NSAID-induced gastropathy

NSAID胃潰瘍

WordNet

1. reason or establish by induction
2. cause to arise; "induce a crisis" (同)bring_on
3. produce electric current by electrostatic or magnetic processes (同)induct
4. cause to do; cause to act in a specified manner; "The ads induced me to buy a VCR"; "My children finally got me to buy a computer"; "My wife made me buy a new sofa" (同)stimulate, cause, have, get, make
5. cause to occur rapidly; "the infection precipitated a high fever and allergic reactions" (同)stimulate, rush, hasten
6. brought about or caused; not spontaneous; "a case of steroid-induced weakness"

PrepTutorEJDIC

1. 〈人〉‘に'『勧めて』(…)『させる』 / …‘を'『引き起こす』,もたらす(cause) / 〈電気〉‘を'誘導する / …‘を'帰納する
2. National Security Agency(米国の)国家安全保障局

UpToDate Contents

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• 1. 急性出血性のびらん性胃障害および慢性化学性の胃障害 acute hemorrhagic erosive gastropathy and chronic chemical gastropathy
• 2. 慢性疼痛の治療の概要 overview of the treatment of chronic pain
• 3. 成人における上部消化管出血の主要な原因 major causes of upper gastrointestinal bleeding in adults
• 4. 急性痛風の治療 treatment of acute gout
• 5. アスピリン：リウマチ性疾患における作用機序、主な毒性、および使用 aspirin mechanism of action major toxicities and use in rheumatic diseases

English Journal

• A novel model for NSAID induced gastroenteropathy in rats.

• Singh DP1, Borse SP1, Nivsarkar M2.
• Journal of pharmacological and toxicological methods.J Pharmacol Toxicol Methods.2016 Mar-Apr;78:66-75. doi: 10.1016/j.vascn.2015.11.008. Epub 2015 Dec 2.
• INTRODUCTION: Progress in management of Nonsteroidal anti-inflammatory drug (NSAID) induced gastrointestinal toxicity requires the availability of appropriate experimental animal models that are as close to humans as feasible. Our objective was to develop a rat model for NSAID-induced gastroenteropa
• PMID 26655077

• ADMINISTRATION OF H2 BLOCKERS IN NSAID INDUCED GASTROPATHY IN RATS: effect on histopathological changes in gastric, hepatic and renal tissues.

• Manocha S1, Lal D2, Venkataraman S3.
• Arquivos de gastroenterologia.Arq Gastroenterol.2016 Jan-Mar;53(1):36-43. doi: 10.1590/S0004-28032016000100008.
• BACKGROUND: Nonsteroidal anti-inflammatory drugs induces gastric mucosal lesions because of its acidic properties. Ranitidine, an H2 receptor antagonist, has proved beneficial in patients with gastric ulcers.OBJECTIVE: The present study was performed to assess the effect of administering ranitidine
• PMID 27281503

• Network Meta-Analysis Comparing Relatively Selective COX-2 Inhibitors Versus Coxibs for the Prevention of NSAID-Induced Gastrointestinal Injury.

• Yang M1, Wang HT, Zhao M, Meng WB, Ou JQ, He JH, Zou B, Lei PG.
• Medicine.Medicine (Baltimore).2015 Oct;94(40):e1592. doi: 10.1097/MD.0000000000001592.
• Currently 2 difference classes of cyclooxygenase (COX)-2 inhibitors, coxibs and relatively selective COX-2 inhibitors, are available for patients requiring nonsteroidal anti-inflammatory drug (NSAID) therapy; their gastroprotective effect is hardly directly compared. The aim of this study was to com
• PMID 26448006

Japanese Journal

• NSAIDs潰瘍にどう対応するか?

• 潰瘍 = Ulcer research 36(1), 36-39, 2009-05-20
• NAID 10025371525

• Prevention of Indomethacin-Induced Gastric Mucosal Injury in Helicobacter pylori-Negative Healthy Volunteers: A Comparison Study Rebamipide vs Famotidine

• Journal of Clinical Biochemistry and Nutrition 43(1), 34-40, 2008
• NAID 130004466524

• Alteration of Gastric Ulcerogenic and Healing Responses in Rats With Adjuvant-Induced Arthritis

• The Japanese journal of pharmacology 89(1), 1-6, 2002-05-01
• NAID 10008430804

Related Links

• NSAID Gastropathy - Physiopedia, universal access to ...

NSAID induced gastropathy can result from too high of dosage or too frequent intake of NSAID drugs as well as long-term use. These drugs are used to decrease pain and inflammation and are often taken by those diagnosed with ...

• "NSAID-Induced Gastropathy" by Parent, Louise S. - Drug ...

Beginning of article There are currently 17 nonsteroidal anti-inflammatory drugs (NSAIDs) available on the U.S. market, and many more are undergoing studies for possible future approval by the Food & Drug Administration. In 1983 ...

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★リンクテーブル★

リンク元	「NSAID胃潰瘍」
関連記事	「induce」「induced」「NSAID」「NSAIDs」

「NSAID胃潰瘍」

　　[★]

関

胃潰瘍、NSAID-induced gastropathy

• see NSAID or gastric ulcer

リスク因子

• 高齢、潰瘍の既往、糖質ステロイドの併用、高用量あるいは複数のNSAIDの内服、全身疾患の合併 (ガイドライン1)

病態

• 幽門部から前庭部に多発する比較的小さな潰瘍、前庭部の深掘れ潰瘍、不整形の巨大潰瘍などが特徴 (ガイドライン1)

治療と予防

ガイドライン1

• 非ステロイド消炎鎮痛薬(NSAID)は可能ならば中止し通常の潰瘍治療を行う。NSAIDの中止が不可能ならばプロトンポンプ阻害薬(PPI)あるいはプロスタグランジン(PG)製剤により治療を行う。

NSAID継続下での再発の防止には、PPI、PG製剤あるいは高用量のH2受容体拮抗薬(H2RA)が有効である。

• COX-1は胃粘膜などの組織で構成的に発現している。NSAIDの作用によりCOX-1の作用が抑制されると胃潰瘍を来しうる。投与経路(経口、坐薬)を変更してもこの副作用の発現は変わらない、らしい。

ガイドライン

• 1. H19(2007)胃潰瘍GLの適用と評価に関する研究班編／医療・GL(07年)胃潰瘍GLの適用と評価に関する研究班編／医療・GL(07年)

http://minds.jcqhc.or.jp/lo/ps/Fpastlist.aspx

「induce」

　　[★]

• v.

• 誘発する、誘導する、誘起する、導入する、引き起こす

関

cause、challenge、derivation、elicit、elicitation、evocation、evoke、guidance、induction、inductive、introduce、introduction、precipitate、provocation、provoke、spark

　 　 　 　 　 　

「induced」

　　[★]

• v.

• (induceの過去分詞)誘導される、引き起こされる

hypercalcaemia induced pancreatitis 高カルシウム血症による膵炎

　

「NSAID」

　　[★] 非ステロイド性抗炎症薬, non-steroidal antiinflammatory drug

「NSAIDs」

　　[★] 非ステロイド性抗炎症薬