NADP

出典: meddic

ニコチンアミドアデニンジヌクレオチドリン酸 nicotinamide adenine dinucleotide phosphate

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/01 11:30:54」(JST)

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英文文献

  • Biochemical and Biophysical Methods to Examine the Effects of Site-Directed Mutagenesis on Enzymatic Activities and Interprotein Interactions.
  • Kinoshita M1, Kim JY1, Lin Y1, Markova N1, Hase T1, Lee YH2.
  • Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2017;1498:439-460.
  • Mutations in proteins often affect interactions with partner molecules, sequentially changing their activities and functions. In order to examine mutagenic effects, we herein describe practical and detailed protocols for enzymatic activity assays using ferredoxin (Fd)-NADP+ reductase (FNR) and sulfi
  • PMID 27709594
  • Establishment of an effective TLC bioautographic method for the detection of Mycobacterium tuberculosis H37Ra phosphoglucose isomerase inhibition by phosphoenolpyruvate.
  • Paradowska K1, Polak B2, Chomicki A2, Ginalska G1.
  • Journal of enzyme inhibition and medicinal chemistry.J Enzyme Inhib Med Chem.2016 Dec;31(6):1712-7. doi: 10.3109/14756366.2016.1151012. Epub 2016 Mar 17.
  • A bioautographic assay based on thin layer chromatography was developed for phosphoenolpyruvate (PEP) detecting as a known but rarely studied inhibitor of phosphoglucose isomerase (PGI). The protocol with NADP(+)/NBT/PMS (β-nicotinamide adenine dinucleotide phosphate/nitrotetrazolium blue chloride/
  • PMID 26986942
  • Thylakoid membrane model of the Chl a fluorescence transient and P700 induction kinetics in plant leaves.
  • Belyaeva NE1, Bulychev AA2, Riznichenko GY2, Rubin AB2.
  • Photosynthesis research.Photosynth Res.2016 Dec;130(1-3):491-515. Epub 2016 Jul 1.
  • A new Thylakoid model is presented, which describes in detail the electron/proton transfer reactions between membrane protein complexes including photosystems II and I (PSII, PSI), cytochrome (Cyt) b 6 f, mobile plastoquinone PQ pool in the thylakoid membrane, plastocyanin in lumen and ferredoxin in
  • PMID 27368165

和文文献

  • Role of the C-terminal extension stacked on the re-face of the isoalloxazine ring moiety of the flavin adenine dinucleotide prosthetic group in ferredoxin-NADP+ oxidoreductase from Bacillus subtilis
  • Seo Daisuke,Asano Tomoya,Komori Hirofumi,Sakurai Takeshi
  • Plant Physiology and Biochemistry 81, 143-148, 2014-08
  • … Ferredoxin-NADP+ oxidoreductase [EC 1.18.1.2] from Bacillus subtilis (BsFNR) is homologous to the bacterial NADPH-thioredoxin reductase, but possesses a unique C-terminal extension that covers the re-face of the isoalloxazine ring moiety of the flavin adenine dinucleotide (FAD) prosthetic group. …
  • NAID 120005411656
  • Characterization of a thermostable 2,4-diaminopentanoate dehydrogenase from Fervidobacterium nodosum Rt17-B1.
  • Fukuyama Sadanobu,Mihara Hisaaki,Miyake Ryoma,Ueda Makoto,Esaki Nobuyoshi,Kurihara Tatsuo
  • Journal of bioscience and bioengineering 117(5), 551-556, 2014-05
  • … 2,4-Diaminopentanoate dehydrogenase (2,4-DAPDH), which is involved in the oxidative ornithine degradation pathway, catalyzes the NAD(+)- or NADP(+)-dependent oxidative deamination of (2R,4S)-2,4-diaminopentanoate (2,4-DAP) to form 2-amino-4-oxopentanoate. … The purified protein catalyzed the reduction of NAD(+) and NADP(+) in the presence of 2,4-DAP, indicating that the protein is a 2,4-DAPDH. …
  • NAID 120005466632
  • Characterization of a thermostable 2,4-diaminopentanoate dehydrogenase from Fervidobacterium nodosum Rt17-B1(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
  • Fukuyama Sadanobu,Mihara Hisaaki,Miyake Ryoma,Ueda Makoto,Esaki Nobuyoshi,Kurihara Tatsuo
  • Journal of bioscience and bioengineering 117(5), 551-556, 2014-05
  • … 2,4-Diaminopentanoate dehydrogenase (2,4-DAPDH), which is involved in the oxidative ornithine degradation pathway, catalyzes the NAD^+- or NADP^+-dependent oxidative deamination of (2R,4S)-2,4-diaminopentanoate (2,4-DAP) to form 2-amino-4-oxopentanoate. … The purified protein catalyzed the reduction of NAD^+ and NADP^+ in the presence of 2,4-DAP, indicating that the protein is a 2,4-DAPDH. …
  • NAID 110009823129

関連リンク

NADP+およびNADPHはNAD+と同様、生体内の電子伝達に寄与しているが、中でも 有名なのが光合成の電子伝達物質としての役割である。また、解糖系のエントナー- ドウドロフ経路や脂肪酸や ...

関連画像

nad and nadp differ only in the presence nadph is an electron carrier the molecule previous 9 of 18 nextnon sono disponibili versioni a Figure 1.once two electrons have been transferred


★リンクテーブル★
リンク元ニコチンアミドアデニンジヌクレオチド」「ニコチンアミドアデニンジヌクレオチドリン酸
拡張検索NADPHオキシダーゼ」「NADP+」「フェレドキシン-NADP+レダクターゼ
関連記事NA

ニコチンアミドアデニンジヌクレオチド」

  [★]

nicotinamide adenine dinucleotide, NAD, NAD+
ビタミンビタミンB3ナイアシンニコチン酸ニコチンアミドNADP

機能

補酵素

  • 酸化還元酵素の補酵素 プロトンのキャリアー(あるいは電子受容体)と考えることができる。
NAD+ + H+ + 2e- → NADH
NAD+ + AH2 → NADH + H+ + A</span>
  • TCA回路や脂肪酸のβ酸化で用いられる。
  • ニコチンアミドに由来するピリジン環でプロトンを受容する。

基質

NAD and NADP are active in adenine diphosphate–ribose transfer reactions involved in DNA repair and calcium mobilization(HIM.443)
  • DNAリガーゼ
  • ADPリボシル反応

生合成

  • 肝臓
  • 1. トリプトファン → キノリン酸 →
  • 2. ニコチン酸、ニコチンアミド →

NADとNADHの比

  • 組織が十分に酸素を得ているとき:↑NAD/NADH  ← 生成された還元力が酸化的リン酸化によるATPの産生に十分使われている状態
  • 梗塞や運動時:↓NAD/NADH

NADHとNADPHの比

  • NADH:異化:各種の基質の還元剤 → 基質を脱水素しエネルギーを得る
  • NADPH:同化:合成反応の還元剤

臨床関連

  • NADの欠乏



ニコチンアミドアデニンジヌクレオチドリン酸」

  [★]

nicotinamide adenine dinucleotide phosphate NADP
NADP+トリホスホピリジンヌクレオチド triphosphopyridine nucleotide TPN
NADPH



NADPHオキシダーゼ」

  [★]

NADPH oxidase, 英:NADPH-oxidase
NADPH酸化酵素NADPH-オキシダーゼ
ミエロペルオキシダーゼリソソームファゴリソソーム


first aid step1 2006 p.89

臨床関連

  • catalase positive organismの感染を受けやすい


NADP+」

  [★] ニコチンアミドアデニンジヌクレオチドリン酸 nicotinamide adenine dinucleotide phosphate

フェレドキシン-NADP+レダクターゼ」

  [★] フェレドキシン-NADP+還元酵素


NA」

  [★]


"http://meddic.jp/NADP" より作成


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