PAF acetylhydrolase

出典: meddic

PAFアセチルヒドロラーゼ血小板活性化因子アセチルヒドロラーゼ

1-alkyl-2-acetylglycerophosphocholine esteraselipoprotein-associated phospholipase A2Lp-PLA2platelet-activating factor acetylhydrolase

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英文文献

  • Bioactive oxidatively truncated phospholipids in inflammation and apoptosis: Formation, targets, and inactivation.
  • McIntyre TM.AbstractThis report reviews structurally related phospholipid oxidation products that are biologically active where molecular mechanisms have been defined. Phospholipids containing polyunsaturated fatty acyl residues are chemically or enzymatically oxidized to phospholipid hydroperoxides, which may fragment on either side of the newly introduced peroxy function to form phospholipids with a truncated sn-2 residue. These truncated phospholipids not subject to biologic control of their production and, depending on the sn-2 residue length and structure, can stimulate the plasma membrane receptor for PAF. Alternatively, these chemically formed products can be internalized by a transport system to either stimulate the lipid activated nuclear transcription factor PPARγ or at higher levels interact with mitochondria to initiate the intrinsic apoptotic cascade. Intracellular PAF acetylhydrolases specifically hydrolyze truncated phospholipids, and not undamaged, biosynthetic phospholipids, to protect cells from oxidative death. Truncated phospholipids are also formed within cells where they couple cytokine stimulation to mitochondrial damage and apoptosis. The relevance of intracellular truncated phospholipids is shown by the complete protection from cytokine induced apoptosis by PAF acetylhydrolase expression. This protection shows truncated phospholipids are the actual effectors of cytokine mediated toxicity. This article is part of a Special Issue entitled: Oxidized phospholipids-their properties and interactions with proteins.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2012 Oct;1818(10):2456-64. Epub 2012 Mar 16.
  • This report reviews structurally related phospholipid oxidation products that are biologically active where molecular mechanisms have been defined. Phospholipids containing polyunsaturated fatty acyl residues are chemically or enzymatically oxidized to phospholipid hydroperoxides, which may fragment
  • PMID 22445850
  • Modulation of oxidative stress, inflammation, and atherosclerosis by lipoprotein-associated phospholipase A2.
  • Rosenson RS, Stafforini DM.SourceMount Sinai School of Medicine, New York, NY 10029; and.
  • Journal of lipid research.J Lipid Res.2012 Sep;53(9):1767-82. Epub 2012 Jun 4.
  • Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), also known as platelet-activating factor acetylhydrolase (PAF-AH), is a unique member of the phospholipase A(2) superfamily. This enzyme is characterized by its ability to specifically hydrolyze PAF as well as glycerophospholipids containing sho
  • PMID 22665167

和文文献

  • Pitavastatin Increases HDL Particles Functionally Preserved with Cholesterol Efflux Capacity and Antioxidative Actions in Dyslipidemic Patients
  • , , , , , , ,
  • Journal of Atherosclerosis and Thrombosis 20(9), 708-716, 2013
  • … The cholesterol efflux capacity and activities of the antioxidative enzymes paraoxonase-1 (PON-1) and platelet-activating factor acetylhydrolase (PAF-AH) were evaluated using polyethethylene glycol-treated HDL fractions before and after pitavastatin treatment.Results: Pitavastatin treatment decreased the serum LDL-C level by 39% and increased the serum HDL-C level by 9% (p<0.05). …
  • NAID 130004845448
  • Lp-PLA2 (PAF acetylhydrolase) (今月の主題 広義のアポリポ蛋白) -- (臨床検査への応用の可能性)
  • 今泉 忠淳,吉田 秀見,松宮 朋穂 [他]
  • 臨床検査 54(4), 389-393, 2010-04
  • NAID 40017066108
  • 血漿PAF-AH欠損症 (特集 脳卒中と遺伝子)

関連リンク

platelet-activating factor(PAF)は刺激を受けた様々な細胞で合成される生理活性を有したリン脂質です。PAFは,細胞および血漿中に存在し,PAF-AH(PAF acetylhydrolase)によって不活性lyso-PAFになります。血漿PAF-AHは,sn-2 ...
Original Article from The New England Journal of Medicine — Platelet-Activating Factor, PAF Acetylhydrolase, and Severe Anaphylaxis ... Results Mean (±SD) serum PAF levels were significantly higher in patients with ...

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★リンクテーブル★
リンク元PAFアセチルヒドロラーゼ」「Lp-PLA2」「1-alkyl-2-acetylglycerophosphocholine esterase」「lipoprotein-associated phospholipase A2」「血小板活性化因子アセチルヒドロラーゼ
関連記事PA」「P」「PAF」「acetylhydrolase

PAFアセチルヒドロラーゼ」

  [★]

PAF acetylhydrolase
血小板活性化因子アセチルヒドロラーゼ1-アルキル-2-アセチルグリセロホスホコリンエステラーゼ、リ・タンパク質関連ホスホリパーゼA2


Lp-PLA2」

  [★]

  • リ・タンパク質関連ホスホリパーゼA2
1-alkyl-2-acetylglycerophosphocholine esteraselipoprotein-associated phospholipase A2PAF acetylhydrolase


1-alkyl-2-acetylglycerophosphocholine esterase」

  [★]

1-アルキル-2-アセチルグリセロホスホコリンエステラーゼ

lipoprotein-associated phospholipase A2Lp-PLA2PAF acetylhydrolase


lipoprotein-associated phospholipase A2」

  [★]

リポタンパク質関連ホスホリパーゼA2

1-alkyl-2-acetylglycerophosphocholine esteraseLp-PLA2PAF acetylhydrolase


血小板活性化因子アセチルヒドロラーゼ」

  [★]

platelet-activating factor acetylhydrolasePAF acetylhydrolase
PAFアセチルヒドロラーゼ


PA」

  [★]


PrepTutorEJDIC   license prepejdic

「personal assistant個人秘書 / public address [system]」


P」

  [★]


WordNet   license wordnet

「the 16th letter of the Roman alphabet」
p

PrepTutorEJDIC   license prepejdic

「parking」

PrepTutorEJDIC   license prepejdic

「phosphorusの化学記号」


PAF」

  [★] 血小板活性化因子, platelet activating factor, platelet-activating factor


acetylhydrolase」

  [★]

アセチルヒドロラーゼ




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