CsA/FK506の作用機序
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NF-AT2→→→NF-A2→|→IL-2産生抑制。T細胞増殖阻害
WordNet
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
- the 14th letter of the Roman alphabet (同)n
PrepTutorEJDIC
- answer / ampere
- nitrogenの化学記号
UpToDate Contents
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English Journal
- Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription, increased nuclear factor of activated T cell activity, and glomerulonephritis.
- Mehta J1, Genin A, Brunner M, Scalzi LV, Mishra N, Beukelman T, Cron RQ.
- Arthritis and rheumatism.Arthritis Rheum.2010 Aug;62(8):2499-509. doi: 10.1002/art.27554.
- OBJECTIVE: To assess CD154 expression in patients with pediatric systemic lupus erythematosus (SLE) and to explore a transcriptional mechanism that may explain dysregulated expression of CD154.METHODS: Cell surface CD154 expression (pre- and postactivation) in peripheral blood CD4 T cells from 29 ch
- PMID 20506525
- Impaired secretion of interleukin-4 and interleukin-13 by allergen-specific T cells correlates with defective nuclear expression of NF-AT2 and jun B: relevance to immunotherapy.
- Faith A1, Richards DF, Verhoef A, Lamb JR, Lee TH, Hawrylowicz CM.
- Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.Clin Exp Allergy.2003 Sep;33(9):1209-15.
- BACKGROUND: Allergen immunotherapy (IT) is a successful treatment associated with decreased Th2 cytokine production by allergen-specific T cells. We have previously demonstrated (Faith et al., J Immunol 1997; 159:53-57) that inhibition of Th2 cytokine production in vitro correlates with impaired tyr
- PMID 12956740
- Expression of nuclear factor of activated T cells mRNA in maternal peripheral blood cells.
- Kojima H1, Tamura T, Okuda T, Kato C, Kinoshita Y, Honjo H.
- American journal of reproductive immunology (New York, N.Y. : 1989).Am J Reprod Immunol.2003 Mar;49(3):139-48.
- PROBLEM: In T lymphocytes, nuclear factor of activated T cells (NF-AT) regulates the induction of cytokine genes upon antigenic stimulation. This study was designed to analyse the relationship between NF-AT and pregnancy.METHOD OF STUDY: With informed consent, peripheral blood cells (PBCs) were obta
- PMID 12797520
Related Links
- Abstract The family of genuine NF-AT transcription factors consists of four members (NF-AT1 [or NF-ATp], NF-AT2 [or NF-ATc], NF-AT3 and NF-AT4 [or NF-ATx]) which are characterized by a highly conserved DNA binding domain (is ...
- 1. Clin Exp Allergy. 2003 Sep;33(9):1209-15. Impaired secretion of interleukin-4 and interleukin-13 by allergen-specific T cells correlates with defective nuclear expression of NF-AT2 and jun B: relevance to immunotherapy. Faith A ...
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神経線維腫症 neurofibromatosis