関: NADPH dehydrogenase

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/08 03:30:20」(JST)

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In enzymology, a NADPH dehydrogenase (EC 1.6.99.1) is an enzyme that catalyzes the chemical reaction

NADPH + H⁺ + acceptor NADP⁺ + reduced acceptor

The 3 substrates of this enzyme are NADPH, H⁺, and acceptor, whereas its two products are NADP⁺ and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors. The systematic name of this enzyme class is NADPH:acceptor oxidoreductase. Other names in common use include NADPH2 diaphorase, NADPH diaphorase, OYE, diaphorase, dihydronicotinamide adenine dinucleotide phosphate dehydrogenase, NADPH-dehydrogenase, NADPH-diaphorase, NADPH2-dehydrogenase, old yellow enzyme, reduced nicotinamide adenine dinucleotide phosphate dehydrogenase, TPNH dehydrogenase, TPNH-diaphorase, triphosphopyridine diaphorase, triphosphopyridine nucleotide diaphorase, NADPH2 dehydrogenase, and NADPH:(acceptor) oxidoreductase. It has 2 cofactors: FAD, and FMN.

References

Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 477-494.
AVRON M, JAGENDORF AT (1957). "Some further investigations on chloroplast TPNH diaphorase". Arch. Biochem. Biophys. 72 (1): 17–24. doi:10.1016/0003-9861(57)90169-8. PMID 13471057.
Jagendorf AT (1963). "Chloroplast TPNH diaphorase". Methods Enzymol. 6: 430–434.
Theorell H (1935). "Das gelbe Oxydationsferment". Biochem. Z. 278: 263–290.
Theorell H and Akesson A (1956). "Molecular weight and FMN content of crystalline "old yellow enzyme"". Arch. Biochem. Biophys. 65 (1): 439–448. doi:10.1016/0003-9861(56)90204-1. PMID 13373435.

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Japanese Journal

Localization of eNOS in the Olfactory Epithelium of the Rat

ENDO Daisuke,YAMAMOTO Yoshio,YAMAGUCHI-YAMADA Misuzu,NAKAMUTA Nobuaki,TANIGUCHI Kazuyuki
Journal of Veterinary Medical Science advpub(0), 1010280379, 2010
… The activity of NADPH-diaphorase was also examined as a marker of NOS. In the dorsomedial region of the nasal cavity, intensely positive reactions for NADPH-diaphorase were observed in the entire cytoplasm of sensory cells (olfactory cells). …
NAID 130000444379

Nitric oxide-cGMP signaling regulates axonal elongation during optic nerve regeneration in the goldfish in vitro and in vivo

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Journal of Neurochemistry 110(3), 890-901, 2009-08
… NADPH diaphorase staining revealed that nitric oxide synthase (NOS) activity was up-regulated primarily in the retinal ganglion cells (RGCs) 5-40 days after axotomy. …
NAID 120001450994

「NADPHジアフォラーゼ」

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PMC	articles
PubMed	articles
NCBI	proteins

NADPH dehydrogenase
	; X-ray structure of Xenobiotic Reductase A from Pseudomonas putida. PDB entry 3l5l
Identifiers
EC number	1.6.99.1
CAS number	9001-68-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
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PMC	articles
PubMed	articles
NCBI	proteins

　　[★]

英: NADPH diaphorase
関: NADPHデヒドロゲナーゼ、NADPHジアホラーゼ

「NADPH dehydrogenase」

　　[★]

NADPH脱水素酵素、NADPHデヒドロゲナーゼ

関: NADPH diaphorase

「NADPHジアホラーゼ」

　　[★]

英: NADPH diaphorase
関: NADPHジアフォラーゼ

「NADPH」

　　[★]

関: nicotinamide adenine dinucleotide phosphate

グルタチオンの還元に必要。
足らなくなると、フリーラジカルや過酸化物を無毒化できなくなる。
赤血球の場合でNADPHが足らないと、fava beans, sulfonamides, primaquineおよび抗結核薬などの酸化剤によって溶血性貧血を起こす。

「NAD」

　　[★]

「NADP」

　　[★] ニコチンアミドアデニンジヌクレオチドリン酸 nicotinamide adenine dinucleotide phosphate

「diaphorase」

　　[★]

ジアホラーゼ、ジアフォラーゼ

関: dihydrolipoamide dehydrogenase

リンク元	「NADPHジアフォラーゼ」「NADPH dehydrogenase」「NADPHジアホラーゼ」
関連記事	「NADPH」「NAD」「NADP」「diaphorase」

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NADPH diaphorase