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1. 肺動脈性肺高血圧症（グループ1）の疫学と発症機序the epidemiology and pathogenesis of pulmonary arterial hypertension group 1 [show details]
… Several lines of evidence support a role for abnormal BMPR2 in PAH: Human – Up to 25 percent of patients with IPAH have abnormal BMPR2 structure or function ,… Mutations in the following genes have been variably associated with familial,… five groups based upon etiology : Group 1 – Pulmonary arterial hypertension (PAH) Group 2 – PH due to left heart disease;…
2. ヒト免疫不全ウイルス（HIV）関連肺動脈性高血圧症pulmonary arterial hypertension associated with human immunodeficiency virus [show details]
… supported by the observation that circulating monocytes from patients with HIV have increased endothelin-1 gene expression . Oxidative stress induced by gp120 (and tat) may lead to endothelial dysfunction and vascular … Human immunodeficiency virus-related pulmonary arterial hypertension (HIV-PAH) refers to pulmonary arterial hypertension (PAH) that develops in a patient who has HIV infection.…
3. 慢性血栓塞栓性肺高血圧症：外科的治療chronic thromboembolic pulmonary hypertension surgical treatment [show details]
… represents an absolute contraindication in that reperfusion of abnormal pulmonary parenchyma will result in minimal symptomatic improvement.… to the treatment of CTEPH is described separately. Surgery is a potentially curative therapy for chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary thromboendarterectomy…
4. 全身性硬化症（強皮症）に伴う肺動脈性高血圧症：定義、分類、危険因子、スクリーニングpulmonary arterial hypertension in systemic sclerosis scleroderma definition classification risk factors and screening [show details]
… In several studies the abnormal exercise response correlated with abnormal lung function,… classification, definition, risk factors, screening, and prognosis of SSc-associated pulmonary arterial hypertension (PAH), specifically group 1 PAH, are reviewed here. Group 2 PH and group 3 PH are discussed …
5. 成人に生じる原因不明の肺高血圧症の臨床的特徴と診断clinical features and diagnosis of pulmonary hypertension of unclear etiology in adults [show details]
… mutations occur in the gene encoding bone morphogenetic protein receptor 2 (BMPR2). Other mutations associated with PAH have been identified in genes encoding activin-like kinase… younger adults or 40 mmHg in older adults, and/or when RV size, wall thickness, and function are abnormal, understanding that PH may still be present even in the absence of these findings. Although estimation … and parasitic obstructions are rare The detection of CTEPH is an important step in the diagnostic evaluation of PH since CTEPH is potentially reversible with surgery.…