WordNet

worry persistently; "nagging concerns and doubts"
bother persistently with trivial complaints; "She nags her husband all day long" (同)peck, hen-peck
remind or urge constantly; "she nagged to take a vacation"
the 14th letter of the Roman alphabet (同)n

PrepTutorEJDIC

おいぼれ馬;駄馬(だば) / 《話》(一般に)馬,(特に)競走馬
(…のことで)〈人〉‘に'がみがみ言う,口やかましく言う《+『名』+『about』+『名』(do『ing』)》;(…をせがんで)…‘に'うるさく言う《+『名』+『for』+『名』》;…‘に'うるさく言って(…)させる《+『名』+『into』+『名』(do『ing』)》 / 〈物事が〉…‘を'しつこく脳ませる / (…に)がみがみ言って苦しめる《+『at』+『名』》 / 〈物事が〉悩みの種になる
nitrogenの化学記号

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1. ヘキソースリン酸側路およびグルタチオン代謝関連疾患 related disorders of the hexose monophosphate shunt and glutathione metabolism
2. 尿素サイクル障害：管理 urea cycle disorders management
3. 尿素サイクル障害：臨床的特徴および診断 urea cycle disorders clinical features and diagnosis
4. 成人における皮膚筋炎および多発性筋炎の臨床症状 clinical manifestations of dermatomyositis and polymyositis in adults
5. 皮膚筋炎および多発性筋炎における間質性肺疾患：臨床症状および診断 interstitial lung disease in dermatomyositis and polymyositis clinical manifestations and diagnosis

Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.

de Cima S1,2, Polo LM1, Díez-Fernández C1,3, Martínez AI3, Cervera J2,3, Fita I4, Rubio V1,2.
Scientific reports.Sci Rep.2015 Nov 23;5:16950. doi: 10.1038/srep16950.
Human carbamoyl phosphate synthetase (CPS1), a 1500-residue multidomain enzyme, catalyzes the first step of ammonia detoxification to urea requiring N-acetyl-L-glutamate (NAG) as essential activator to prevent ammonia/amino acids depletion. Here we present the crystal structures of CPS1 in the absen
PMID 26592762

Shi D1, Allewell NM2, Tuchman M3.
International journal of molecular sciences.Int J Mol Sci.2015 Jun 9;16(6):13004-22. doi: 10.3390/ijms160613004.
N-acetylglutamate synthase (NAGS) catalyzes the production of N-acetylglutamate (NAG) from acetyl-CoA and L-glutamate. In microorganisms and plants, the enzyme functions in the arginine biosynthetic pathway, while in mammals, its major role is to produce the essential co-factor of carbamoyl phosphat
PMID 26068232

The Study of Carbamoyl Phosphate Synthetase 1 Deficiency Sheds Light on the Mechanism for Switching On/Off the Urea Cycle.

Díez-Fernández C1, Gallego J2, Häberle J3, Cervera J4, Rubio V5.
Journal of genetics and genomics = Yi chuan xue bao.J Genet Genomics.2015 May 20;42(5):249-60. doi: 10.1016/j.jgg.2015.03.009. Epub 2015 Apr 1.
Carbamoyl phosphate synthetase 1 (CPS1) deficiency (CPS1D) is an inborn error of the urea cycle having autosomal (2q34) recessive inheritance that can cause hyperammonemia and neonatal death or mental retardation. We analyzed the effects on CPS1 activity, kinetic parameters and enzyme stability of m
PMID 26059772

橋爪清松,戸田千登世,安井照代,永納秀男
衛生化学 38(1), 69-77, 1992-02-29
… TBZ was suspended in olive oil and mice were given, by stomach tube, a single dose of 1300 mg/kg TBZ only (TBZ group), and 350 or 1300 mg/kg TBZ 1 h after intraperitoneal injection of L-buthionine sulfoximine (BSO), an inhibitor of γ-glutamylcysteine synthetase, (BSO-TBZ350 or BSO-TBZ1300 groups). … Blood urea nitrogen (BUN) and enzyme activities such as alkaline phosphatase (ALP), leucine aminopeptidase (LAP), γ-glutamyl transpeptidase (γ-GTP) and N-acetyl-β-D-glucosaminidase (NAG) in the kidney and urine were determined. …
NAID 110003641779

橋爪清松,戸田千登世,安井照代,永納秀男
衛生化学 38(1), 69-77, 1992
… TBZ was suspended in olive oil and mice were given, by stomach tube, a single dose of 1300 mg/kg TBZ only (TBZ group), and 350 or 1300 mg/kg TBZ 1 h after intraperitoneal injection of L-buthionine sulfoximine (BSO), an inhibitor of γ-glutamylcysteine synthetase, (BSO-TBZ350 or BSO-TBZ1300 groups). … Blood urea nitrogen (BUN) and enzyme activities such as alkaline phosphatase (ALP), leucine aminopeptidase (LAP), γ-glutamyl transpeptidase (γ-GTP) and N-acetyl-β-D-glucosaminidase (NAG) in the kidney and urine were determined. …
NAID 130003748485

鈴木道彦
日本腎臓学会誌 33(4), 387-395, 1991
… The urinary activities of N-acetyl-β-D-glucosaminidase (NAG), γ-glutamyl transpeptidase (γ-GTP) and alanine aminopeptidase (AAP) are known to elevate markedly in initial phase of clinical acute renal failure (ARF). … Catheterizated urine was collected to measure changes of the activities of NAG, γ-GTP and AAP from 60 to 480 minutes after reper fusion of the kidney. …
NAID 130004169820