RBL1

• retinoblastoma-like protein p107

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/04 15:57:21」(JST)

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Retinoblastoma-like 1 (p107)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1H28
Identifiers
Symbols	RBL1; CP107; PRB1; p107
External IDs	OMIM: 116957 MGI: 103300 HomoloGene: 2172 GeneCards: RBL1 Gene
Gene Ontology Molecular function • protein binding • transcription factor binding Cellular component • nucleoplasm • transcription factor complex Biological process • G1 phase of mitotic cell cycle • negative regulation of transcription from RNA polymerase II promoter • mitotic cell cycle • transcription, DNA-dependent • transcription initiation from RNA polymerase II promoter • transforming growth factor beta receptor signaling pathway • gene expression • chromatin modification • virus-host interaction • regulation of lipid kinase activity • positive regulation of transcription from RNA polymerase II promoter • regulation of cell cycle Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5933	19650
Ensembl	ENSG00000080839	ENSMUSG00000027641
UniProt	P28749	Q64701
RefSeq (mRNA)	NM_002895	NM_001139516
RefSeq (protein)	NP_002886	NP_001132988
Location (UCSC)	Chr 20: 35.62 – 35.72 Mb	Chr 2: 157.15 – 157.2 Mb
PubMed search	[1]	[2]

Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene.

Function

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 Large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

Retinoblastoma-like protein 1 has been shown to interact with HDAC1, RBBP8, E2F1, Cyclin-dependent kinase 2, BEGAIN, BRF1, BRCA1, Cyclin A2, Prohibitin, MYBL2 and Mothers against decapentaplegic homolog 3.

See also

• Pocket protein family

References

Further reading

• Faha B, Ewen ME, Tsai LH, et al. (1992). "Interaction between human cyclin A and adenovirus E1A-associated p107 protein.". Science 255 (5040): 87–90. doi:10.1126/science.1532458. PMID 1532458. 
• Ewen ME, Xing YG, Lawrence JB, Livingston DM (1991). "Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein.". Cell 66 (6): 1155–64. doi:10.1016/0092-8674(91)90038-Z. PMID 1833063. 
• Datta PK, Raychaudhuri P, Bagchi S (1995). "Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription.". Mol. Cell. Biol. 15 (10): 5444–52. PMC 230794. PMID 7565695. 
• Zhu L, Zhu L, Xie E, Chang LS (1995). "Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins.". Mol. Cell. Biol. 15 (7): 3552–62. PMC 230592. PMID 7791762. 
• Sardet C, Vidal M, Cobrinik D, et al. (1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2403–7. doi:10.1073/pnas.92.6.2403. PMC 42492. PMID 7892279. 
• Kim YW, Otterson GA, Kratzke RA, et al. (1994). "Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein.". Mol. Cell. Biol. 14 (11): 7256–64. PMC 359260. PMID 7935440. 
• Ginsberg D, Vairo G, Chittenden T, et al. (1994). "E2F-4, a new member of the E2F transcription factor family, interacts with p107.". Genes Dev. 8 (22): 2665–79. doi:10.1101/gad.8.22.2665. PMID 7958924. 
• Beijersbergen RL, Kerkhoven RM, Zhu L, et al. (1994). "E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.". Genes Dev. 8 (22): 2680–90. doi:10.1101/gad.8.22.2680. PMID 7958925. 
• Beijersbergen RL, Hijmans EM, Zhu L, Bernards R (1994). "Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation.". EMBO J. 13 (17): 4080–6. PMC 395329. PMID 8076603. 
• Dyson N, Dembski M, Fattaey A, et al. (1993). "Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1.". J. Virol. 67 (12): 7641–7. PMC 238233. PMID 8230483. 
• Zhu L, van den Heuvel S, Helin K, et al. (1993). "Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.". Genes Dev. 7 (7A): 1111–25. doi:10.1101/gad.7.7a.1111. PMID 8319904. 
• Ikeda MA, Jakoi L, Nevins JR (1996). "A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation.". Proc. Natl. Acad. Sci. U.S.A. 93 (8): 3215–20. doi:10.1073/pnas.93.8.3215. PMC 39585. PMID 8622916. 
• Xiao ZX, Ginsberg D, Ewen M, Livingston DM (1996). "Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases.". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4633–7. doi:10.1073/pnas.93.10.4633. PMC 39330. PMID 8643455. 
• Vidal M, Brachmann RK, Fattaey A, et al. (1996). "Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions.". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10315–20. doi:10.1073/pnas.93.19.10315. PMC 38381. PMID 8816797. 
• Shao Z, Siegert JL, Ruppert S, Robbins PD (1997). "Rb interacts with TAF(II)250/TFIID through multiple domains.". Oncogene 15 (4): 385–92. doi:10.1038/sj.onc.1201204. PMID 9242374. 
• Verona R, Moberg K, Estes S, et al. (1997). "E2F activity is regulated by cell cycle-dependent changes in subcellular localization.". Mol. Cell. Biol. 17 (12): 7268–82. PMC 232584. PMID 9372959. 
• Trimarchi JM, Fairchild B, Verona R, et al. (1998). "E2F-6, a member of the E2F family that can behave as a transcriptional repressor.". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 2850–5. doi:10.1073/pnas.95.6.2850. PMC 19658. PMID 9501179. 
• Sterner JM, Dew-Knight S, Musahl C, et al. (1998). "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7.". Mol. Cell. Biol. 18 (5): 2748–57. PMC 110654. PMID 9566894. 
• Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (1998). "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability.". Nat. Genet. 19 (4): 371–4. doi:10.1038/1258. PMID 9697699. 
• Veal E, Eisenstein M, Tseng ZH, Gill G (1998). "A cellular repressor of E1A-stimulated genes that inhibits activation by E2F.". Mol. Cell. Biol. 18 (9): 5032–41. PMC 109088. PMID 9710587. 

External links

• RBL1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

English Journal

• Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas.

• Xie C1, Lu H2, Nomura A3, Hanse EA4, Forster CL5, Parker JB6, Linden MA7, Karasch C8, Hallstrom TC9.
• Molecular cancer.Mol Cancer.2015 Apr 24;14:93. doi: 10.1186/s12943-015-0360-y.
• BACKGROUND: Rb1 is the most frequently mutated gene in the pediatric cancer retinoblastoma, and its loss causes E2F transcription factors to induce proliferation related genes. However, high E2F levels following pRB loss also induce apoptosis-promoting genes as a safeguard mechanism to suppress emer
• PMID 25907958

• Genome-wide haplotype association study identifies BLM as a risk gene for prostate cancer in Chinese population.

• Wang Q1, Lv H, Lv W, Shi M, Zhang M, Luan M, Zhu H, Zhang R, Jiang Y.
• Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.Tumour Biol.2015 Apr;36(4):2703-7. doi: 10.1007/s13277-014-2893-x. Epub 2014 Dec 4.
• Prostate cancer (PC) is a common malignant tumor that occurs in the prostate epithelial cells. It is generally considered to be caused by both genetic and environmental factors. To identify the genetic risk factors of PC in Chinese population, we carried out a genome-wide haplotype-based association
• PMID 25472581

• Rb suppresses human cone-precursor-derived retinoblastoma tumours.

• Xu XL1, Singh HP2, Wang L3, Qi DL2, Poulos BK4, Abramson DH5, Jhanwar SC6, Cobrinik D7.
• Nature.Nature.2014 Oct 16;514(7522):385-8. doi: 10.1038/nature13813. Epub 2014 Sep 24.
• Retinoblastoma is a childhood retinal tumour that initiates in response to biallelic RB1 inactivation and loss of functional retinoblastoma (Rb) protein. Although Rb has diverse tumour-suppressor functions and is inactivated in many cancers, germline RB1 mutations predispose to retinoblastoma far mo
• PMID 25252974

Related Links

• www.rbl1.ph

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• 地デジ室内アンテナ Atredia｜テレビ受信機器｜日本アンテナ

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