PFOR

ピルビン酸フェレドキシン酸化還元酵素

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/11 14:52:07」(JST)

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pyruvate synthase
Identifiers
EC number	1.2.7.1
CAS number	9082-51-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a pyruvate synthase (EC 1.2.7.1) is an enzyme that catalyzes the interconversion of pyruvate and acetyl-CoA. It is also called pyruvate:ferredoxin oxidoreductase (PFOR).

The relevant equilibrium catalysed by PFOR is:

pyruvate + CoA + oxidized ferredoxin acetyl-CoA + CO₂ + reduced ferredoxin + 2 H⁺

The 3 substrates of this enzyme are pyruvate, CoA, and oxidized ferredoxin, whereas its 4 products are acetyl-CoA, CO₂, reduced ferredoxin, and H⁺.

Function

This enzyme participates in 4 metabolic pathways: pyruvate metabolism, propanoate metabolism, butanoate metabolism, and reductive carboxylate cycle (CO₂ fixation).

Its major role is the extraction of reducing equivalents by the decarboxylation. In aerobic organisms, this conversion is catalysed by pyruvate dehydrogenase, also uses thiamine pyrophosphate but relies on lipoate as the electron acceptor. Unlike the aerobic enzyme complex PFOR transfers reducing equivalents to flavins or iron-sulflur clusters. This process links glycolysis to the Wood–Ljungdahl pathway.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating). Other names in common use include:

• pyruvate oxidoreductase,
• pyruvate synthetase,
• pyruvate:ferredoxin oxidoreductase, and
• pyruvic-ferredoxin oxidoreductase.

Inhibitors

Amixicile is a potent inhibitor of pyruvate ferredoxin oxidoreductase and is in pre-clinical studies to treat infections of Helicobacter pylori and Clostridium difficile.

References

Further reading

• Evans MC, Buchanan BB (1965). "Photoreduction of ferredoxin and its use in carbon dioxide fixation by a subcellular system from a photosynthetic bacterium". Proc. Natl. Acad. Sci. U.S.A. 53 (6): 1420–5. doi:10.1073/pnas.53.6.1420. PMC 219872. PMID 5217644. 
• Gehring U, Arnon DI (1972). "Purification and properties of -ketoglutarate synthase from a photosynthetic bacterium". J. Biol. Chem. 247 (21): 6963–9. PMID 4628267. 
• Uyeda K, Rabinowitz JC (1971). "Pyruvate-ferredoxin oxidoreductase. 3. Purification and properties of the enzyme". J. Biol. Chem. 246 (10): 3111–9. PMID 5574389. 
• Uyeda K, Rabinowitz JC (1971). "Pyruvate-ferredoxin oxidoreductase. IV. Studies on the reaction mechanism". J. Biol. Chem. 246 (10): 3120–5. PMID 4324891. 
• Charon MH, Volbeda A, Chabriere E, Pieulle L, Fontecilla-Camps JC (1999). "Structure and electron transfer mechanism of pyruvate:ferredoxin oxidoreductase". Curr. Opin. Struct. Biol. 9 (6): 663–9. doi:10.1016/S0959-440X(99)00027-5. PMID 10607667. 

English Journal

• Perinatal microbial exposure may influence aortic intima-media thickness in early infancy.

• McCloskey K1, Vuillermin P2, Carlin JB3, Cheung M3, Skilton MR4, Tang ML3, Allen K3, Gilbert GL5, Ranganathan S3, Collier F6, Dwyer T3, Ponsonby AL7, Burgner D8; BIS Investigator Group.
• International journal of epidemiology.Int J Epidemiol.2016 Apr 8. pii: dyw042. [Epub ahead of print]
• BACKGROUND: The maternal and infant microbiome may influence infant cardiovascular risk through immune programming. The maternal vagino-enteric microbiome is often sampled for group B streptococcus (GBS) colonization during pregnancy. Our aim was to investigate the association between maternal GBS c
• PMID 27059546

• Fruit and Vegetable Intake and Hip Fracture Incidence in Older Men and Women: The CHANCES Project.

• Benetou V1,2, Orfanos P1,2, Feskanich D3, Michaëlsson K4, Pettersson-Kymmer U5, Eriksson S6, Grodstein F7, Wolk A8, Bellavia A8, Ahmed LA9,10, Boffeta P11, Trichopoulou A1,2.
• Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.J Bone Miner Res.2016 Apr 8. doi: 10.1002/jbmr.2850. [Epub ahead of print]
• The role of fruit and vegetable intake in relation to fracture prevention during adulthood and beyond is not adequately understood. We investigated the potential association between fruit and vegetable intake and hip fracture incidence in a large sample of elderly from Europe and United States. A to
• PMID 27061845

• Duration of depressive symptoms and mortality risk: the English Longitudinal Study of Ageing (ELSA).

• White J1, Zaninotto P2, Walters K2, Kivimäki M2, Demakakos P2, Biddulph J2, Kumari M2, De Oliveira C2, Gallacher J2, Batty GD2.
• The British journal of psychiatry : the journal of mental science.Br J Psychiatry.2016 Apr;208(4):337-42. doi: 10.1192/bjp.bp.114.155333. Epub 2016 Jan 21.
• BACKGROUND: The relationship between the duration of depressive symptoms and mortality remains poorly understood.AIMS: To examine whether the duration of depressive symptoms is associated with mortality risk.METHOD: Data (n= 9560) came from the English Longitudinal Study of Ageing (ELSA). We assesse
• PMID 26795425

Japanese Journal

• 携帯端末を用いた自動車の低加速度運転支援システム

• 高橋 陽介,井垣 宏,井上 亮文
• 情報処理学会研究報告. EIP, [電子化知的財産・社会基盤] 2011-EIP-53(6), 1-7, 2011-09-08
• 自動車走行では,車内環境,振動刺激,搭乗者の生理的・心理的要因といった多様な要素が乗り心地に影響を与えることが知られている.しかしながら,既存研究の多くが振動刺激のみを対象として自動車および運転操作による乗り心地を評価している.本研究では,運転者用と同乗者用それぞれの Android アプリケーション (TAKUMI-D および TAKUMI-P) を用いて,同乗者の感じる主観的な要因を考慮した低 …
• NAID 110008606710

• 携帯端末を用いた自動車の低加速度運転支援システム

• 高橋 陽介,井垣 宏,井上 亮文
• 情報処理学会研究報告. GN, [グループウェアとネットワークサービス] 2011-GN-81(6), 1-7, 2011-09-08
• 自動車走行では,車内環境,振動刺激,搭乗者の生理的・心理的要因といった多様な要素が乗り心地に影響を与えることが知られている.しかしながら,既存研究の多くが振動刺激のみを対象として自動車および運転操作による乗り心地を評価している.本研究では,運転者用と同乗者用それぞれの Android アプリケーション (TAKUMI-D および TAKUMI-P) を用いて,同乗者の感じる主観的な要因を考慮した低 …
• NAID 110008606686

Related Links

• PFOR.org

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• PFOR - What does PFOR stand for? The Free Dictionary

Acronym Definition PFOR Pyruvate Ferredoxin Oxidoreductase PFOR Pocket Full of Rocks (Christian band) PFOR Peace Force (UN Peacekeeping) PFOR Proposal For a Peace Force ... 85 excluding VAT (value estimated on the ...

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pyruvate-ferredoxin oxidoreductase, PFOR

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