NAD+

出典: meddic

nicotinamide adenine dinucleotide
nicotinamide adenine dinucleotide


nicotinamide adenine dinucleotide
nicotinamide adenine dinucleotide

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/30 11:42:48」(JST)

wiki ja

[Wiki ja表示]

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

英文文献

  • A pseudo triple-enzyme cascade amplified aptasensor for thrombin detection based on hemin/G-quadruplex as signal label.
  • Yi H1, Xu W2, Yuan Y1, Bai L1, Wu Y1, Chai Y1, Yuan R1.Author information 1Key Laboratory on Luminescence and Real-Time Analysis, School of Chemistry and Chemical Engineering, Southwest University, The Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Chongqing 400715, PR China.2Key Laboratory on Luminescence and Real-Time Analysis, School of Chemistry and Chemical Engineering, Southwest University, The Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Chongqing 400715, PR China. Electronic address: xwju@swu.edu.cn.AbstractIn this work, a pseudo triple-enzyme cascade amplified electrochemical aptasensor based on hemin/G-quadruplex as signal label for thrombin (TB) was constructed and the amplified electrochemical signal was achieved by the corporate catalysis of alcohol dehydrogenase-graphene sheets (ADH-GSs) bionanocomposite and hemin/G-quadruplex, which simultaneously acted as NADH oxidase and HRP-mimicking DNAzyme. Through "sandwich" reaction, hemin/G-quadruplex labeled gold nanoparticles-ADH-GSs bionanocomposite (AuNPs-ADH-GSs) was captured on electrode surface and thus obtained the electrochemical signal. After the addition of ethanol into the electrolytic cell, ADH availably catalyzed the oxidation of ethanol with the reduction of NAD(+) to NADH. Then, hemin/G-quadruplex as NADH oxidase catalyzed the oxidization of NADH, accompanying with the production of H2O2. Simultaneously, hemin/G-quadruplex as HRP-mimicking DNAzyme catalyzed the reduction of the generated H2O2. Such a catalysis strategy greatly promoted the electron transfer of hemin and resulted in the specific enhancement of electrochemical signal. The proposed TB aptasensor achieved a linear range of 1pM-50nM with a detection limit of 0.3pM (defined as S/N=3). In addition, it showed satisfying stability and reproducibility, good specificity and sensitivity, indicating promising application for the detection of various proteins in clinical analysis.
  • Biosensors & bioelectronics.Biosens Bioelectron.2014 Apr 15;54:415-20. doi: 10.1016/j.bios.2013.11.036. Epub 2013 Nov 18.
  • In this work, a pseudo triple-enzyme cascade amplified electrochemical aptasensor based on hemin/G-quadruplex as signal label for thrombin (TB) was constructed and the amplified electrochemical signal was achieved by the corporate catalysis of alcohol dehydrogenase-graphene sheets (ADH-GSs) bionanoc
  • PMID 24296062
  • Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress.
  • Clarke NE1, Belyaev ND1, Lambert DW2, Turner AJ1.Author information 1*School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K.2†Integrated Biosciences, School of Clinical Dentistry, University of Sheffield, Sheffield S10 2TA, U.K.AbstractACE2 (angiotensin-converting enzyme 2) counterbalances the actions of ACE (angiotensin-converting enzyme) by metabolizing its catalytic product, the vasoactive and fibrogenic peptide AngII (angiotensin II), into Ang-(1-7) [angiotensin-(1-7)]. Enhanced ACE2 expression may be protective in diabetes, cardiovascular disease and cancer. However, relatively little is known about the specific physiological factors regulating ACE2 expression. In the present paper, we show, by Western blotting and qPCR (quantitative real-time PCR), that ACE2 expression is increased under conditions of cell stress, including hypoxic conditions, IL (interleukin)-1β treatment and treatment with the AMP mimic AICAR (5-amino-4-imidazolecarboxamide riboside). The NAD+-dependent deacetylase SIRT1 (silent information regulator T1) was found to be up-regulated after AICAR treatment but, conversely, was down-regulated after IL-1β treatment. ChIP analysis demonstrated that SIRT1 bound to the ACE2 promoter and that binding was increased after AICAR treatment, but decreased after IL-1β treatment. Inhibition of SIRT1 activity ablated the AICAR-induced increase in ACE2. In conclusion, we have established that the expression of the ACE2 transcript is controlled by the activity of SIRT1 under conditions of energy stress.
  • Clinical science (London, England : 1979).Clin Sci (Lond).2014 Apr 11;126(7):507-16. doi: 10.1042/CS20130291.
  • ACE2 (angiotensin-converting enzyme 2) counterbalances the actions of ACE (angiotensin-converting enzyme) by metabolizing its catalytic product, the vasoactive and fibrogenic peptide AngII (angiotensin II), into Ang-(1-7) [angiotensin-(1-7)]. Enhanced ACE2 expression may be protective in diabetes, c
  • PMID 24147777
  • Lipoic acid prevents fructose-induced changes in liver carbohydrate metabolism: Role of oxidative stress.
  • Castro MC1, Francini F1, Gagliardino JJ1, Massa ML2.Author information 1CENEXA -Centro de Endocrinología Experimental y Aplicada (UNLP-CONICET LA PLATA, Centro Colaborador OPS/OMS), Facultad de Ciencias Médicas UNLP, La Plata, Argentina.2CENEXA -Centro de Endocrinología Experimental y Aplicada (UNLP-CONICET LA PLATA, Centro Colaborador OPS/OMS), Facultad de Ciencias Médicas UNLP, La Plata, Argentina. Electronic address: marialmassa@hotmail.com.AbstractBACKGROUND: Fructose administration rapidly induces oxidative stress that triggers compensatory hepatic metabolic changes. We evaluated the effect of an antioxidant, R/S-α-lipoic acid on fructose-induced oxidative stress and carbohydrate metabolism changes.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2014 Mar;1840(3):1145-51. doi: 10.1016/j.bbagen.2013.12.005. Epub 2013 Dec 19.
  • BACKGROUND: Fructose administration rapidly induces oxidative stress that triggers compensatory hepatic metabolic changes. We evaluated the effect of an antioxidant, R/S-α-lipoic acid on fructose-induced oxidative stress and carbohydrate metabolism changes.METHODS: Wistar rats were fed a standard c
  • PMID 24361606

和文文献

  • Identification and characterization of a human mitochondrial NAD kinase.
  • Ohashi Kazuto,Kawai Shigeyuki,Murata Kousaku
  • Nature communications 3, 2012-12-04
  • NAD kinase is the sole NADP(+) biosynthetic enzyme. … Despite the great significance of NADP(+), to date no mitochondrial NAD kinase has been identified in human, and the source of human mitochondrial NADP(+) remains elusive. … Here we present evidence demonstrating that a human protein of unknown function, C5orf33, is a human mitochondrial NAD kinase; …
  • NAID 120005147840
  • エネルギー代謝を制御する脱アセチル化酵素サーチュインのケミカルバイオロジー (特集 蛋白構造 : 機能連関解析と治療薬開発への応用)
  • 伊藤 昭博,吉田 稔
  • 内分泌・糖尿病・代謝内科 35(6), 508-514, 2012-12-00
  • NAID 40019554215

関連リンク

また、波長340nmの紫外線をNADHのみが良く吸収し、NAD+ ⇔ NADHの変化は波長 340nmあるいは339nmの吸光度の測定によって容易に調べることができる。脱水素 酵素活性測定にはこの方法が良く用いられている。 NAD+およびNADHの二電子酸化 ...
NAD+キナーゼ. 出典: フリー百科事典『ウィキペディア(Wikipedia)』. 移動: 案内、 検索 ... この「NAD+キナーゼ」は、化学に関連した書きかけ項目です。この記事を加筆・訂正 などしてくださる協力者を求めています(プロジェクト:化学/Portal:化学)。

関連画像


押しても画像が表示されない場合はサーバが混雑しています。2週間ほどあけて、再度押下してください。


★リンクテーブル★
リンク元ニコチンアミドアデニンジヌクレオチド
拡張検索NAD+依存DNAリガーゼ
関連記事N」「NA

ニコチンアミドアデニンジヌクレオチド」

  [★]

nicotinamide adenine dinucleotide, NAD, NAD+
ビタミンビタミンB3ナイアシンニコチン酸ニコチンアミドNADP

機能

補酵素

  • 酸化還元酵素の補酵素 プロトンのキャリアー(あるいは電子受容体)と考えることができる。
NAD+ + H+ + 2e- → NADH
NAD+ + AH2 → NADH + H+ + A</span>
  • TCA回路や脂肪酸のβ酸化で用いられる。
  • ニコチンアミドに由来するピリジン環でプロトンを受容する。

基質

NAD and NADP are active in adenine diphosphate–ribose transfer reactions involved in DNA repair and calcium mobilization(HIM.443)
  • DNAリガーゼ
  • ADPリボシル反応

生合成

  • 肝臓
  • 1. トリプトファン → キノリン酸 →
  • 2. ニコチン酸、ニコチンアミド →

NADとNADHの比

  • 組織が十分に酸素を得ているとき:↑NAD/NADH  ← 生成された還元力が酸化的リン酸化によるATPの産生に十分使われている状態
  • 梗塞や運動時:↓NAD/NADH

NADHとNADPHの比

  • NADH:異化:各種の基質の還元剤 → 基質を脱水素しエネルギーを得る
  • NADPH:同化:合成反応の還元剤

臨床関連

  • NADの欠乏



NAD+依存DNAリガーゼ」

  [★]

NAD+-dependent DNA ligase
DNAリガーゼ


N」

  [★]

WordNet   license wordnet

「the 14th letter of the Roman alphabet」
n

PrepTutorEJDIC   license prepejdic

「nitrogenの化学記号」

NA」

  [★]


"http://meddic.jp/NAD%2B" より作成


★コメント★

[メモ入力エリア]
※コメント5000文字まで
ニックネーム:
コメント:




表示
個人用ツール


  meddic.jp

リンク
連絡
週間・日々の人気記事
最近7日間の人気記事
 タイトル表示
1マーフィー徴候 18
2narrow segment 16
3" wounds are made"  15
4グレイ症候群 15
5"phenoxypolyethoxylethanol" 15
6ロイシンエンケファリン 13
7硝酸ミコナゾール 11
8Common Laboratory Equipment 11
9content 10
10だいすいたいしんけい 9
11粟粒結核と肉下種 9
12全身性ヒマン細胞小 9
13細胞内寄生菌 9
14kligler培地 原理 9
15不整脈  9
16角膜反射 中枢 9
17膜性骨化 8
18ソルデム 8
19ハプロ不全 疾患 8
20日本多毛 8

昨日の人気記事
 タイトル表示
1" wounds are made"  15
2kligler培地 原理 9
3kligler培地 硫化鉄 4
4ǸCαꥦ륹ΤǤ뤳ȤŦƤ֤Ƥ 4
5歳の女性。右目の疼痛、充血および霧視を主訴に来院した。眼底に異常を認めない。視力は右 0.9 (矯正不能)、左 1.2 (矯正不能)。眼圧は右 11 mmHg、左 12 mmHg。フルオレセイン染色後の前眼部写真 (別冊No. 5) を別に示す。 治療薬として適切なのはどれか。 4
6胃癌 borrmann分類 3
7回復過程 3
8ジェンドラシック法 メカニズム 3
9しょうすいたいしんけい 3
10ラリンゲルマスク ゼリー 3
11ハッセルバッハ三角 3
12白内障 grade 3
13フォンギールケ病 3
14マッコーネルサイン 3
15小児骨折 好発部位 3
16咽頭神経叢 3
17低アルドステロン症 3
18フロマン徴候 3
19オーグメンチン 販売中止 3
20クスマウル徴候 3