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the 16th letter of the Roman alphabet (同)p
a river in western Thailand; a major tributary of the Chao Phraya (同)Ping River

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parking
phosphorusの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/13 01:20:17」(JST)

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Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.^[3]

Function

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development.[Citation needed] The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.^[4]

Interactions

SPI1 has been shown to interact with:

FUS,^[5]
GATA2,^[6]
IRF4,^[7]^[8] and
NONO.^[9]

References

^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Ray D, Culine S, Tavitain A, Moreau-Gachelin F (July 1990). "The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors". Oncogene. 5 (5): 663–8. PMID 1693183.
^ "Entrez Gene: SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1".
^ Hallier M, Lerga A, Barnache S, Tavitian A, Moreau-Gachelin F (February 1998). "The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS". J. Biol. Chem. 273 (9): 4838–42. doi:10.1074/jbc.273.9.4838. PMID 9478924.
^ Zhang P, Behre G, Pan J, Iwama A, Wara-Aswapati N, Radomska HS, Auron PE, Tenen DG, Sun Z (July 1999). "Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1". Proc. Natl. Acad. Sci. U.S.A. 96 (15): 8705–10. doi:10.1073/pnas.96.15.8705. PMC 17580. PMID 10411939.
^ Brass AL, Zhu AQ, Singh H (February 1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers". EMBO J. 18 (4): 977–91. doi:10.1093/emboj/18.4.977. PMC 1171190. PMID 10022840.
^ Escalante CR, Shen L, Escalante MC, Brass AL, Edwards TA, Singh H, Aggarwal AK (July 2002). "Crystallization and characterization of PU.1/IRF-4/DNA ternary complex". J. Struct. Biol. 139 (1): 55–9. doi:10.1016/s1047-8477(02)00514-2. PMID 12372320.
^ Hallier M, Tavitian A, Moreau-Gachelin F (May 1996). "The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb". J. Biol. Chem. 271 (19): 11177–81. doi:10.1074/jbc.271.19.11177. PMID 8626664.

External links

FactorBook PU.1

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 骨髄造血の制御 regulation of myelopoiesis
2. 赤血球産生調節 regulation of erythropoiesis
3. 急性骨髄性白血病の分子遺伝学 molecular genetics of acute myeloid leukemia
4. ヘルパーT細胞サブセット：疾患における分化および役割 t helper subsets differentiation and role in disease
5. リードスタンバーグ細胞およびホジキンリンパ腫の病因 the reed sternberg cell and the pathogenesis of hodgkin lymphoma

English Journal

Regulation of B Cell Linker Protein Transcription by PU.1 and Spi-B in Murine B Cell Acute Lymphoblastic Leukemia.

Xu LS, Sokalski KM, Hotke K, Christie DA, Zarnett O, Piskorz J, Thillainadesan G, Torchia J, Dekoter RP.SourceDepartment of Microbiology and Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5C1;
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2012 Oct 1;189(7):3347-54. Epub 2012 Sep 5.
B cell acute lymphoblastic leukemia (B-ALL) is frequently associated with mutations or chromosomal translocations of genes encoding transcription factors. Conditional deletion of genes encoding the E26-transformation-specific transcription factors, PU.1 and Spi-B, in B cells (ΔPB mice) leads to B-A
PMID 22956576

Japanese Journal

PU.1標的遺伝子の同定による新たな骨髄球系細胞分化機構の解明

生化学 88(2), 233-236, 2016-04
NAID 40020843407

凍結含浸法による動物性食品の物理的変化と嗜好特性

日本調理科学会大会研究発表要旨集 28(0), 11, 2016
NAID 130005264224

「P」

SPI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PUE
Identifiers
Aliases	SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A, Spi-1 proto-oncogene
External IDs	MGI: 98282 HomoloGene: 2346 GeneCards: SPI1
Gene ontology
Molecular function	• DNA binding; • sequence-specific DNA binding; • core promoter binding; • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; • RNA polymerase II core promoter proximal region sequence-specific DNA binding; • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding; • protein binding; • RNA binding; • RNA polymerase II transcription factor activity, sequence-specific DNA binding; • RNA polymerase II core promoter sequence-specific DNA binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • RNA polymerase II transcription factor binding; • RNA polymerase II distal enhancer sequence-specific DNA binding; • transcription factor activity, sequence-specific DNA binding; • NFAT protein binding;
Cellular component	• nucleus; • nuclear chromatin; • nucleoplasm;
Biological process	• myeloid leukocyte differentiation; • regulation of transcription, DNA-templated; • cellular response to ethanol; • somatic stem cell population maintenance; • lymphocyte differentiation; • regulation of erythrocyte differentiation; • myeloid dendritic cell differentiation; • negative regulation of transcription from RNA polymerase II promoter; • negative regulation of MHC class II biosynthetic process; • transcription from RNA polymerase II promoter; • lymphoid progenitor cell differentiation; • transcription, DNA-templated; • macrophage differentiation; • anatomical structure regression; • negative regulation of histone H4 acetylation; • negative regulation of gene expression, epigenetic; • vasculature development; • granulocyte differentiation; • apoptotic process involved in blood vessel morphogenesis; • histone H3 acetylation; • erythrocyte differentiation; • hypermethylation of CpG island; • positive regulation of pri-miRNA transcription from RNA polymerase II promoter; • positive regulation of transcription from RNA polymerase II promoter; • negative regulation of transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	6688
	20375
	ENSG00000066336
	ENSMUSG00000002111
	P17947
	P17433
	NM_001080547; NM_003120
	NM_011355
	NP_001074016; NP_003111
	NP_035485.1; NP_035485
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

[1] "Human PubMed Reference:".

[2] "Mouse PubMed Reference:".

[pmid1693183-3] Ray D, Culine S, Tavitain A, Moreau-Gachelin F (July 1990). "The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors". Oncogene. 5 (5): 663–8. PMID 1693183.

[4] "Entrez Gene: SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1".

[pmid9478924-5] Hallier M, Lerga A, Barnache S, Tavitian A, Moreau-Gachelin F (February 1998). "The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS". J. Biol. Chem. 273 (9): 4838–42. doi:10.1074/jbc.273.9.4838. PMID 9478924.

[pmid10411939-6] Zhang P, Behre G, Pan J, Iwama A, Wara-Aswapati N, Radomska HS, Auron PE, Tenen DG, Sun Z (July 1999). "Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1". Proc. Natl. Acad. Sci. U.S.A. 96 (15): 8705–10. doi:10.1073/pnas.96.15.8705. PMC 17580. PMID 10411939.

[pmid10022840-7] Brass AL, Zhu AQ, Singh H (February 1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers". EMBO J. 18 (4): 977–91. doi:10.1093/emboj/18.4.977. PMC 1171190. PMID 10022840.

[pmid12372320-8] Escalante CR, Shen L, Escalante MC, Brass AL, Edwards TA, Singh H, Aggarwal AK (July 2002). "Crystallization and characterization of PU.1/IRF-4/DNA ternary complex". J. Struct. Biol. 139 (1): 55–9. doi:10.1016/s1047-8477(02)00514-2. PMID 12372320.

[pmid8626664-9] Hallier M, Tavitian A, Moreau-Gachelin F (May 1996). "The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb". J. Biol. Chem. 271 (19): 11177–81. doi:10.1074/jbc.271.19.11177. PMID 8626664.

匿名

検索

案内

案内

PU.1