同: organic cation transporters

English Journal

Interactions of the active components of Punica granatum (pomegranate) with the essential renal and hepatic human Solute Carrier transporters.

Li Z1, Wang K, Zheng J, Cheung FS, Chan T, Zhu L, Zhou F.
Pharmaceutical biology.Pharm Biol.2014 Dec;52(12):1510-7. doi: 10.3109/13880209.2014.900809. Epub 2014 Jul 15.
Abstract Context: Solute carrier transporters (SLCs) are membrane proteins responsible for cellular influx of various substances including many pharmaceutical agents; therefore, they largely impact on drug disposition and elimination in body. Punica granatum Linnaeus (Lythraceae), pomegranate, is a
PMID 25026340

Involvement of the H+/organic Cation Antiporter in Nicotine Transport in Rat Liver.

Tega Y1, Akanuma SI1, Kubo Y1, Hosoya KI2.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2014 Oct 28. pii: dmd.114.061002. [Epub ahead of print]
Nicotine is an addictive alkaloid in cigarette smoke and is responsible for tobacco dependence. It is important to consider the blood-to-liver transport of nicotine in order to understand the nicotine elimination from the body since most of the nicotine is converted to inactive metabolites by cytoch
PMID 25352656

Renal handling of amphotericin B and amphotericin B-deoxycholate and potential renal drug-drug interactions with selected antivirals.

Trejtnar F1, Mandíková J2, Kočíncová J2, Volková M2.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2014 Oct;58(10):5650-7. doi: 10.1128/AAC.02829-14. Epub 2014 Jun 23.
Amphotericin B (AmB) is excreted via the renal excretion route. This excretion process may result in nephrotoxicity. However, relevant information on the precise renal excretion mechanisms is not available. The aim of the study was to analyze the possible interaction of AmB or its prodrug AmB deoxyc
PMID 24957831

Japanese Journal

Evidence for organic cation transporter-mediated metformin transport and 5'-adenosine monophosphate-activated protein kinase activation in rat skeletal muscles.

Oshima Rieko,Yamada Mayumi,Kurogi Eriko,Ogino Yohei,Serizawa Yasuhiro,Tsuda Satoshi,Ma Xiao,Egawa Tatsuro,Hayashi Tatsuya
Metabolism 64(2), 296-304, 2015-02
… We investigated whether metformin (MET) acts directly on skeletal muscle, is transported into skeletal muscle via organic cation transporters (OCTs), and activates AMPK. … [Conclusion] These results suggest that MET is acutely transported into skeletal muscle by OCTs, and stimulates AMPKα1 and α2 activity in both fast- and slow-twitch muscle types, at least in part by reducing the energy state. …
NAID 120005540403

『安全な薬物療法と効率的な医薬品開発に向けて』　薬物トランスポーターと相互作用

小森久和,玉井郁巳
日本薬理学雑誌 143(5), 243-248, 2014
… 影響する．そのため現在，輸送体上でのDDIについて医薬品の開発段階におけるガイドラインが出され，DDIによる副作用の回避に向けた対応が進んでいる．ガイドライン上で対象となる薬物輸送体はOATPs，OATs，OCTs，P-糖タンパク質，およびBCRPであるが，これらは多様な医薬品の体内動態に関わるため重要視されている．さらに，MATEs，MRPs，BSEPなども重篤な副作用の原因となる可能性が懸念されている．DDIのメカニズム解 …
NAID 130004827696

Proton-Coupled Organic Cation Antiporter-Mediated Uptake of Apomorphine Enantiomers in Human Brain Capillary Endothelial Cell Line hCMEC/D3

Okura Takashi,Higuchi Kei,Kitamura Atsushi [他],Deguchi Yoshiharu
Biological and Pharmaceutical Bulletin 37(2), 286-291, 2014
… The C/M ratio was significantly decreased by amantadine, verapamil, pyrilamine and diphenhydramine (substrates or inhibitors of proton-coupled organic cation antiporter), while tetraethylammonium (substrate of organic cation transporters (OCTs)) and carnitine (substrate of carnitine/organic cation transporter 2; …
NAID 130003382121

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