血小板活性化因子受容体、血小板活性化因子レセプター、PAF受容体、PAFレセプター

WordNet

the 16th letter of the Roman alphabet (同)p
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

personal assistant個人秘書 / public address [system]
parking
phosphorusの化学記号
=sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/08 11:33:46」(JST)

wiki en

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor.^[1]^[2]

The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM]^[3] Its pathogenetic role in chronic kidney failure has also been reported recently. ^[4]

Ligands

Agonists

Platelet activating factor

Antagonists

Israpafant (Y-24180)
WEB 2086

References

^ Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1". Genomics 13 (3): 832–4. doi:10.1016/0888-7543(92)90162-L. PMID 1322356.
^ Ishii S, Nagase T, Shimizu T (2002). "Platelet-activating factor receptor". Prostaglandins Other Lipid Mediat. 68-69: 599–609. doi:10.1016/S0090-6980(02)00058-8. PMID 12432946.
^ "Entrez Gene: PTAFR platelet-activating factor receptor".
^ Correa-Costa M (Apr 2014). "Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis.". Lab Invest. 94 (4): 455–466. doi:10.1038/labinvest.2013.155. PMID 24492283.

External links

"Platelet-Activating Factor Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
platelet activating factor receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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English Journal

Platelet-Activating Factor Receptor Blockade Ameliorates Aggregatibacter actinomycetemcomitans-Induced Periodontal Disease in Mice.

Madeira MF, Queiroz-Junior CM, Costa GM, Werneck SM, Cisalpino D, Garlet GP, Teixeira MM, Silva TA, Souza DG.SourceDepartment of Microbiology, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Infection and immunity.Infect Immun.2013 Nov;81(11):4244-51. doi: 10.1128/IAI.01046-13. Epub 2013 Sep 3.
Periodontal disease (PD) is a chronic inflammatory and alveolar bone destructive disease triggered by oral biofilm-producing microorganisms, such as Aggregatibacter actinomycetemcomitans. The levels of the phospholipid platelet-activating factor (PAF) in the saliva, gingival crevicular fluid, and pe
PMID 24002061

Staphylococcus aureus Lipoteichoic Acid Inhibits Platelet Activation and Thrombus Formation via the Paf Receptor.

Waller AK, Sage T, Kumar C, Carr T, Gibbins JM, Clarke SR.SourceSchool of Biological Sciences.
The Journal of infectious diseases.J Infect Dis.2013 Oct 21. [Epub ahead of print]
Impaired healing is common in wounds infected with the major human pathogen Staphylococcus aureus, although the underlying mechanisms are poorly understood. Here, we show that S. aureus lipoteichoic acid (LTA) inhibits platelet aggregation caused by physiological agonists and S. aureus and reduced p
PMID 23911710

Rapid desensitization of mice with anti-FcγRIIb/FcγRIII mAb safely prevents IgG-mediated anaphylaxis.

Khodoun MV, Kucuk ZY, Strait RT, Krishnamurthy D, Janek K, Clay CD, Morris SC, Finkelman FD.SourceDepartment of Research, Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio; Division of Immunology, Allergy and Rheumatology, Department of Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio.
The Journal of allergy and clinical immunology.J Allergy Clin Immunol.2013 Oct 18. pii: S0091-6749(13)01429-2. doi: 10.1016/j.jaci.2013.09.008. [Epub ahead of print]
BACKGROUND: Stimulatory IgG receptors (FcγRs) on bone marrow-derived cells contribute to the pathogenesis of several autoimmune and inflammatory disorders. Monoclonal antibodies that block FcγRs might suppress these diseases, but they can induce anaphylaxis.OBJECTIVE: We wanted to determine whethe
PMID 24139828

Japanese Journal

Platelet-Activating Factor and Pain

Tsuda Makoto,Tozaki-Saitoh Hidetoshi,Inoue Kazuhide
Biological & Pharmaceutical Bulletin 34(8), 1159-1162, 2011
… Platelet-activating factor (PAF) is a phospholipid mediator that regulates the functions of a variety of cells in the peripheral tissues and in the nervous system. … Findings that injection of PAF exogenously at the skin or in the spinal cord induced pain hypersensitivity gave us much attention to its role in pain signaling. …
NAID 130000936580

PAFレセプターによるマスト細胞の活性化 (特集マスト細胞・好塩基球の活性化をめぐって)

岡山吉道,権寧博,浅野正岳 [他]
臨床免疫・アレルギー科 54(2), 149-154, 2010-08
NAID 40017285241

PI-36 Immunohistochemical Localization of PAF-receptor and Cross-talk between PAF-and ACTH-induced aldosterone secretion in Guinea Pig Adrenals

Shimada Toshio,Matsumoto Itsuro,Aikawa Tadaomi
日本組織細胞化学会総会プログラムおよび抄録集 (50), 80, 2009-09-26
NAID 110007384838

Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection.

Seki Masafumi,Kosai Kosuke,Hara Atsuko [他]
Japanese journal of infectious diseases 62(1), 6-10, 2009-01
… Platelet-activating factor (PAF) is a critical mediator of severe inflammatory diseases such as pneumonia, and the PAF-receptor (PAFR) is known to be an anchor for Streptococcus pneumoniae attachment to lung epithelial cells. …
NAID 120001253656

Related Pictures

★リンクテーブル★

リンク元	「PAFレセプター」「血小板活性化因子受容体」「血小板活性化因子レセプター」「PAF受容体」
関連記事	「PA」「P」「PAF」

「PAFレセプター」

Platelet-activating factor receptor
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2B0X
Identifiers
Symbols	PTAFR ; PAFR
External IDs	OMIM: 173393 MGI: 106066 HomoloGene: 20260 IUPHAR: 334 ChEMBL: 250 GeneCards: PTAFR Gene
Gene ontology
Molecular function	• lipopolysaccharide binding; • lipopolysaccharide receptor activity; • G-protein coupled receptor activity; • platelet activating factor receptor activity; • phospholipid binding;
Cellular component	• plasma membrane; • integral component of plasma membrane; • membrane; • integral component of membrane;
Biological process	• cytokine production; • chemotaxis; • inflammatory response; • immune response; • G-protein coupled receptor signaling pathway; • cytokine-mediated signaling pathway; • lipopolysaccharide-mediated signaling pathway; • inositol trisphosphate biosynthetic process; • phosphatidylinositol-mediated signaling; • interferon-gamma-mediated signaling pathway;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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