WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

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A delicate interplay of structure, dynamics, and thermodynamics for function: a high pressure NMR study of outer surface protein A.

Kitahara R, Simorellis AK, Hata K, Maeno A, Yokoyama S, Koide S, Akasaka K.SourceCollege of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan.
Biophysical journal.Biophys J.2012 Feb 22;102(4):916-26. doi: 10.1016/j.bpj.2011.12.010. Epub 2012 Feb 21.
Outer surface protein A (OspA) is a crucial protein in the infection of Borrelia burgdorferi causing Lyme disease. We studied conformational fluctuations of OspA with high-pressure (15)N/(1)H two-dimensional NMR along with high-pressure fluorescence spectroscopy. We found evidence within folded, nat
PMID 22385863

Development of a multiplex assay for the detection of antibodies to Borrelia burgdorferi in horses and its validation using Bayesian and conventional statistical methods.

Wagner B, Freer H, Rollins A, Erb HN, Lu Z, Gröhn Y.SourceDepartment of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY, USA. bw73@cornell.edu
Veterinary immunology and immunopathology.Vet Immunol Immunopathol.2011 Dec 15;144(3-4):374-81. doi: 10.1016/j.vetimm.2011.08.005. Epub 2011 Aug 17.
Lyme disease is a zoonotic, vector-borne disease and occurs in mammals including horses. The disease is induced by infection with spirochetes of the Borrelia burgdorferi sensu lato group. Infection of mammalian hosts requires transmission of spirochetes by infected ticks during tick bites. Lyme dise
PMID 21890217

Probing the Borrelia burgdorferi surface lipoprotein secretion pathway using a conditionally folding protein domain.

Chen S, Zückert WR.SourceDepartment of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
Journal of bacteriology.J Bacteriol.2011 Dec;193(23):6724-32. doi: 10.1128/JB.06042-11. Epub 2011 Sep 30.
Surface lipoproteins of Borrelia spirochetes are important virulence determinants in the transmission and pathogenesis of Lyme disease and relapsing fever. To further define the conformational secretion requirements and to identify potential lipoprotein translocation intermediates associated with th
PMID 21965569

Consensus Sequence on the Genes Encoding the Major Outer Surface Proteins(OspA and OspB)of Borrelia garinii Isolate

Negative Finding in Cross-Protective Activity of Japanese Borrelia Isolates against Infection with Three Species of Lyme Disease Borrelia in Outbred Mice

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MICROBIOLOGY and IMMUNOLOGY 41(9), 733-736, 1997
… Outer surface protein A (OspA) is the most promising candidate for a component vaccine against Lyme disease caused by Borrelia burgdorferi sensu lato. … Active cross-protection using a whole-cell vaccine prepared from strains belonging various OspA serotypes observed in Japan and worldwide was examined. … No cross-protection was obtained by heterologous OspA-serotype vaccines. …
NAID 130003484553