関: cadherin、E-cadherin、N-cadherin、uvomorulin

WordNet

the 16th letter of the Roman alphabet (同)p
a river in western Thailand; a major tributary of the Chao Phraya (同)Ping River

PrepTutorEJDIC

parking
phosphorusの化学記号
palladiumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/13 03:05:40」(JST)

wiki en

[Wiki en表示]

Cadherin-3, also known as P-Cadherin, is a protein that in humans is encoded by the CDH3 gene.^[1]^[2]

Function

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas.

Clinical significance

Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.^[2]

Interactions

CDH3 (gene) has been shown to interact with:

Beta-catenin,^[3]^[4]
CDH1,^[3]
Catenin (cadherin-associated protein), alpha 1,^[3]^[4]
Nephrin^[5] and
Plakoglobin.^[3]

References

^ Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (Oct 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864.
^ ^a ^b "Entrez Gene: CDH3 cadherin 3, type 1, P-cadherin (placental)".
^ ^a ^b ^c ^d Klingelhöfer J, Troyanovsky RB, Laur OY, Troyanovsky S (Aug 2000). "Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions". Journal of Cell Science. 113 ( Pt 16): 2829–36. PMID 10910767.
^ ^a ^b Schmeiser K, Grand RJ (Apr 1999). "The fate of E- and P-cadherin during the early stages of apoptosis". Cell Death and Differentiation 6 (4): 377–86. doi:10.1038/sj.cdd.4400504. PMID 10381631.
^ Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG (Sep 2004). "Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". The American Journal of Pathology 165 (3): 923–36. doi:10.1016/S0002-9440(10)63354-8. PMC 1618613. PMID 15331416.

External links

CDH3 human gene location in the UCSC Genome Browser.
CDH3 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 遺伝性のびまん性胃癌 hereditary diffuse gastric cancer
2. 遺伝性びまん性胃癌に対する外科的マネージメント surgical management of hereditary diffuse gastric cancer
3. 乳癌の病理 pathology of breast cancer
4. 頭頸部の扁平上皮癌化：分子学的および遺伝学的変化 head and neck squamous cell carcinogenesis molecular and genetic alterations
5. 前立腺癌の分子生物学 molecular biology of prostate cancer

English Journal

Sulindac modulates secreted protein expression from LIM1215 colon carcinoma cells prior to apoptosis.

Greening DW, Ji H, Kapp EA, Simpson RJ.SourceLa Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, Victoria, Australia.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Nov;1834(11):2293-307. doi: 10.1016/j.bbapap.2013.07.007. Epub 2013 Jul 27.
Colorectal cancer (CRC) is a major cause of mortality in Western populations. Growing evidence from human and rodent studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) cause regression of existing colon tumors and act as effective chemopreventive agents in sporadic colon tumor forma
PMID 23899461

Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins.

Vester-Christensen MB, Halim A, Joshi HJ, Steentoft C, Bennett EP, Levery SB, Vakhrushev SY, Clausen H.SourceCopenhagen Center for Glycomics and Department of Cellular and Molecular Medicine and School of Dentistry, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2013 Oct 7. [Epub ahead of print]
The metazoan O-mannose (O-Man) glycoproteome is largely unknown. It has been shown that up to 30% of brain O-glycans are of the O-Man type, but essentially only alpha-dystroglycan (α-DG) of the dystrophin-glycoprotein complex is well characterized as an O-Man glycoprotein. Defects in O-Man glycosyl
PMID 24101494

N-cadherin Expression in Feline Mammary Tumors Is Associated With a Reduced E-cadherin Expression and the Presence of Regional Metastasis.

Buendia AJ, Peñafiel-Verdu C, Navarro JA, Vilafranca M, Sanchez J.SourceFacultad de Veterinaria, Universidad de Murcia, Murcia, Spain.
Veterinary pathology.Vet Pathol.2013 Oct 3. [Epub ahead of print]
The cadherin family of adhesion molecules regulates cell-cell interactions. N-cadherin is expressed by neural and fibroblast cells but not by normal epithelial cells. In human medicine, the role of N-cadherin in breast cancer remains controversial, but some studies have described the switch from E-c
PMID 24091815

Japanese Journal

Expression of Podoplanin and Classical Cadherins in Salivary Gland Epithelial Cells of Klotho-Deficient Mice

Amano Ikuko,Imaizumi Yuri,Kaji Chiaki,Kojima Hiroshi,Sawa Yoshihiko
ACTA HISTOCHEMICA ET CYTOCHEMICA 44(6), 267-276, 2011
… Although aging resulted in growth suppression of myoepithelial cells because of the sparse distribution of the cells in kl/kl mouse salivary glands, the expression of podoplanin and E-cadherin was shown in aging myoepithelial cells. … It is thought that podoplanin participates in the actin-E-cadherin networks which are maintained in aging myoepithelial cells. …
NAID 130001258484

Kinetics of p120-catenin in a human gingival cancer cell line treated with ZD1839

Tamura Isao,Wato Masahiro,Kamada Aiko,Goda Seiji,Yoshikawa Yoshihiro,Domae Eisuke,Tanaka Akio,Ikeo Takashi
Journal of Osaka Dental University 44(2), 169-175, 2010-10-00
… p120-catenin (p120) is a very critical element in the cadherin/catenin cell-cell adhesion complex. … We previously reported that phosphorylated β-catenin disrupts the regulation of E- and P-cadherin stability and adherens junction formation in cancer tissues. …
NAID 110007811667

High-grade neuroendocrine carcinoma of the lung : Comparative clinicopathological study of large cell neuroendocrine carcinoma and small cell lung carcinoma

SUN Lihua,SAKURAI Shinji,SANO Takaaki,HIRONAKA Mitsugu,KAWASHIMA Osamu,NAKAJIMA Takashi
Pathology international 59(8), 522-529, 2009-08-01
NAID 10027381029

Related Pictures

★リンクテーブル★

リンク元	「P-カドヘリン」「E-cadherin」「uvomorulin」「N-cadherin」「Pカドヘリン」
関連記事	「P」「p」「Pd」

「P-カドヘリン」

Cadherin 3, type 1, P-cadherin (placental)
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	4OY9
Identifiers
Symbols	CDH3 ; CDHP; HJMD; PCAD
External IDs	OMIM: 114021 MGI: 88356 HomoloGene: 20425 GeneCards: CDH3 Gene
Gene ontology
Molecular function	• molecular_function; • calcium ion binding;
Cellular component	• cytoplasm; • plasma membrane; • cell-cell adherens junction; • integral component of membrane;
Biological process	• retina homeostasis; • cell adhesion; • homophilic cell adhesion via plasma membrane adhesion molecules; • visual perception; • positive regulation of gene expression; • positive regulation of keratinocyte proliferation; • single organismal cell-cell adhesion; • hair cycle process; • keratinization; • positive regulation of monophenol monooxygenase activity; • negative regulation of transforming growth factor beta2 production; • cell junction assembly; • adherens junction organization; • wound healing; • response to drug; • positive regulation of insulin-like growth factor receptor signaling pathway; • cell-cell junction organization; • positive regulation of melanin biosynthetic process; • negative regulation of catagen; • canonical Wnt signaling pathway; • regulation of hair cycle by canonical Wnt signaling pathway; • positive regulation of melanosome transport;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;