English Journal

Naud J, Laurin LP, Michaud J, Beauchemin S, Leblond FA, Pichette V.Source1 Centre de recherche de l'hopital Maisonneuve-Rosemont;
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2011 Oct 3. [Epub ahead of print]
Studies demonstrated that chronic renal failure (CRF) affects the expression and activity of intestinal, hepatic and renal drug transporters. Such drug transporters are expressed in brain cells and at the blood-brain-barrier (BBB) where they limit the entry and distribution of drugs in the brain. Pe
PMID 21969519

Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK via PKC{alpha}-mediated MKP-1 induction.

Kim SY, Kwon YW, Jung IL, Sung JH, Park SG.SourceDepartment of Biomedical Science, CHA University, 606-16, Yeoksamdong, Kangnamgu, Seoul 135-081, Republic of Korea.
Cardiovascular research.Cardiovasc Res.2011 Sep 7. [Epub ahead of print]
AIMS: Hyperplasia of vascular smooth muscle cells (VSMCs) after blood vessel injury is one of the major pathophysiological mechanisms associated with neointima. Tauroursodeoxycholate (TUDCA) is a cytoprotective agent in a variety of cells including hepatocytes as well as an inducer of apoptosis in c
PMID 21840882

Japanese Journal

Tamai Ikumi
Advanced Drug Delivery Reviews 64(6), 508-514, 2012-05-01
… Recently, organic anion transporting polypeptide (OATP) family such as OATP1A2 and OATP2B1 has been suggested to mediate intestinal absorption of several drugs. … Recent pharmacogenomic studies demonstrated that OATP2B1 is involved in the drug absorption in human. … In addition, information of drug-juice interaction in the intestine also uncovered the contribution of OATP1A2 and OATP2B1 in drug absorption. …
NAID 120003386985

小林靖奈,野島淳子,大林真幸 [他],神山紀子,山元俊憲
薬学雑誌 131(10), 1493-1501, 2011
… Although there are several PG transporters such as multidrug resistance-associated protein 4 (MRP4), organic cation transporter 1 (OCT1) [solute carrier (SLC) 22A1], organic anion transporter 1-3 (OAT1-3) [SLC22A6-8], OAT4 [SLC11], OATP-1 (LST-1) [SLCO1B1], OATP2B1 [SLCO2B1], OATP2A1 (PGT) [SLCO2A1], OATP4A1 (OATP-E) [SLCO4A1] have been isolated and well characterized, our findings suggest that hPrC functions as a novel transport peptide responsible for PG uptake. …
NAID 130001246170

玉井郁巳
Drug delivery system 25(4), 375-383, 2010-08-06
小腸上皮細胞で栄養物等の吸収に働くトランスポーターは医薬品の吸収性改善に利用できる．多様なトランスポーター分子が栄養成分の摂取に働いているが，なかでもペプチドトランスポーターPEPT1は基質認識性が幅広く，既存の医薬品自体やそのペプチド化プロドラッグ体を認識する．さらに，酸性pHでより高い輸送活性を示すため，通常の弱酸性の小腸管腔内pHでは輸送が弱い場合であっても，酸性ポリマーを用いる製剤的工夫に …
NAID 10026496619