WordNet

inflammation of the thyroid gland

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/18 21:35:31」(JST)

wiki en

Riedel's thyroiditis, also called Riedel's struma is a chronic form of thyroiditis.

It is believed to be a form of autoimmune thyroiditis.^[1]

Pathophysiology[edit]

Riedel's thyroiditis is characterized by a replacement of the normal thyroid parenchyma by a dense fibrosis that invades adjacent structures of the neck and extends beyond the thyroid capsule.^[2] This makes the thyroid gland stone-hard and fixed to adjacent structures. The inflammatory process infiltrates muscles and causes symptoms of tracheal compression. Surgical treatment is required to relieve tracheal or esophageal obstruction.

It is now believed that Riedel's thyroiditis is one manifestation of a systemic disease that can affect many organ systems called IgG4-related disease. ^[3]

Many newly named diseases that begin with the IgG4 immunoglobulin are just new names for single symptoms of the more readily understood name Systemic Antiphospholipid Syndrome, which from the simple word Systemic means that it involves all tissue and organs. We would be better off looking up Systemic Antiphospholipid Syndrome than the individual symptoms related to the Antiphospholipid Antibody (the Immunoglobulin IgG4)

Prevalence[edit]

Riedel's thyroiditis is classified as rare. Most patients remain euthyroid, but approximately 30% of patients become hypothyroid and very few patients are hyperthyroid. It is most seen in women.^[4]

Treatment[edit]

Therapy usually consists of prednisone(?), nonetheless some cases may require surgery. Tamoxifen has been proposed as part of a treatment plan.^[5]

Treatment is directed to surgical relief of compressive symptoms. Tamoxifen may also be beneficial. -Harrison's principle of internal medicine, 17th

The type Surgery which is indicated here is isthmectomy.

Eponym[edit]

It is named for Bernhard Riedel. He first recognized the disease In 1883 and published its description in 1896.^[6]^[7]

References[edit]

^ "autoimmune thyroiditis" at Dorland's Medical Dictionary
^ Cho MH, Kim CS, Park JS, et al. (August 2007). "Riedel's thyroiditis in a patient with recurrent subacute thyroiditis: a case report and review of the literature" (– ^{Scholar search}). Endocr. J. 54 (4): 559–62. doi:10.1507/endocrj.K06-186. PMID 17603227. ^{[dead link]}
^ Stone JH (February 2012). "IgG4-Related Disease". New England Journal of Medicine 336 (6): 539–51. doi:10.1056/NEJMra1104650. PMID 22316447.
^ eMedicine
^ Dabelic N, Jukic T, Labar Z, Novosel SA, Matesa N, Kusic Z (April 2003). "Riedel's thyroiditis treated with tamoxifen" (PDF). Croat. Med. J. 44 (2): 239–41. PMID 12698518.
^ B. M. C. L. Riedel. Die chronische, zur Bildung eisenharter Tumoren führende Entzündung der Schilddrüse. Verhandlungen der deutschen Gesellschaft für Chirurgie, 1896, 25: 101-105.
^ synd/3242 at Who Named It?

]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 浸潤性甲状腺疾患 infiltrative thyroid disease
2. 甲状腺の概要 overview of thyroiditis
3. 線維性縦隔炎 fibrosing mediastinitis
4. 硬化性腸間膜炎 sclerosing mesenteritis
5. 甲状腺機能低下症の原因となる疾患 disorders that cause hypothyroidism

English Journal

IgG4 Related Disease of the Head and Neck.

Deshpande V1.
Head and neck pathology.Head Neck Pathol.2015 Mar;9(1):24-31. doi: 10.1007/s12105-015-0620-6. Epub 2015 Mar 25.
IgG4 related disease of the head and neck region represents one of the more common manifestations of IgG4 related disease. Involvement of the submandibular and parotid glands, the orbit and thyroid represent some of the more common sites involved by IgG4 related disease. Eosinophilic angiocentric fi
PMID 25804380

Fibrosis of the thyroid gland caused by an IgG4-related sclerosing disease: three years of follow-up.

Oriot P, Amraoui A, Rousseau E, Malvaux P, Dechambre S, Delcourt A.
Acta clinica Belgica.Acta Clin Belg.2014 Dec;69(6):446-50. doi: 10.1179/2295333714Y.0000000046. Epub 2014 Sep 16.
Immunoglobulin G4-related sclerosing disease (IgG4-RSD) represents a recently identified inflammatory disorder in which infiltration of IgG4 plasma cells causes fibrosis in organs. While IgG4-RSD is well documented in the pancreas and other organs, it is poorly characterized in the thyroid gland. We
PMID 25224542

¹⁸F-FDG PET-CT usefulness in extra-pancreatic involvement in IgG4 related diseases.

Cárdenas-Perilla R1, Monturiol-Duran J2, Simó-Perdigó M2, Barios-Profitós M2, Castell-Conesa J2.
Revista española de medicina nuclear e imagen molecular.Rev Esp Med Nucl Imagen Mol.2014 Nov-Dec;33(6):366-9. doi: 10.1016/j.remn.2014.01.005. Epub 2014 Mar 12.
IgG4-related diseases are a group of recently identified entities that include disorders that were previously known by other names, such as Mikulicz disease, Küttner's tumor, Riedel thyroiditis, among others, as well as some new ones described in the last years. These pathologies are a challenge fo
PMID 24630373

Japanese Journal

悪性リンパ腫やRiedel甲状腺炎と鑑別を要した橋本病線維亜型の1例

尾身葉子,山本智子,澤田達男,西川俊郎,岡本高宏,小林槇雄
東京女子医科大学雑誌 81(E1), E61-E64, 2011-03-31
… 今回我々は、臨床的に限局性病変を示したため、悪性リンパ腫(ML)との鑑別を要し、組織学的にはRiedel甲状腺炎(RT)との鑑別を要したHTFVの1例を経験したので、文献的考察を加え、報告する。 …
NAID 110008439101