WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

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Grant CM1.
Prion.Prion.2015 Aug 12:0. [Epub ahead of print]
The molecular basis by which fungal and mammalian prions arise spontaneously is poorly understood. A number of different environmental stress conditions are known to increase the frequency of yeast [PSI+] prion formation in agreement with the idea that conditions which cause protein misfolding may p
PMID 26267336

Antioxidant Peroxiredoxin 6 protein rescues toxicity due to oxidative stress and cellular hypoxia in vitro, and attenuates prion-related pathology in vivo.

Asuni AA1, Guridi M2, Sanchez S2, Sadowski MJ3.
Neurochemistry international.Neurochem Int.2015 Aug 8. pii: S0197-0186(15)30034-6. doi: 10.1016/j.neuint.2015.08.006. [Epub ahead of print]
Protein misfolding, mitochondrial dysfunction and oxidative stress are common pathomechanisms that underlie neurodegenerative diseases. In prion disease, central to these processes is the post-translational transformation of cellular prion protein (PrPc) to the aberrant conformationally altered isof
PMID 26265052

Domain-Specific Activation of Death-Associated Intracellular Signalling Cascades by the Cellular Prion Protein in Neuroblastoma Cells.

Vilches S1, Vergara C, Nicolás O, Mata Á, Del Río JA, Gavín R.
Molecular neurobiology.Mol Neurobiol.2015 Aug 7. [Epub ahead of print]
The biological functions of the cellular prion protein remain poorly understood. In fact, numerous studies have aimed to determine specific functions for the different protein domains. Studies of cellular prion protein (PrPC) domains through in vivo expression of molecules carrying internal deletion
PMID 26250617

Comparison of the Anti-Prion Mechanism of Four Different Anti-Prion Compounds, Anti-PrP Monoclonal Antibody 44B1, Pentosan Polysulfate, Chlorpromazine, and U18666A, in Prion-Infected Mouse Neuroblastoma Cells

Yamasaki Takeshi,Suzuki Akio,Hasebe Rie,Horiuchi Motohiro
PLoS ONE 9(9), e106516, 2014-09-02
… Molecules that inhibit the formation of an abnormal　isoform of prion protein (PrPSc) in prion-infected　cells are candidate therapeutic agents for prion　diseases. … In this study, we extensively analyzed the effects of the anti-PrP monoclonal antibody (mAb) 44B1, pentosan polysulfate (PPS), chlorpromazine (CPZ) and U18666A on the intracellular dynamics of a cellular isoform of prion protein (PrPC) and PrPSc in prion-infected mouse neuroblastoma cells to re-evaluate the effects of those agents. …
NAID 120005476205

Age-Dependent Impairment of Eyeblink Conditioning in Prion Protein-Deficient Mice

Kishimoto Yasushi,Hirono Moritoshi,Atarashi Ryuichiro,Sakaguchi Suehiro,Yoshioka Tohru,Katamine Shigeru,Kirino Yutaka
PLoS ONE 8(4), e60627, 2013-04-10
… Mice lacking the prion protein (PrPC) gene (Prnp), Ngsk Prnp0/0 mice, show late-onset cerebellar Purkinje cell (PC) degeneration because of ectopic overexpression of PrPC-like protein (PrPLP/Dpl). … Because PrPC is highly expressed in cerebellar neurons (including PCs and granule cells), it may be involved in cerebellar synaptic function and cerebellar cognitive function. …
NAID 120005289645

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Food Safety 1(1), 2013005-2013005, 2013
… In these diseases, the pathogenic prion protein (PrPSc) enters the host through the gastrointestinal tract and migrates to the central nervous system, where PrPSc induces characteristic pathological changes. … Based on Western Blot with specific markers, liquid chromatography, and morphological analysis, the cellular prion protein (PrPC) and PrPSc in the cells are associated with exosomes, membranous vesicles that are secreted upon fusion of multivesicular endosomes with the plasma membranes. …
NAID 130004591215