Membrane transport protein: ion channels (TC 1A)
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Ca2+: Calcium channel
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Ligand-gated
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Inositol trisphosphate receptor (1, 2, 3) · Ryanodine receptor (1, 2, 3)
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Voltage-gated
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L-type/ Cavα (1.1, 1.2, 1.3, 1.4) · N-type/ Cavα2.2 · P-type/ Cavα(2.1) · Q-type/ Cavα2.1 · R-type/ Cavα2.3 · T-type/ Cavα(3.1, 3.2, 3.3)
α2δ-subunits (1, 2) · β-subunits (β1, β2, β3, β4) · γ-subunits (γ1, γ2, γ3, γ4)
Cation channels of sperm (1, 2, 3, 4) · Two-pore channel (1, 2)
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Na+: Sodium channel
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Constitutively active
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Epithelial sodium channel (α, β, γ, δ)
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Proton-gated
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Amiloride-sensitive cation channel (1, 2, 3, 4)
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Voltage-gated
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Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) · Navβ (1, 2, 3, 4)
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K+: Potassium channel
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Calcium-activated
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BK channel (α1, β1, β2, β3, β4) · SK channel (SK1, SK2, SK3) · IK channel (IK1) · KCa (1.1, 2.1, 2.2, 2.3, 3.1, 4.1, 4.2, 5.1)
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Inward-rectifier
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KATP · Kir (1.1, 2.1, 2.2, 2.3, 2.4, 2.6) · GIRK/Kir (3.1, 3.2, 3.3, 3.4) · Kir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)
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Tandem pore domain
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K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)
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Voltage-gated
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Kvα1-6 (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8) · (2.1, 2.2) · (3.1, 3.2, 3.3, 3.4) · (4.1, 4.2, 4.3) · (5.1) · (6.1, 6.2, 6.3, 6.4)
Kvα7-12 (7.1, 7.2, 7.3, 7.4, 7.5) · (8.1, 8.2) · (9.1, 9.2, 9.3) · (10.1, 10.2) · (11.1/hERG, 11.2, 11.3) · (12.1, 12.2, 12.3)
Kvβ (1, 2, 3) · KCNIP (1, 2, 3, 4) · minK/ISK · minK/ISK-like · MiRP (1, 2, 3) · Shaker gene
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Miscellaneous
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Cl-: Chloride channel
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ANO1 · Bestrophin (1, 2) · CFTR · CLCA (1, 2, 3, 4) · CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) · CLIC (1, 2, 3, 4, 5, 6, L1) · CLNS (1A, 1B)
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H+: Proton channel
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HVCN1
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M+: CNG cation channel
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α (1, 2, 3, 4) · β (1, 2, 3) · HCN (FC, 1, 2, 3, 4)
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M+: TRP cation channel
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TRPA (1) · TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) · TRPM (1, 2, 3, 4, 5, 6, 7, 8) · TRPML (1, 2, 3) · TRPN · TRPP (1, 2) · TRPV (1, 2, 3, 4, 5, 6)
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H2O (+ solutes): Porin
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Aquaporin (0, 1, 2, 3, 4, 5, 6, 7, 8, 9) · Voltage-dependent anion channel (1, 2, 3) · General bacterial porin family
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Cytoplasm: Gap junction
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Connexin: A (GJA1, GJA3, GJA4, GJA5, GJA8, GJA9, GJA10) · B (GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7) · C (GJC1, GJC2, GJC3) · D (GJD2, GJD3, GJD4))
Innexin
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By gating mechanism
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Ion channel class
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Ligand-gated · Light-gated · Voltage-gated · Stretch-activated
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see also disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), other
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