- 関
- organic cation transporter 1
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/03 19:26:00」(JST)
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| POU class 2 homeobox 1 |
PDB rendering based on 1cqt. |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
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1CQT, 1E3O, 1GT0, 1HF0, 1O4X, 1OCT, 1POG, 1POU
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| Identifiers |
| Symbols |
POU2F1 ; OCT1; OTF1; oct-1B |
| External IDs |
OMIM: 164175 MGI: 101898 HomoloGene: 37658 GeneCards: POU2F1 Gene |
| Gene ontology |
| Molecular function |
• sequence-specific DNA binding transcription factor activity
• protein binding
• sequence-specific DNA binding
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| Cellular component |
• nucleus
• nucleoplasm
• nucleolus
• cytoplasm
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| Biological process |
• transcription from RNA polymerase III promoter
• gene expression
• negative regulation of transcription, DNA-templated
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| Sources: Amigo / QuickGO |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
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| Entrez |
5451 |
18986 |
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| Ensembl |
ENSG00000143190 |
ENSMUSG00000026565 |
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| UniProt |
P14859 |
P25425 |
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| RefSeq (mRNA) |
NM_001198783 |
NM_011137 |
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| RefSeq (protein) |
NP_001185712 |
NP_035267 |
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| Location (UCSC) |
Chr 1:
167.19 – 167.4 Mb |
Chr 1:
165.87 – 166 Mb |
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| PubMed search |
[1] |
[2] |
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POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.[1][2]
Contents
- 1 Interactions
- 2 See also
- 3 References
- 4 Further reading
- 5 External links
Interactions
POU2F1 has been shown to interact with:
- EPRS,[3]
- Glucocorticoid receptor,[4][5][6]
- Glyceraldehyde 3-phosphate dehydrogenase,[7]
- Host cell factor C1,[8][9]
- Ku80,[10][11]
- MNAT1[12]
- NPAT,[7]
- Nuclear receptor co-repressor 2,[13]
- POU2AF1,[14][15][16]
- RELA,[17]
- Retinoid X receptor alpha,[4][18]
- SNAPC4,[19][14]
- Sp1 transcription factor,[20][21] and
- TATA binding protein.[22]
See also
- Octamer transcription factor
References
- ^ Roberts SB, Segil N, Heintz N (October 1991). "Differential phosphorylation of the transcription factor Oct1 during the cell cycle". Science 253 (5023): 1022–6. doi:10.1126/science.1887216. PMID 1887216.
- ^ "Entrez Gene: POU2F1 POU domain, class 2, transcription factor 1".
- ^ Nie J, Sakamoto S, Song D, Qu Z, Ota K, Taniguchi T (March 1998). "Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase". FEBS Lett. 424 (1-2): 27–32. doi:10.1016/s0014-5793(98)00131-8. PMID 9537509.
- ^ a b Préfontaine GG, Walther R, Giffin W, Lemieux ME, Pope L, Haché RJ (September 1999). "Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter". J. Biol. Chem. 274 (38): 26713–9. doi:10.1074/jbc.274.38.26713. PMID 10480874.
- ^ Wang JM, Préfontaine GG, Lemieux ME, Pope L, Akimenko MA, Haché RJ (October 1999). "Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding". Mol. Cell. Biol. 19 (10): 7106–22. PMC 84705. PMID 10490647.
- ^ Préfontaine GG, Lemieux ME, Giffin W, Schild-Poulter C, Pope L, LaCasse E et al. (June 1998). "Recruitment of octamer transcription factors to DNA by glucocorticoid receptor". Mol. Cell. Biol. 18 (6): 3416–30. PMC 108923. PMID 9584182.
- ^ a b McKnight S (July 2003). "Gene switching by metabolic enzymes--how did you get on the invitation list?". Cell 114 (2): 150–2. doi:10.1016/s0092-8674(03)00563-4. PMID 12887915.
- ^ La Boissière S, Hughes T, O'Hare P (January 1999). "HCF-dependent nuclear import of VP16". EMBO J. 18 (2): 480–9. doi:10.1093/emboj/18.2.480. PMC 1171141. PMID 9889203.
- ^ Kristie TM, Sharp PA (March 1993). "Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)". J. Biol. Chem. 268 (9): 6525–34. PMID 8454622.
- ^ Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M et al. (May 2001). "The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase". J. Biol. Chem. 276 (20): 16848–56. doi:10.1074/jbc.M100768200. PMID 11279128.
- ^ Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M (October 2002). "Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication". Biochim. Biophys. Acta 1578 (1-3): 59–72. doi:10.1016/s0167-4781(02)00497-9. PMID 12393188.
- ^ Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG (November 1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors". J. Biol. Chem. 272 (47): 29852–8. doi:10.1074/jbc.272.47.29852. PMID 9368058.
- ^ Kakizawa T, Miyamoto T, Ichikawa K, Takeda T, Suzuki S, Mori J et al. (March 2001). "Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor". J. Biol. Chem. 276 (13): 9720–5. doi:10.1074/jbc.M008531200. PMID 11134019.
- ^ a b Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P et al. (January 1998). "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1". Mol. Cell. Biol. 18 (1): 368–77. PMC 121507. PMID 9418884.
- ^ Chasman D, Cepek K, Sharp PA, Pabo CO (October 1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. PMC 317104. PMID 10541551.
- ^ Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J et al. (June 2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry 40 (22): 6580–8. doi:10.1021/bi010095x. PMID 11380252.
- ^ van Heel DA, Udalova IA, De Silva AP, McGovern DP, Kinouchi Y, Hull J et al. (May 2002). "Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors". Hum. Mol. Genet. 11 (11): 1281–9. doi:10.1093/hmg/11.11.1281. PMID 12019209.
- ^ Kakizawa T, Miyamoto T, Ichikawa K, Kaneko A, Suzuki S, Hara M et al. (July 1999). "Functional interaction between Oct-1 and retinoid X receptor". J. Biol. Chem. 274 (27): 19103–8. doi:10.1074/jbc.274.27.19103. PMID 10383413.
- ^ Hovde S, Brooks A, Strong K, Geiger JH (March 2002). "Crystallization of the Oct-1/SNAP190 peptide/DNA complex". Acta Crystallogr. D Biol. Crystallogr. 58 (Pt 3): 511–2. doi:10.1107/s0907444901021461. PMID 11856838.
- ^ Ström AC, Forsberg M, Lillhager P, Westin G (June 1996). "The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression". Nucleic Acids Res. 24 (11): 1981–6. doi:10.1093/nar/24.11.1981. PMC 145891. PMID 8668525.
- ^ Gunther M, Laithier M, Brison O (July 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol. Cell. Biochem. 210 (1-2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766.
- ^ Zwilling S, Annweiler A, Wirth T (May 1994). "The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP". Nucleic Acids Res. 22 (9): 1655–62. doi:10.1093/nar/22.9.1655. PMC 308045. PMID 8202368.
Further reading
- Hsieh CL, Sturm R, Herr W, Francke U (1990). "The gene for the ubiquitous octamer-binding protein October–1 is on human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on mouse chromosome 1". Genomics 6 (4): 666–72. doi:10.1016/0888-7543(90)90502-L. PMID 2341156.
- Sturm RA, Das G, Herr W (1989). "The ubiquitous octamer-binding protein October–1 contains a POU domain with a homeo box subdomain". Genes Dev. 2 (12A): 1582–99. doi:10.1101/gad.2.12a.1582. PMID 2905684.
- Nakshatri H, Nakshatri P, Currie RA (1995). "Interaction of October–1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter". J. Biol. Chem. 270 (33): 19613–23. doi:10.1074/jbc.270.33.19613. PMID 7642649.
- Cox M, van Tilborg PJ, de Laat W, Boelens R, van Leeuwen HC, van der Vliet PC et al. (1995). "Solution structure of the October–1 POU homeodomain determined by NMR and restrained molecular dynamics". J. Biomol. NMR 6 (1): 23–32. doi:10.1007/BF00417488. PMID 7663141.
- Jeang KT, Chun R, Lin NH, Gatignol A, Glabe CG, Fan H (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". J. Virol. 67 (10): 6224–33. PMC 238044. PMID 7690421.
- Zwilling S, König H, Wirth T (1995). "High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors". EMBO J. 14 (6): 1198–208. PMC 398197. PMID 7720710.
- Sturm RA, Eyre HJ, Baker E, Sutherland GR (1995). "The human OTF1 locus which overlaps the CD3Z gene is located at 1q22→q23". Cytogenet. Cell Genet. 68 (3–4): 231–2. doi:10.1159/000133919. PMID 7842742.
- Klemm JD, Rould MA, Aurora R, Herr W, Pabo CO (1994). "Crystal structure of the October–1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules". Cell 77 (1): 21–32. doi:10.1016/0092-8674(94)90231-3. PMID 8156594.
- Zwilling S, Annweiler A, Wirth T (1994). "The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP". Nucleic Acids Res. 22 (9): 1655–62. doi:10.1093/nar/22.9.1655. PMC 308045. PMID 8202368.
- Kristie TM, Sharp PA (1993). "Purification of the cellular C1 factor required for the stable recognition of the October–1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)". J. Biol. Chem. 268 (9): 6525–34. PMID 8454622.
- Assa-Munt N, Mortishire-Smith RJ, Aurora R, Herr W, Wright PE (1993). "The solution structure of the October–1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain". Cell 73 (1): 193–205. doi:10.1016/0092-8674(93)90171-L. PMID 8462099.
- Dekker N, Cox M, Boelens R, Verrijzer CP, van der Vliet PC, Kaptein R (1993). "Solution structure of the POU-specific DNA-binding domain of October–1". Nature 362 (6423): 852–5. doi:10.1038/362852a0. PMID 8479524.
- Ström AC, Forsberg M, Lillhager P, Westin G (1996). "The transcription factors Sp1 and October–1 interact physically to regulate human U2 snRNA gene expression". Nucleic Acids Res. 24 (11): 1981–6. doi:10.1093/nar/24.11.1981. PMC 145891. PMID 8668525.
- Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG (1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors". J. Biol. Chem. 272 (47): 29852–8. doi:10.1074/jbc.272.47.29852. PMID 9368058.
- Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P et al. (1998). "The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with October–1". Mol. Cell. Biol. 18 (1): 368–77. PMC 121507. PMID 9418884.
- Nie J, Sakamoto S, Song D, Qu Z, Ota K, Taniguchi T (1998). "Interaction of October–1 and automodification domain of poly(ADP-ribose) synthetase". FEBS Lett. 424 (1–2): 27–32. doi:10.1016/S0014-5793(98)00131-8. PMID 9537509.
- Préfontaine GG, Lemieux ME, Giffin W, Schild-Poulter C, Pope L, LaCasse E et al. (1998). "Recruitment of Octamer Transcription Factors to DNA by Glucocorticoid Receptor". Mol. Cell. Biol. 18 (6): 3416–30. PMC 108923. PMID 9584182.
- La Boissière S, Hughes T, O'Hare P (1999). "HCF-dependent nuclear import of VP16". EMBO J. 18 (2): 480–9. doi:10.1093/emboj/18.2.480. PMC 1171141. PMID 9889203.
- Kakizawa T, Miyamoto T, Ichikawa K, Kaneko A, Suzuki S, Hara M et al. (1999). "Functional interaction between October–1 and retinoid X receptor". J. Biol. Chem. 274 (27): 19103–8. doi:10.1074/jbc.274.27.19103. PMID 10383413.
External links
- POU2F1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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PDB gallery
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1cqt: CRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT
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1e3o: CRYSTAL STRUCTURE OF OCT-1 POU DIMER BOUND TO MORE
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1gt0: CRYSTAL STRUCTURE OF A POU/HMG/DNA TERNARY COMPLEX
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1hf0: CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF OCT-1 BOUND TO DNA AS A DIMER
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1o4x: TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
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1oct: CRYSTAL STRUCTURE OF THE OCT-1 POU DOMAIN BOUND TO AN OCTAMER SITE: DNA RECOGNITION WITH TETHERED DNA-BINDING MODULES
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1pog: SOLUTION STRUCTURE OF THE OCT-1 POU-HOMEO DOMAIN DETERMINED BY NMR AND RESTRAINED MOLECULAR DYNAMICS
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1pou: THE SOLUTION STRUCTURE OF THE OCT-1 POU-SPECIFIC DOMAIN REVEALS A STRIKING SIMILARITY TO THE BACTERIOPHAGE LAMBDA REPRESSOR DNA-BINDING DOMAIN
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UpToDate Contents
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English Journal
- A common novel splice variant of SLC22A1 (OCT1) is associated with impaired responses to imatinib in patients with chronic myeloid leukaemia.
- Grinfeld J, Gerrard G, Alikian M, Alonso-Dominguez J, Ale S, Valgañon M, Nteliopoulos G, White D, Marin D, Hedgley C, O'Brien S, Clark R, Goldman JM, Milojkovic D, Apperley JF, Foroni L.SourceDepartment of Haematology, Imperial College Healthcare NHS Trust, London, UK.
- British journal of haematology.Br J Haematol.2013 Dec;163(5):631-9. doi: 10.1111/bjh.12591. Epub 2013 Oct 10.
- Approximately one-third of patients with chronic myeloid leukaemia will fail to achieve or maintain responses to imatinib. Changes in solute carrier family 22 (organic cation transporter), member 1 (SLC22A1, also termed OCT1), the main transporter for imatinib, have been proposed as a possible predi
- PMID 24117365
- Genetically modified mouse models for oral drug absorption and disposition.
- Tang SC, Hendrikx JJ, Beijnen JH, Schinkel AH.SourceDivision of Molecular Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
- Current opinion in pharmacology.Curr Opin Pharmacol.2013 Dec;13(6):853-8. doi: 10.1016/j.coph.2013.08.011. Epub 2013 Sep 8.
- Intestinal absorption is an essential step in the therapeutic use of most orally administered drugs and often mediated by enterocyte transmembrane transporters. Here we discuss several of these drug transport systems and knockout mouse models to study them. These studies showed that Multidrug resist
- PMID 24021267
- Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy.
- Lee N, Hebert MF, Prasad B, Easterling TR, Kelly EJ, Unadkat JD, Wang J.SourceDepartments of Pharmaceutics (N.L., B.P., E.J.K., J.D.U., J.W.), Pharmacy (M.F.H., T.R.E.), and Obstetrics and Gynecology (M.F.H., T.R.E.), and the Obstetric-Fetal Pharmacology Research Unit (N.L., M.F.H., T.R.E., J.W.), University of Washington, Seattle, Washington.
- Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2013 Dec;41(12):2225-32. doi: 10.1124/dmd.113.054072. Epub 2013 Oct 7.
- Polyspecific organic cation (OC) transporters play important roles in the disposition of clinically used drugs, including drugs used during pregnancy. Pregnancy is known to alter the expression of drug-metabolizing enzymes and transporters, but its specific effect on OC transporters has not been wel
- PMID 24101703
Japanese Journal
- Distinct Interaction of Nilotinib and Imatinib with P-Glycoprotein in Intracellular Accumulation and Cytotoxicity in CML Cell Line K562 Cells
- Yamakawa Yuji,Hamada Akinobu,Uchida Takashi,Sato Daisuke,Yuki Misato,Hayashi Masahiro,Kawaguchi Tatsuya,Saito Hideyuki
- Biological and Pharmaceutical Bulletin 37(8), 1330-1335, 2014
- … Inhibition experiments in K562 cells, and examination of the cellular uptake using influx transporter-transfected human embryonic kidney (HEK) 293 cells, suggested that the influx transporters OCT1 and OATP1A2, which have been reported to mediate accumulation of imatinib in CML cells, contributed little to the uptake of nilotinib. …
- NAID 130004677542
- 奥平 典子
- 日本毒性学会学術年会 40.1(0), 1022, 2013
- … 評価の対象とされたトランスポーターは，FDAではP-gp/BCRP, OATP1B1, 1B3, OCT2, OAT1, OAT3の7種，EMAではこれに加えてBSEP, MATE,OCT1が考慮するべきトランスポーターとして挙げられている。 …
- NAID 130004676556
- Inter-individual Variability in OCT1 Expression and Its Relationship with OCT1 Genotype in Liver Samples from a Korean Population
- KIM Min-Hye,SHIN Ho Jung,LIM Su Jeong,PARK Jung-Soon,LEE Sang-Seop,SONG Im-Sook,SHIN Jae-Gook
- Drug Metabolism and Pharmacokinetics 27(5), 530-535, 2012
- … To clarify inter-individual variation in the expression of organic cation transporter 1 (OCT1), the levels of OCT1 mRNA and protein from 65 human liver samples were examined by real-time PCR and Western blot analysis and were associated with OCT1 genotypes. … The expression levels of OCT1 mRNA and protein in 65 liver samples of Korean origin were not normally distributed and varied by 23.6- and 15.9-fold, respectively. …
- NAID 130004463275
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Related Pictures
★リンクテーブル★
[★]
- 英
- organic cation transporter 1、OCT1
- 関
- 有機カチオントランス・ーター1
[★]
有機カチオン輸送体1、有機カチオントランス・ーター1
- 関
- OCT1
[★]
- 英
- organic cation transporter 1、OCT1
- 関
- 有機カチオン輸送体1
[★]
[★]