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1. 歯性感染症の疫学、病因、および臨床症状 epidemiology pathogenesis and clinical manifestations of odontogenic infections
2. ノーマ（壊疽性口内炎） noma cancrum oris
3. 小児における歯周病関連の全身疾患 systemic conditions associated with periodontal disease in children
4. 口臭 bad breath
5. 口蓋垂炎の臨床的特徴および治療 clinical features and treatment of uvulitis

English Journal

Periodontitis and Porphyromonas gingivalis in Patients with Rheumatoid Arthritis.

Mikuls TR, Payne JB, Yu F, Thiele GM, Reynolds RJ, Cannon GW, Markt J, McGowan D, Kerr GS, Redman RS, Reimold A, Griffiths G, Beatty M, Gonzalez S, Bergman DA, Hamilton BC, Erickson AR, Sokolove J, Robinson W, Walker C, Chandad F, O'Dell JR.Author information Omaha Veterans Affairs Medical Center (VAMC) and Nebraska Arthritis Outcomes Research Center, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA.AbstractPurpose: To examine the degree to which shared risk factors explain the relationship of periodontitis (PD) with rheumatoid arthritis (RA) and to examine associations of PD and Porphyomonas gingivalis (Pg) with disease features. Methods: RA cases (N=287) and controls (N=330) underwent a standardized periodontal examination. HLA-DRB1 status was imputed using SNPs from the extended MHC. Circulating anti-Pg antibody was measured using ELISA and subgingival plaque was assessed for the presence of Pg using PCR. Associations of PD with RA were examined using multivariable regression. Results: PD was more common in RA (35%, p = 0.022) and aCCP positive RA (n=240; 37%; p = 0.006) vs. controls (26%). There were no RA-control differences in anti-Pg or the frequency of Pg positivity by PCR. Anti-Pg antibody showed weak but statistically significant associations with both anti-CCP (r=0.14, p=0.022) and RF (r=0.19, p=0.001). PD was associated with increased swollen joint counts (p=0.004), DAS-28-CRP (p=0.045), total Sharp scores (p=0.015), aCCP (p=0.011), and RF (p<0.001). Select anti-citrullinated peptide antibody (ACPA; including antibody to citrullinated filaggrin) were higher in patients with subgingival Pg and higher anti-Pg antibody levels irrespective of smoking. Associations of PD with established seropositive RA were independent of all covariates examined including evidence of Pg infection. Conclusions: Both PD and Pg appear to shape RA-related autoreactivity in RA. In addition, PD demonstrates an independent relationship with established seropositive RA. © 2013 American College of Rheumatology.
Arthritis and rheumatism.Arthritis Rheum.2014 Jan 8. doi: 10.1002/art.38348. [Epub ahead of print]
Purpose: To examine the degree to which shared risk factors explain the relationship of periodontitis (PD) with rheumatoid arthritis (RA) and to examine associations of PD and Porphyomonas gingivalis (Pg) with disease features. Methods: RA cases (N=287) and controls (N=330) underwent a standardized
PMID 24403127

Antibiotic resistance in human peri-implantitis microbiota.

Rams TE, Degener JE, van Winkelhoff AJ.Author information Department of Periodontology and Oral Implantology, and Oral Microbiology Testing Service Laboratory, Temple University School of Dentistry, Philadelphia, PA, USA; Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA, USA; Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.AbstractOBJECTIVES: Because antimicrobial therapy is often employed in the treatment of infectious dental implant complications, this study determined the occurrence of in vitro antibiotic resistance among putative peri-implantitis bacterial pathogens.
Clinical oral implants research.Clin Oral Implants Res.2014 Jan;25(1):82-90. doi: 10.1111/clr.12160. Epub 2013 Apr 2.
OBJECTIVES: Because antimicrobial therapy is often employed in the treatment of infectious dental implant complications, this study determined the occurrence of in vitro antibiotic resistance among putative peri-implantitis bacterial pathogens.METHODS: Submucosal biofilm specimens were cultured from
PMID 23551701

Antibiotic resistance in human chronic periodontitis microbiota.

Rams TE, Degener JE, van Winkelhoff AJ.Author information Department of Periodontology and Oral Implantology, and Oral Microbiology Testing Service Laboratory, Temple University School of Dentistry, Philadelphia, PA.AbstractBackground: Patients with chronic periodontitis (CP) may yield multiple species of putative periodontal bacterial pathogens that vary in their antibiotic drug susceptibility. This study determines the occurrence of in vitro antibiotic resistance among selected subgingival periodontal pathogens in patients with CP. Methods: Subgingival biofilm specimens from inflamed deep periodontal pockets were removed before treatment from 400 adults with CP in the United States. The samples were cultured, and selected periodontal pathogens were tested in vitro for susceptibility to amoxicillin at 8 mg/L, clindamycin at 4 mg/L, doxycycline at 4 mg/L, and metronidazole at 16 mg/L, with a post hoc combination of data for amoxicillin and metronidazole. Gram-negative enteric rods/pseudomonads were subjected to ciprofloxacin disk-diffusion testing. Results: Overall, 74.2% of the patients with CP revealed subgingival periodontal pathogens resistant to at least one of the test antibiotics. One or more test species, most often Prevotella intermedia/nigrescens, Streptococcus constellatus, or Aggregatibacter actinomycetemcomitans, were resistant in vitro to doxycycline, amoxicillin, metronidazole, or clindamycin, in 55%, 43.3%, 30.3%, and 26.5% of the patients with CP, respectively. Fifteen percent of patients harbored subgingival periodontal pathogens resistant to both amoxicillin and metronidazole, which were mostly either S. constellatus (45 individuals) or ciprofloxacin-susceptible strains of Gram-negative enteric rods/pseudomonads (nine individuals). Conclusions: Patients with CP in the United States frequently yielded subgingival periodontal pathogens resistant in vitro to therapeutic concentrations of antibiotics commonly used in clinical periodontal practice. The wide variability found in periodontal pathogen antibiotic-resistance patterns should concern clinicians empirically selecting antibiotic treatment regimens for patients with CP.
Journal of periodontology.J Periodontol.2014 Jan;85(1):160-9. doi: 10.1902/jop.2013.130142. Epub 2013 May 20.
Background: Patients with chronic periodontitis (CP) may yield multiple species of putative periodontal bacterial pathogens that vary in their antibiotic drug susceptibility. This study determines the occurrence of in vitro antibiotic resistance among selected subgingival periodontal pathogens in pa
PMID 23688097

Japanese Journal

歯周病患者は脳卒中になりやすい？

細見直永,松本昌泰
脳循環代謝（日本脳循環代謝学会機関誌） 26(2), 125-128, 2015
… る．歯周病と脳卒中との関連に関して，歯周炎による脳卒中の発症への影響が報告されている．脳梗塞患者の病型別における各種歯周病菌の血清中抗体価の検討により，歯周病菌の一つであるprevotella intermedia に対する抗体価がアテローム血栓性脳梗塞において高値を示しており，頸動脈のアテローム動脈硬化病変との関連性が示唆された．また異なる歯周病菌であるporphyromonas gingivalis に対する抗体 …
NAID 130005093680

糖尿病患者における歯周病原細菌の血清抗体価に関する調査

太田淳也,深谷千絵,笠井俊輔,赤松真也子,森川暁,田子森順子,江口徹,税所芳史,河合俊英,伊藤裕,中川種昭
日本歯周病学会会誌 56(4), 414-422, 2015
… 抗体価検査はPorphyromonas gingivalis(Pg), Prevotella intermedia(Pi),Eikenella corrodens(Ec), Aggregatibacter actinomycetemcomitans(Aa)の4菌種に行った。 …
NAID 130004842587

Prevotella intermedia Induces Severe Bacteremic Pneumococcal Pneumonia in Mice with Upregulated Platelet-Activating Factor Receptor Expression

Nagaoka Kentaro,Yanagihara Katsunori,Morinaga Yoshitomo,Nakamura Shigeki,Harada Tatsuhiko,Hasegawa Hiroo,Izumikawa Koichi,Ishimatsu Yuji,Kakeya Hiroshi,Nishimura Masaharu,Kohno Shigeru
Infection and Immunity 82(2), 587-593, 2014-02
… In this study, we examined the synergic effects of Prevotella intermedia, a major periodontopathic bacterium, on pneumococcal pneumonia. … intermedia (PiSup) on pneumococcal pneumonia were investigated in mice, and the stimulation of pneumococcal adhesion to human alveolar (A549) cells by PiSup was assessed. … intermedia has the potential to induce severe bacteremic pneumococcal pneumonia with enhanced pneumococcal adhesion to lower airway cells. …
NAID 120005439024