脈の治療ターゲットとしても期待しうる.Two domains within the ryanodine receptor(RyR2)of sarcoplasmic reticulum(SR){N-terminal(0-600)and central(2000-2500)domains:N-C domains},harboring many mutations in CPVT, was found to interact with each other as a regulatory switch for channel …
  • NAID 120005435141
  • Increased Phosphorylation of Ca²⁺ Handling Proteins as a Proarrhythmic Mechanism in Myocarditis
  • Park Hyelim,Park Hyewon,Lee Dajeong [他],Oh Sujung,Lim Jisoo,Hwang Hye jin,Park Sungha,Pak Hui-Nam,Lee Moon-Hyoung,Joung Boyoung
  • Circulation Journal 78(9), 2292-2301, 2014
  • … CaMKII autophosphorylation at Thr287 (201%), and RyR2 phosphorylation at Ser2808 (protein kinase A/CaMKII site, 126%) and Ser2814 (CaMKII site, 21%) were increased in rats with myocarditis and reversed by steroid.Conclusions:The myocarditis group had an increased incidence of arrhythmia caused by increased phosphorylation of Ca2+handling proteins. …
  • NAID 130004677617
  • 心不全・致死的不整脈における細胞内カルシウム放出異常
  • 矢野 雅文
  • 山口医学 63(1), 11-16, 2014
  • 心筋細胞膜の脱分極が生じるごとにL型 Ca2+チャネル(LTCC)から少量のCa2+が流入し,その流入Ca2+がトリガーとなり筋小胞体(SR)膜上にあるCa2+放出チャネルのリアノジン受容体(RyR)からの大量のCa2+放出を引き起こす.細胞内の増加したCa2+は,収縮蛋白を活性化した後,SRのCa2+-ATPaseによりSR内に再び取り込まれるとともに,一部はNa+/Ca2+交換機構や細胞膜Ca …
  • NAID 130004476032


キーワード 心疾患、Ca2+放出チャンネル、ペースメーカー、リアノジン 歴史とあらまし 1990年にウサギ心筋小胞体からカルシウム放出チャンネル(リアノジン受容体)としてcDNAがクローニングされた(Ref. 1)。ヒトRYR2は、N末の ...
Complete information for RYR2 gene (protein-coding), ryanodine receptor 2 (cardiac), including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... Function for RYR2 ...


RyR2 Ca2+ leak, mechanisms of RyR2 RyR2The leaky RyR2 hypothesis: phosphorylation RyR2 and Calcium RYR2 mutations, bradycardia, and follow upRyanodine Receptor 2 (RYR2) (pSer2814) pAb

リンク元リアノジン受容体2型」「RyR1」「RyR3」「cardiac ryanodine receptor」「ryanodine receptor calcium release channel



type 2 ryanodine receptorryanodine receptor 2cardiac ryanodine receptorRyR2



ryanodine receptorryanodine receptor 1ryanodine receptor calcium release channelRyR2RyR3skeletal muscle ryanodine receptortype 1 ryanodine receptor



ryanodine receptorryanodine receptor 3ryanodine receptor calcium release channelRyR1RyR2type 3 ryanodine receptor

cardiac ryanodine receptor」


ryanodine receptor 2RyR2type 2 ryanodine receptor

ryanodine receptor calcium release channel」


ryanodine receptorRyR1RyR2RyR3



ryanodine receptor

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