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the ratio of the circumference to the diameter of a circle; approximately equal to 3.14159265358979323846...
the 16th letter of the Greek alphabet
the 16th letter of the Roman alphabet (同)p
an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
a river in western Thailand; a major tributary of the Chao Phraya (同)Ping River

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〈C〉パイ(ギリシア語アルファベットの第16字Π,π;英語のP,pに相当) / 〈U〉円周率(記号はπ)
ごちゃまぜの活字 / ごちゃまぜ,混乱
parking
phosphorusの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/01/24 02:29:47」(JST)

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Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositide 3-kinases, phosphatidylinositol-3-kinases, PI 3-kinases, PI(3)Ks, PI-3Ks or by the HUGO official stem symbol for the gene family, PI3K(s)) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.

PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns).^[2] The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in insensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.^[3]^[4]

1 Discovery
2 Classes
- 2.1 Class I
- 2.2 Classes II and III
- 2.3 Class IV
3 Human genes
4 Mechanism
5 Function
- 5.1 Mechanism
- 5.2 Cancers
- 5.3 Learning and memory
6 PI 3-kinases as protein kinases
7 Inhibition
- 7.1 PI 3-kinases inhibitors as therapeutics
8 See also
9 References
10 Further reading
11 External links

Discovery

The discovery of PI 3-kinases by Lewis Cantley and colleagues began with their identification of a previously unknown phosphoinositide kinase associated with the polyoma middle T protein.^[5] They observed unique substrate specificity and chromatographic properties of the products of the lipid kinase, leading to the discovery that this phosphoinositide kinase had the unprecedented ability to phosphorylate phosphoinositides on the 3' position of the inositol ring.^[6] Subsequently, Cantley and colleagues demonstrated that in vivo the enzyme prefers PtdIns(4,5)P2 as a substrate, producing the novel phosphoinositide PtdIns(3,4,5)P3^[7] previously identified in neutrophils^[8]

Classes

The phosphoinositol-3-kinase family is divided into four different classes: Class I, Class II, Class III, and Class IV. The classifications are based on primary structure, regulation, and in vitro lipid substrate specificity.^[9]

Class I

Class I PI3Ks are responsible for the production of phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P₂), and phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P₃).^[10] The PI3K is activated by G protein-coupled receptors and tyrosine kinase receptors.^[9]

Class I PI3K are heterodimeric molecules composed of a regulatory and a catalytic subunit; they are further divided between IA and IB subsets on sequence similarity. Class IA PI3K is composed of a heterodimer between a p110 catalytic subunit and a p85 regulatory subunit.^[11] There are five variants of the p85 regulatory subunit, designated p85α, p55α, p50α, p85β, and p55γ. There are also three variants of the p110 catalytic subunit designated p110α, β, or δ catalytic subunit. The first three regulatory subunits are all splice variants of the same gene (Pik3r1), the other two being expressed by other genes (Pik3r2 and Pik3r3, p85β, and p55γ, respectively). The most highly expressed regulatory subunit is p85α; all three catalytic subunits are expressed by separate genes (Pik3ca, Pik3cb, and Pik3cd for p110α, p110β, and p110δ, respectively). The first two p110 isoforms (α and β) are expressed in all cells, but p110δ is expressed primarily in leukocytes, and it has been suggested that it evolved in parallel with the adaptive immune system. The regulatory p101 and catalytic p110γ subunits comprise the class IB PI3Ks and are encoded by a single gene each.

The p85 subunits contain SH2 and SH3 domains (Online Mendelian Inheritance in Man (OMIM) 171833). The SH2 domains bind preferentially to phosphorylated tyrosine residues in the amino acid sequence context Y-X-X-M.^[12]^[13]

Classes II and III

Overview of signal transduction pathways involved in apoptosis.

Class II and III PI3K are differentiated from the Class I by their structure and function. The distinct feature of Class II PI3Ks is the C-terminal C2 domain. This domain lacks critical Asp residues to coordinate binding of Ca²⁺, which suggests class II PI3Ks bind lipids in a Ca²⁺-independent manner.

Class II comprises three catalytic isoforms (C2α, C2β, and C2γ), but, unlike Classes I and III, no regulatory proteins. Class II catalyse the production of PI(3)P from PI and PI(3,4)P₂ from PIP; however, little is known about their role in immune cells. C2α and C2β are expressed through the body, but expression of C2γ is limited to hepatocytes.

Class III produces only PI(3)P from PI ^[9] but are more similar to Class I in structure, as they exist as heterodimers of a catalytic (Vps34) and a regulatory (Vps15/p150) subunits. Class III seems to be primarily involved in the trafficking of proteins and vesicles. There is, however, evidence to show that they are able to contribute to the effectiveness of several process important to immune cells, not least phagocytosis.

Class IV

A group of more distantly related enzymes are sometimes referred to as class IV PI 3-kinases. It is composed of ataxia telangiectasia mutated (ATM), ataxia telangiectasia and Rad3 related (ATR), DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR). They are protein serine/threonine kinases.

Human genes

group	gene	protein	aliases	EC number
class 1 catalytic	PIK3CA	PI3K, catalytic, alpha polypeptide	p110-α	2.7.1.153
	PIK3CB	PI3K, catalytic, beta polypeptide	p110-β
	PIK3CG	PI3K, catalytic, gamma polypeptide	p110-γ
	PIK3CD	PI3K, catalytic, delta polypeptide	p110-δ
class 1 regulatory	PIK3R1	PI3K, regulatory subunit 1 (alpha)	p85-α	N/A
	PIK3R2	PI3K, regulatory subunit 2 (beta)	p85-β
	PIK3R3	PI3K, regulatory subunit 3 (gamma)	p55-γ
	PIK3R4	PI3K, regulatory subunit 4	p150
	PIK3R5	PI3K, regulatory subunit 5	p101
	PIK3R6	PI3K, regulatory subunit 6	p87
class 2	PIK3C2A	PI3K, class 2, alpha polypeptide	PI3K-C2α	2.7.1.154
	PIK3C2B	PI3K, class 2, beta polypeptide	PI3K-C2β
	PIK3C2G	PI3K, class 2, gamma polypeptide	PI3K-C2γ
class 3	PIK3C3	PI3K, class 3	Vps34	2.7.1.137

Mechanism

The various 3-phosphorylated phosphoinositides that are produced by PI 3-kinases (PtdIns3P, PtdIns(3,4)P2, PtdIns(3,5)P2, and PtdIns(3,4,5)P3) function in a mechanism by which an assorted group of signalling proteins, containing PX domain, pleckstrin homology domains (PH domains), FYVE domains and other phosphoinositide-binding domains, are recruited to various cellular membranes.

Function

PI 3-kinases have been linked to an extraordinarily diverse group of cellular functions, including cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. Many of these functions relate to the ability of class I PI 3-kinases to activate protein kinase B (PKB, aka Akt) as in the PI3K/AKT/mTOR pathway. The p110δ and p110γ isoforms regulate different aspects of immune responses. PI 3-kinases are also a key component of the insulin signaling pathway. Hence there is great interest in the role of PI 3-kinase signaling in diabetes mellitus.

Mechanism

The pleckstrin homology domain of AKT binds directly to PtdIns(3,4,5)P3 and PtdIns(3,4)P2, which are produced by activated PI 3-kinase.^[14] Since PtdIns(3,4,5)P3 and PtdIns(3,4)P2 are restricted to the plasma membrane, these results in translocation of AKT to the plasma membrane. Likewise, the phosphoinositide-dependent kinase-1 (PDK1 or, rarely referred to as PDPK1) also contains a pleckstrin homology domain that binds directly to PtdIns(3,4,5)P3 and PtdIns(3,4)P2, causing it to also translocate to the plasma membrane upon activation of PI 3-kinase. The interaction of activated PDK1 and AKT allows AKT to become phosphorylated by PDK1 on threonine 308, leading to partial activation of AKT. Full activation of AKT occurs upon phosphorylation of serine 473 by the TORC2 complex of the mTOR protein kinase.

The "PI3-k/AKT" signaling pathway has been shown to be required for an extremely diverse array of cellular activities - most notably cellular proliferation and survival. The phosphatidylinositol 3-kinase/protein kinase B pathway is stimulated in protection of astrocytes from ceramide-induced apoptosis.^[15]

Many other proteins have been identified that are regulated by PtdIns(3,4,5)P3, including Bruton's tyrosine kinase (BTK), General Receptor for Phosphoinositides-1 (GRP1), and the O-linked N-acetylglucosamine (O-GlcNAc) transferase.

Cancers

The class IA PI 3-kinase p110α is mutated in many cancers. Many of these mutations cause the kinase to be more active. It is the single most mutated kinase in glioblastoma, the most malignant primary brain tumor.^[16] The PtdIns(3,4,5)P₃ phosphatase PTEN that antagonises PI 3-kinase signaling is absent from many tumours. In addition, the epidermal growth factor receptor EGFR that functions upstream of PI 3-kinase is mutationally activated or overexpressed in cancer.^[16]^[17] Hence, PI 3-kinase activity contributes significantly to cellular transformation and the development of cancer.

Learning and memory

PI3K has also been implicated in long-term potentiation (LTP). Whether it is required for the expression or the induction of LTP is still debated. In mouse hippocampal CA1 neurons, PI3K is complexed with AMPA receptors and compartmentalized at the postsynaptic density of glutamatergic synapses.^[18] PI3K is phosphorylated upon NMDA receptor-dependent CaMKII activity,^[19] and it then facilitates the insertion of AMPA-R GluR1 subunits into the plasma membrane. This suggests that PI3K is required for the expression of LTP. Furthermore, PI3K inhibitors abolished the expression of LTP in rat hippocampal CA1, but do not affect its induction.^[20] Notably, the dependence of late-phase LTP expression on PI3K seems to decrease over time.^[21]

However, another study found that PI3K inhibitors suppressed the induction, but not the expression, of LTP in mouse hippocampal CA1.^[22] The PI3K pathway also recruits many other proteins downstream, including mTOR,^[23] GSK3β,^[24] and PSD-95.^[23] The PI3K-mTOR pathway leads to the phosphorylation of p70S6K, a kinase that facilitates translational activity,^[25]^[26] further suggesting that PI3K is required for the protein-synthesis phase of LTP induction instead.

PI3Ks interact with the insulin receptor substrate (IRS) to regulate glucose uptake through a series of phosphorylation events.

PI 3-kinases as protein kinases

Many of the PI 3-kinases appear to have a serine/threonine kinase activity in vitro; however, it is unclear whether this has any role in vivo.

Inhibition

All PI 3-kinases are inhibited by the drugs wortmannin and LY294002, although certain members of the class II PI 3-kinase family show decreased sensitivity. Wortmannin shows better efficiency than LY294002 on the hotspot mutation positions (GLU542, GLU545, and HIS1047)^[27]^[28]

PI 3-kinases inhibitors as therapeutics

As wortmannin and LY294002 are broad inhibitors against PI 3-kinases and a number of unrelated proteins at higher concentrations they are too toxic to be used as therapeutics.^{[citation needed]} A number of pharmaceutical companies have recently been working on PI 3-kinase isoform specific inhibitors including the class I PI 3-kinase, p110δ isoform specific inhibitors, IC486068 and IC87114, ICOS Corporation.^{[citation needed]}. GDC-0941 is a highly selective inhibitor of p110α with little activity against mTOR.

References

^ PDB: 2chz; Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM (2006). "A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling". Cell. 125 (4): 733–47. doi:10.1016/j.cell.2006.03.035. PMC 2946820 . PMID 16647110.
^ myo-inositol
^ Giese N (2009). "Cell pathway on overdrive prevents cancer response to dietary restriction". PhysOrg.com. Retrieved 2009-04-22.
^ Kalaany NY, Sabatini DM (April 2009). "Tumours with PI3K activation are resistant to dietary restriction". Nature. 458 (7239): 725–31. doi:10.1038/nature07782. PMC 2692085 . PMID 19279572.
^ Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM (1985). "Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation". Nature. 315 (6016): 239–42. doi:10.1038/315239a0. PMID 2987699.
^ Whitman M, Downes CP, Keeler M, Keller T, Cantley L (April 1988). "Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate". Nature. 332 (6165): 644–6. doi:10.1038/332644a0. PMID 2833705.
^ Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC (April 1989). "PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells". Cell. 57 (1): 167–75. doi:10.1016/0092-8674(89)90182-7. PMID 2467744.
^ Traynor-Kaplan AE, Harris AL, Thompson BL, Taylor P, Sklar LA (July 1988). "An inositol tetrakisphosphate-containing phospholipid in activated neutrophils". Nature. 334 (6180): 353–6. doi:10.1038/334353a0. PMID 3393226.
^ ^a ^b ^c Leevers SJ, Vanhaesebroeck B, Waterfield MD (April 1999). "Signalling through phosphoinositide 3-kinases: the lipids take centre stage". Current Opinion in Cell Biology. 11 (2): 219–25. doi:10.1016/S0955-0674(99)80029-5. PMID 10209156.
^ Okkenhaug K (January 2013). "Signaling by the phosphoinositide 3-kinase family in immune cells". Annual Review of Immunology. 31 (2): 675–704. doi:10.1146/annurev-immunol-032712-095946. PMC 4516760 . PMID 23330955.
^ Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC (November 1990). "Purification and characterization of phosphoinositide 3-kinase from rat liver". The Journal of Biological Chemistry. 265 (32): 19704–11. PMID 2174051.
^ Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ (March 1993). "SH2 domains recognize specific phosphopeptide sequences". Cell. 72 (5): 767–78. doi:10.1016/0092-8674(93)90404-E. PMID 7680959.
^ Yoakim M, Hou W, Songyang Z, Liu Y, Cantley L, Schaffhausen B (September 1994). "Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity". Molecular and Cellular Biology. 14 (9): 5929–38. doi:10.1128/MCB.14.9.5929. PMC 359119 . PMID 8065326.
^ Franke TF, Kaplan DR, Cantley LC, Toker A (January 1997). "Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate". Science. 275 (5300): 665–8. doi:10.1126/science.275.5300.665. PMID 9005852.
^ Gómez Del Pulgar T, De Ceballos ML, Guzmán M, Velasco G (September 2002). "Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway". The Journal of Biological Chemistry. 277 (39): 36527–33. doi:10.1074/jbc.M205797200. PMID 12133838.
^ ^a ^b Bleeker FE, Lamba S, Zanon C, Molenaar RJ, Hulsebos TJ, Troost D, van Tilborg AA, Vandertop WP, Leenstra S, van Noorden CJ, Bardelli A (September 2014). "Mutational profiling of kinases in glioblastoma". BMC Cancer. 14: 718. doi:10.1186/1471-2407-14-718. PMID 25256166.
^ Bleeker FE, Molenaar RJ, Leenstra S (May 2012). "Recent advances in the molecular understanding of glioblastoma". Journal of Neuro-Oncology. 108 (1): 11–27. doi:10.1007/s11060-011-0793-0. PMC 3337398 . PMID 22270850.
^ Man HY, Wang Q, Lu WY, Ju W, Ahmadian G, Liu L, D'Souza S, Wong TP, Taghibiglou C, Lu J, Becker LE, Pei L, Liu F, Wymann MP, MacDonald JF, Wang YT (May 2003). "Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons". Neuron. 38 (4): 611–24. doi:10.1016/S0896-6273(03)00228-9. PMID 12765612.
^ Joyal JL, Burks DJ, Pons S, Matter WF, Vlahos CJ, White MF, Sacks DB (November 1997). "Calmodulin activates phosphatidylinositol 3-kinase". The Journal of Biological Chemistry. 272 (45): 28183–6. doi:10.1074/jbc.272.45.28183. PMID 9353264.
^ Sanna PP, Cammalleri M, Berton F, Simpson C, Lutjens R, Bloom FE, Francesconi W (May 2002). "Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region". The Journal of Neuroscience. 22 (9): 3359–65. PMID 11978812.
^ Karpova A, Sanna PP, Behnisch T (February 2006). "Involvement of multiple phosphatidylinositol 3-kinase-dependent pathways in the persistence of late-phase long term potentiation expression". Neuroscience. 137 (3): 833–41. doi:10.1016/j.neuroscience.2005.10.012. PMID 16326012.
^ Opazo P, Watabe AM, Grant SG, O'Dell TJ (May 2003). "Phosphatidylinositol 3-kinase regulates the induction of long-term potentiation through extracellular signal-related kinase-independent mechanisms". The Journal of Neuroscience. 23 (9): 3679–88. PMID 12736339.
^ ^a ^b Yang PC, Yang CH, Huang CC, Hsu KS (February 2008). "Phosphatidylinositol 3-kinase activation is required for stress protocol-induced modification of hippocampal synaptic plasticity". The Journal of Biological Chemistry. 283 (5): 2631–43. doi:10.1074/jbc.M706954200. PMID 18057005.
^ Peineau S, Taghibiglou C, Bradley C, Wong TP, Liu L, Lu J, Lo E, Wu D, Saule E, Bouschet T, Matthews P, Isaac JT, Bortolotto ZA, Wang YT, Collingridge GL (March 2007). "LTP inhibits LTD in the hippocampus via regulation of GSK3beta". Neuron. 53 (5): 703–17. doi:10.1016/j.neuron.2007.01.029. PMID 17329210.
^ Toker A, Cantley LC (June 1997). "Signalling through the lipid products of phosphoinositide-3-OH kinase". Nature. 387 (6634): 673–6. doi:10.1038/42648. PMID 9192891.
^ Cammalleri M, Lütjens R, Berton F, King AR, Simpson C, Francesconi W, Sanna PP (November 2003). "Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1". Proceedings of the National Academy of Sciences of the United States of America. 100 (24): 14368–73. doi:10.1073/pnas.2336098100. PMC 283598 . PMID 14623952.
^ Kumar DT, Doss CG (2016-01-01). "Investigating the Inhibitory Effect of Wortmannin in the Hotspot Mutation at Codon 1047 of PIK3CA Kinase Domain: A Molecular Docking and Molecular Dynamics Approach". Advances in Protein Chemistry and Structural Biology. 102: 267–97. doi:10.1016/bs.apcsb.2015.09.008. PMID 26827608.
^ Sudhakar N, Priya Doss CG, Thirumal Kumar D, Chakraborty C, Anand K, Suresh M (2016-01-02). "Deciphering the impact of somatic mutations in exon 20 and exon 9 of PIK3CA gene in breast tumors among Indian women through molecular dynamics approach". Journal of Biomolecular Structure & Dynamics. 34 (1): 29–41. doi:10.1080/07391102.2015.1007483. PMID 25679319.

External links

Eukaryotic Linear Motif resource motif class MOD_PIKK_1
Proteopedia Phosphoinositide_3-Kinases to explore the structure in interactive 3D
PI-3 Kinase at the US National Library of Medicine Medical Subject Headings (MeSH)
PI3K/Akt Signaling Pathway

UpToDate Contents

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1. 腸壁気腫症 pneumatosis intestinalis
2. T細胞受容体シグナル伝達 t cell receptor signaling
3. インスリン様成長因子Iの生理学 physiology of insulin like growth factor 1
4. マントル細胞リンパ腫の病理学 pathobiology of mantle cell lymphoma
5. 血小板生物学 platelet biology

English Journal

Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl.

Manganaro D1, Consonni A1, Guidetti GF1, Canobbio I1, Visconte C1, Kim S2, Okigaki M3, Falasca M4, Hirsch E5, Kunapuli SP2, Torti M6.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Aug;1850(8):1879-88. doi: 10.1016/j.bbamcr.2015.05.004. Epub 2015 May 8.
Phosphatidylinositol 3-kinaseβ (PI3Kβ) plays a predominant role in integrin outside-in signaling and in platelet activation by GPVI engagement. We have shown that the tyrosine kinase Pyk2 mediates PI3Kβ activation downstream of integrin αIIbβ3, and promotes the phosphorylation of the PI3K-assoc
PMID 25960397

Growth-factor dependent expression of the translationally controlled tumour protein TCTP is regulated through the PI3-K/Akt/mTORC1 signalling pathway.

Bommer UA1, Iadevaia V2, Chen J3, Knoch B3, Engel M3, Proud CG2.
Cellular signalling.Cell Signal.2015 Aug;27(8):1557-68. doi: 10.1016/j.cellsig.2015.04.011. Epub 2015 Apr 30.
Translationally controlled tumour protein TCTP (gene symbol: TPT1) is a highly-conserved, cyto-protective protein implicated in many physiological and disease processes, in particular cancer, where it is associated with poor patient outcomes. To understand the mechanisms underlying the accumulation
PMID 25936523

Japanese Journal

Molecular signaling mechanisms that mediate exercise training effects on insulin sensitivity

The journal of physical fitness and sports medicine : JPFSM 2(1), 117-119, 2013-03-25
NAID 10031159025

PAK1-deficiency/down-regulation reduces brood size, activates HSP16.2 gene and extends lifespan in Caenorhabditis elegans

Drug Discoveries & Therapeutics 7(1), 29-35, 2013
NAID 130005054758

「PI3-kinase」

Phosphoinositide 3-kinase
Identifiers
EC number	2.7.1.137
CAS number	115926-52-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search
PMC	articles
PubMed	articles
NCBI	proteins

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Phosphatidylinositol-4,5-bisphosphate 3-kinase
	PIK-93 inhibitor (yellow) bound to the PI3 Kinase 110 gamma subunit .
Identifiers
Symbol	PI3K
Pfam	PF00454
InterPro	IPR000403
SMART	SM00146
PROSITE	PDOC00710
SCOP	3gmm
SUPERFAMILY	3gmm
OPM superfamily	302
OPM protein	3ml9
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

　　[★]

ホスファチジルイノシトール3キナーゼ、ホスホイノシチド3キナーゼ、イノシトールリン脂質3キナーゼ、PI3-キナーゼ、PI3キナーゼ

関: 1-phosphatidylinositol 3-kinase、phosphatidylinositol 3-kinase、phosphoinositide 3-kinase、PI 3-kinase、PI-3 kinase、PI-3K、PI3K、PtdIns 3-kinase

「PI 3-kinase」

　　[★]

ホスファチジルイノシトール3キナーゼ、ホスホイノシチド3キナーゼ、イノシトールリン脂質3キナーゼ、PI-3キナーゼ

関: 1-phosphatidylinositol 3-kinase、phosphatidylinositol 3-kinase、phosphoinositide 3-kinase、PI-3 kinase、PI-3K、PI3-kinase、PI3K、PtdIns 3-kinase

「PI-3K」

　　[★]

ホスファチジルイノシトール3キナーゼ、ホスホイノシチド3キナーゼ

関: 1-phosphatidylinositol 3-kinase、phosphatidylinositol 3-kinase、phosphoinositide 3-kinase、PI 3-kinase、PI-3 kinase、PI3-kinase、PI3K、PtdIns 3-kinase

「PtdIns 3-kinase」

　　[★]

ホスファチジルイノシトール-3-キナーゼ

関: 1-phosphatidylinositol 3-kinase、phosphatidylinositol 3-kinase、PI 3-kinase、PI-3 kinase、PI-3K、PI3-kinase

「1-phosphatidylinositol 3-kinase」

　　[★]

1-ホスファチジルイノシトール-3-キナーゼ

関: phosphatidylinositol 3-kinase、PI 3-kinase、PI-3 kinase、PI-3K、PI3-kinase、PtdIns 3-kinase

「PI」

　　[★]

肺動脈弁閉鎖不全症 pulmonary insufficiency
ホスファチジルイノシトール phosphatidyl inositol PtdIns
ホスホイノシチド
肺梗塞 pulmonary infarction

「kinase」

　　[★] キナーゼカイネースリン酸化酵素 phosphoenzyme phosphotransferase 　

「P」

　　[★]

[pmid16647110-1] PDB: 2chz; Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM (2006). "A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling". Cell. 125 (4): 733–47. doi:10.1016/j.cell.2006.03.035. PMC 2946820 . PMID 16647110.

[2] yo-inositol

[urlCell_pathway_on_overdrive_prevents_cancer_response_to_dietary_restriction-3] Giese N (2009). "Cell pathway on overdrive prevents cancer response to dietary restriction". PhysOrg.com. Retrieved 2009-04-22.

[pmid19279572-4] Kalaany NY, Sabatini DM (April 2009). "Tumours with PI3K activation are resistant to dietary restriction". Nature. 458 (7239): 725–31. doi:10.1038/nature07782. PMC 2692085 . PMID 19279572.

[5] Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM (1985). "Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation". Nature. 315 (6016): 239–42. doi:10.1038/315239a0. PMID 2987699.

[Whitman-6] Whitman M, Downes CP, Keeler M, Keller T, Cantley L (April 1988). "Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate". Nature. 332 (6165): 644–6. doi:10.1038/332644a0. PMID 2833705.

[Auger-7] Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC (April 1989). "PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells". Cell. 57 (1): 167–75. doi:10.1016/0092-8674(89)90182-7. PMID 2467744.

[8] Traynor-Kaplan AE, Harris AL, Thompson BL, Taylor P, Sklar LA (July 1988). "An inositol tetrakisphosphate-containing phospholipid in activated neutrophils". Nature. 334 (6180): 353–6. doi:10.1038/334353a0. PMID 3393226.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

リンク元	「PI3-kinase」「PI 3-kinase」「PI-3K」「PtdIns 3-kinase」「1-phosphatidylinositol 3-kinase」
関連記事	「PI」「kinase」「P」

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PI-3 kinase

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Contents

Discovery

Classes

Class I

Classes II and III

Class IV

Human genes

Mechanism

Function

Mechanism

Cancers

Learning and memory

PI 3-kinases as protein kinases

Inhibition

PI 3-kinases inhibitors as therapeutics

See also

References

Further reading

External links

UpToDate Contents

English Journal

Japanese Journal

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★リンクテーブル★

「PI3-kinase」

「PI 3-kinase」

「PI-3K」

「PtdIns 3-kinase」

「1-phosphatidylinositol 3-kinase」

「PI」

「kinase」

「P」