同: PUUV

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a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
(virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus

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ビールス,ろ過性病原体

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/06/03 03:23:48」(JST)

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Puumala virus (PUUV) is a species of hantavirus. Humans infected with the virus may develop a haemorrhagic fever with renal syndrome (HFRS) known as nephropathia epidemica. Puumala virus HFRS is lethal in less than 0.5% of the cases.^[1]

Puumala virus is named after a municipality in Finland. The virus is found predominantly in Scandinavia and Finland, although it has also been reported elsewhere in Northern Europe, Poland and Russia. Because the bank vole (Myodes glareolus) acts as a reservoir for the virus, nephropathia epidemica cases track with the vole population in a three- to four-year cycle. Humans are infected through inhalation of dust from vole droppings.^[2]

It has been theorized that Puumala virus, unlike other members of the genus Hantavirus, may also have lethal effects on its rodent host.^[3]

In August 2014 was announced the death of an Israeli researcher studying the behavior of the bank vole in Finland. She had been affected by the Puumala virus which caused a complete breakdown of her immune system.^[4]

Puumala virus was discovered and named in 1980 by researchers in Finland.^[5]

References

^ Discertation for doctoral exam; Distribution of Puumalavirus in Sweden, by C. Ahlm, second paragraph; latest access 2012-06-04
^ Rose A, Vapalahti O, Lyytikäinen O, Nuorti P (January 2003). "Patterns of Puumala virus infection in Finland". Euro Surveill. 8 (1): 9–13. PMID 12631978.
^ Kallio ER, Voutilainen L, Vapalahti O, Vaheri A, Henttonen H, Koskela E, Mappes T (August 2007). "Endemic hantavirus infection impairs the winter survival of its rodent host". Ecology. 88 (8): 1911–6. doi:10.1890/06-1620.1. PMID 17824420.
^ http://www.ynet.co.il/articles/0,7340,L-4555889,00.html
^ Brummer-Korvenkontio, M.; Vaheri, A.; Hovi, T.; Von Bonsdorff, C. H.; Vuorimies, J.; Manni, T.; Penttinen, K.; Oker-Blom, N.; Lähdevirta, J. (1980). "Nephropathia epidemica: detection of antigen in bank voles and serologic diagnosis of human infection". The Journal of Infectious Diseases. 141 (2): 131–134. doi:10.1093/infdis/141.2.131. PMID 6102587.

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1. ハンタウイルス感染の疫学および診断 epidemiology and diagnosis of hantavirus infections
2. ハンタウイルス心肺症候群 hantavirus cardiopulmonary syndrome
3. ハンタウイルス感染による腎疾患（腎症候性出血熱） renal involvement with hantavirus infection hemorrhagic fever with renal syndrome
4. ハンタウイルス感染の病因 pathogenesis of hantavirus infections
5. 東アジアへの旅行によって感染する可能性のある疾患 diseases potentially acquired by travel to east asia

English Journal

Relating land cover and spatial distribution of nephropathia epidemica and Lyme borreliosis in Belgium.

Barrios JM, Verstraeten WW, Maes P, Aerts JM, Farifteh J, Coppin P.Sourcea Biosystems Department, M3-BIORES , Katholieke Universiteit Leuven, Willem de Croylaan 34 , B3001 Heverlee , Belgium.
International journal of environmental health research.Int J Environ Health Res.2013 Apr;23(2):132-54. doi: 10.1080/09603123.2012.708918. Epub 2012 Aug 15.
Lyme borreliosis (LB) and nephropathia epidemica (NE) are zoonoses resulting from two different transmission mechanisms and the action of two different pathogens: the bacterium Borrelia burgdorferi and the Puumala virus, respectively. The landscape configuration is known to influence the spatial spr
PMID 22894742

Puumala virus infections associated with cardiovascular causes of death.

Connolly-Andersen AM, Ahlm K, Ahlm C, Klingström J.AbstractWe studied the causes of death of patients in Sweden with diagnoses of hemorrhagic fever with renal syndrome (HFRS) during 1997-2009. Cardiovascular disorders were a common cause of death during acute-phase HFRS and were the cause of death for >50% of those who died during the first year after HFRS.
Emerging infectious diseases.Emerg Infect Dis.2013 Jan;19(1):126-8. doi: 10.3201/eid1901.111587.
We studied the causes of death of patients in Sweden with diagnoses of hemorrhagic fever with renal syndrome (HFRS) during 1997-2009. Cardiovascular disorders were a common cause of death during acute-phase HFRS and were the cause of death for >50% of those who died during the first year after HF
PMID 23260342

Construction and nonclinical testing of a Puumala virus synthetic M gene-based DNA vaccine.

Brocato RL, Josleyn MJ, Wahl-Jensen V, Schmaljohn CS, Hooper JW.SourceVirology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Clinical and vaccine immunology : CVI.Clin Vaccine Immunol.2012 Dec 12. [Epub ahead of print]
Puumala virus (PUUV) is a causative agent of hemorrhagic fever with renal syndrome (HFRS). Although PUUV-associated HFRS does not result in high case-fatality rates, the social and economic impact is considerable. There is no licensed vaccine or specific therapeutic to prevent or treat HFRS. Here, w
PMID 23239797

Japanese Journal

Role of nucleocapsid protein of hantaviruses in intracellular traffic of viral glycoproteins

Virus
NAID 120005372351

Puumala virus infection in Syrian hamsters (Mesocricetus auratus) resembling hantavirus infection in natural rodent hosts

Virus
NAID 120003464630

Epidemiological Study of Hantavirus Infection in the Samara Region of European Russia

Journal of Veterinary Medical Science 71(12), 1569-1578, 2009
NAID 130000149982

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