PHA

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/01/08 03:42:44」(JST)

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英文文献

  • Polyhydroxyalkanoate Synthesis Affects Biosurfactant Production and Cell Attachment to Hydrocarbons in Pseudomonas sp. KA-08.
  • Di Martino C1, Catone MV, López NI, Raiger Iustman LJ.Author information 1Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160, C1428EGA, Buenos Aires, Argentina.AbstractStressful conditions prevailing in hydrocarbon-contaminated sites influence the diversity, distribution, and activities of microorganisms. Oil bioremediation agents should develop special characteristics to cope with these environments like surfactant production and cellular affinity to hydrocarbons. Additionally, polyhydroxyalkanoate (PHA) accumulation was proven to improve tolerance to stressful conditions. Pseudomonas sp. KA-08 was isolated from a chronic oil-contaminated environment, it is highly tolerant to xylene, and it is able to accumulate PHA and to produce surfactant compounds that lower the water surface tension (ST) as well as bioemulsifiers. In this work, we studied the effect of the capability to accumulate PHAs on biosurfactant production and microbial attachment to hydrocarbons (MATH). Our results showed that PHA synthesis capability has a favorable effect in the production of compounds which affect the ST but not on the production of bioemulsifiers. On the other hand, PHA accumulation affects cellular affinity to xylene. MATH analysis showed that a PHA-negative mutant increased its affinity to xylene compared with the wild-type strain. This result was also observed in Pseudomonas putida GPp104 (a PHA(-) mutant), suggesting that this effect could be generalized to other Pseudomonas strains.
  • Current microbiology.Curr Microbiol.2014 Jun;68(6):735-42. doi: 10.1007/s00284-014-0536-5. Epub 2014 Feb 12.
  • Stressful conditions prevailing in hydrocarbon-contaminated sites influence the diversity, distribution, and activities of microorganisms. Oil bioremediation agents should develop special characteristics to cope with these environments like surfactant production and cellular affinity to hydrocarbons
  • PMID 24519857
  • System A amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts.
  • Nishimura T1, Yagi R1, Usuda M1, Oda K1, Yamazaki M1, Suda S1, Takahashi Y1, Okazaki F1, Sai Y2, Higuchi K3, Maruyama T4, Tomi M5, Nakashima E1.Author information 1Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan.2Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan; Department of Pharmacy, Kanazawa University Hospital, Takara-machi 13-1, Kanazawa 920-0841, Japan.3Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan; School of Pharmaceutical Sciences, Teikyo University, Itabashi-ku 173-8605, Tokyo, Japan.4Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku 160-8512, Tokyo, Japan.5Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan. Electronic address: tomi-ms@pha.keio.ac.jp.AbstractBetaine uptake is induced by hypertonic stress in a placental trophoblast cell line, and involvement of amino acid transport system A was proposed. Here, we aimed to identify the subtype(s) of system A that mediates hypertonicity-induced betaine uptake. Measurement of [(14)C]betaine uptake by HEK293 cells transiently transfected with human or rat sodium-coupled neutral amino acid transporters (SNATs), SNAT1, SNAT2 and SNAT4 revealed that only human and rat SNAT2 have betaine uptake activity. The Michaelis constants (Km) of betaine uptake by human and rat SNAT2 were estimated to be 5.3mM and 4.6mM, respectively. Betaine exclusively inhibited the uptake activity of SNAT2 among the rat system A subtypes. We found that rat SNAT1, SNAT2 and SNAT4 were expressed at the mRNA level under isotonic conditions, while expression of SNAT2 and SNAT4 was induced by hypertonicity in TR-TBT 18d-1 cells. Western blot analyses revealed that SNAT2 expression on plasma membrane of TR-TBT 18d-1 cells was more potently induced by hypertonicity than that in total cell lysate. Immunocytochemistry confirmed the induction of SNAT2 expression in TR-TBT 18d-1 cells exposed to hypertonic conditions and indicated that SNAT2 was localized on the plasma membrane in these cells. Our results indicate that SNAT2 transports betaine, and that tonicity-sensitive SNAT2 expression may be involved in regulation of betaine concentration in placental trophoblasts.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2014 May;1838(5):1306-12. doi: 10.1016/j.bbamem.2014.01.004. Epub 2014 Jan 14.
  • Betaine uptake is induced by hypertonic stress in a placental trophoblast cell line, and involvement of amino acid transport system A was proposed. Here, we aimed to identify the subtype(s) of system A that mediates hypertonicity-induced betaine uptake. Measurement of [(14)C]betaine uptake by HEK293
  • PMID 24434061
  • The Properties of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) and its Applications in Tissue Engineering.
  • Yang Q, Wang J, Zhang S, Tang X, Shang G, Peng Q, Wang R, Cai X1.Author information 1Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301., Middle Yanchang Road, Shanghai 200072, P.R. China. raoraowang@tongji.edu.cn.AbstractPoly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) is a member of the polyhydroxyalkanoate (PHA) family. It is the designation of molecules consisting of random co-polymers of 3-hydroxybutyrate and 3- hydroxyhexanoate. PHBHHx plays a significant role in the field of biomedical materials. It has good physical, chemical and mechanical properties, making it potentially useful for a wide range of biomaterials applications. In addition, it has also shown better biocompatibility with different cell types. This paper will introduce the physical, chemical and biological properties of PHBHHx, including biodegradation, hydrophilicity, surface properties and cytocompatibility. The development of PHBHHx in tissue-engineering applications will be discussed. PHBHHx used to repair bone, cartilage, tendons, nerves and vessels will be the focus of discussion.
  • Current stem cell research & therapy.Curr Stem Cell Res Ther.2014 May;9(3):215-22.
  • Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) is a member of the polyhydroxyalkanoate (PHA) family. It is the designation of molecules consisting of random co-polymers of 3-hydroxybutyrate and 3- hydroxyhexanoate. PHBHHx plays a significant role in the field of biomedical materials. It has
  • PMID 24524792

和文文献

  • Preparation and characterization of fluorinated porcine hydroxyapatite
  • LIU Quan,CHEN Zetao,GU Haijing,CHEN Zhuofan
  • Dental materials journal 31(5), 742-750, 2012-09-01
  • … SEM, XPS, XRD, and FTIR results confirmed the fluorination of porcine hydroxyapatite (PHA). … Significant crystal morphological difference was observed between PHA and FPHA. … Fluoride was successfully incorporated into PHA by chemical and thermal processes in this study. … Fluoride incorporation rate into PHA was a strong function of the fluorine concentration in the immersion solution. …
  • NAID 10030875457
  • Preparative synthesis of Poly〔(R)-3-hydroxybutyrate〕 monomer for enzymatic cell-free polymerization
  • Tomizawa Satoshi,Yoshioka Masako,Ushimaru Kazunori
  • Polymer journal 44(9), 982-985, 2012-09
  • NAID 40019395322

関連リンク

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関連画像

Đang mang thai » Vấn đề thường pha_thai.jpgImage:PHA_pathwaysBig.jpgMain entrance, Pha That Luangphaのフォトライフ - pha Led Pha 20w RGB


★リンクテーブル★
先読み受身赤血球凝集反応」「pulse height analyzer」「phytohemagglutinin
リンク元マイトジェン」「術前栄養管理」「フィトヘマグルチニン」「パルスハイツアナライザー」「偽性低アルドステロン症
拡張検索TPHA」「PHACE syndrome」「TPHAテスト」「TPHA試験
関連記事P」「PH

受身赤血球凝集反応」

  [★]

passive hemagglutination
受身血球凝集反応、感作赤血球凝集反応 感作血球凝集反応 sensitized hemagglutination、間接赤血球凝集反応 indirect hemagglutination
[show details]



pulse height analyzer」

  [★] パルスハイツアナライザー


phytohemagglutinin」

  [★] フィトヘマグルチニン

マイトジェン」

  [★]

mitogen
有糸分裂促進剤分裂促進因子 mitogenic factor


  • T cell mitogen
  • B cell mitogen
LAB.783
  • T細胞:特異抗原、抗T細胞抗原レセプター抗体、抗CD3抗体、PHA、ConA、スーパー抗原、フォールボールエステル(PMAなど)
  • B細胞:抗IgM抗体、Staphylococcus aureus Cowan I(SAC)、プロテインA
  • T/B細胞:PWM



術前栄養管理」

  [★]

術前管理
  • 1. 身体計測指標
  • 2. 質的評価
  • a. 骨格筋蛋白質量
  • b. 内臓蛋白質量
  • i. アルブミン、蛋白文革
  • ii. UN→N-balance
  • iii. TFN, preALB, RBP
  • iv. リンパ球数、T cell, B cell, PPD, PHA
  • c. 脂肪量 
i. CHO, TG← 内臓脂肪の推定
  • d. その他
  • i. ビタミンA、葉酸、亜鉛
  • ii. IRI, T3, FT3
  • iii. 血清電解質、尿中電解質

栄養療法の適応

  • N-balance < 0
  • %標準体重 < 80%
  • CHI < 80$
  • ALB < 3.0 g/dl
  • TFN < 200 mg/dl
  • リンパ球数 < 1000 /mm3
  • PPD < 5mm

フィトヘマグルチニン」

  [★]

phytohemagglutinin phytohaemagglutinin PHA
植物性凝集素植物性血球凝集素
レクチンマイトジェンリンパ球幼若化試験



パルスハイツアナライザー」

  [★]

pulse height analyzer PHA
波高分析器波高選別器 spectrometer


偽性低アルドステロン症」

  [★]

pseudohypoaldosteronism PHA
偽低アルドステロン症



TPHA」

  [★]


PHACE syndrome」

  [★]

フェイス症候群, PHACE症候群


参考

  • 1.
[display]http://www.komiyama.me/Kodomo/Phace_syndrome.html
  • 2. OMIM
[display]http://omim.org/entry/606519

TPHAテスト」

  [★] 梅毒トレポネーマ感作赤血球凝集試験


TPHA試験」

  [★] 梅毒トレポネーマ感作赤血球凝集試験

P」

  [★]


WordNet   license wordnet

「the 16th letter of the Roman alphabet」
p

PrepTutorEJDIC   license prepejdic

「parking」

PrepTutorEJDIC   license prepejdic

「phosphorusの化学記号」


PH」

  [★] 肺高血圧症 pulmonary hypertension


"http://meddic.jp/PHA" より作成


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