NF-AT2

出典: meddic

 CsA/FK506の作用機序   カルシニューリンに拮抗する

      CaM       ↓       カルシニューリン       ↓   NF-AT2→→→NF-A2→|→IL-2産生抑制。T細胞増殖阻害

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英文文献

  • Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription, increased nuclear factor of activated T cell activity, and glomerulonephritis.
  • Mehta J1, Genin A, Brunner M, Scalzi LV, Mishra N, Beukelman T, Cron RQ.
  • Arthritis and rheumatism.Arthritis Rheum.2010 Aug;62(8):2499-509. doi: 10.1002/art.27554.
  • OBJECTIVE: To assess CD154 expression in patients with pediatric systemic lupus erythematosus (SLE) and to explore a transcriptional mechanism that may explain dysregulated expression of CD154.METHODS: Cell surface CD154 expression (pre- and postactivation) in peripheral blood CD4 T cells from 29 ch
  • PMID 20506525
  • Impaired secretion of interleukin-4 and interleukin-13 by allergen-specific T cells correlates with defective nuclear expression of NF-AT2 and jun B: relevance to immunotherapy.
  • Faith A1, Richards DF, Verhoef A, Lamb JR, Lee TH, Hawrylowicz CM.
  • Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.Clin Exp Allergy.2003 Sep;33(9):1209-15.
  • BACKGROUND: Allergen immunotherapy (IT) is a successful treatment associated with decreased Th2 cytokine production by allergen-specific T cells. We have previously demonstrated (Faith et al., J Immunol 1997; 159:53-57) that inhibition of Th2 cytokine production in vitro correlates with impaired tyr
  • PMID 12956740
  • Expression of nuclear factor of activated T cells mRNA in maternal peripheral blood cells.
  • Kojima H1, Tamura T, Okuda T, Kato C, Kinoshita Y, Honjo H.
  • American journal of reproductive immunology (New York, N.Y. : 1989).Am J Reprod Immunol.2003 Mar;49(3):139-48.
  • PROBLEM: In T lymphocytes, nuclear factor of activated T cells (NF-AT) regulates the induction of cytokine genes upon antigenic stimulation. This study was designed to analyse the relationship between NF-AT and pregnancy.METHOD OF STUDY: With informed consent, peripheral blood cells (PBCs) were obta
  • PMID 12797520

関連リンク

Abstract The family of genuine NF-AT transcription factors consists of four members (NF-AT1 [or NF-ATp], NF-AT2 [or NF-ATc], NF-AT3 and NF-AT4 [or NF-ATx]) which are characterized by a highly conserved DNA binding domain (is ...
1. Clin Exp Allergy. 2003 Sep;33(9):1209-15. Impaired secretion of interleukin-4 and interleukin-13 by allergen-specific T cells correlates with defective nuclear expression of NF-AT2 and jun B: relevance to immunotherapy. Faith A ...

関連画像

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★リンクテーブル★
関連記事A」「N」「AT」「NF

A」

  [★]

PrepTutorEJDIC   license prepejdic

「answer / ampere」

WordNet   license wordnet

「the 1st letter of the Roman alphabet」
a

WordNet   license wordnet

「the blood group whose red cells carry the A antigen」
type A, group A


N」

  [★]

WordNet   license wordnet

「the 14th letter of the Roman alphabet」
n

PrepTutorEJDIC   license prepejdic

「nitrogenの化学記号」


AT」

  [★]


NF」

  [★] 神経線維腫症 neurofibromatosis


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