WordNet

send a message from one computer to another to check whether it is reachable and active; "ping your machine in the office"
a sharp high-pitched resonant sound (as of a sonar echo or a bullet striking metal)
contact, usually in order to remind of something; "Ill ping my accountant--April 15 is nearing"
hit with a pinging noise; "The bugs pinged the lamp shade"
make a short high-pitched sound; "the bullet pinged when they struck the car"
the 16th letter of the Roman alphabet (同)p
the 14th letter of the Roman alphabet (同)n

PrepTutorEJDIC

(小銃弾などの)ピュー(ブーン)という音 / ピュー(ブーン)と音がする
parking
phosphorusの化学記号
nitrogenの化学記号
neodymiumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/07 10:51:21」(JST)

wiki en

Iofetamine (¹²³I) (INN; brand names Perfusamine, SPECTamine), or N-isopropyl-(¹²³I)-p-iodoamphetamine (IMP), is a lipid-soluble amine and radiopharmaceutical drug used in cerebral blood perfusion imaging with single photon emission computed tomography (SPECT).^[1]^[2]^[3] Labeled with the radioactive isotope iodine-123, it is approved for use in the United States as a diagnostic aid in determining the localization of and in the evaluation of non-lacunar stroke and complex partial seizures, as well as in the early diagnosis of Alzheimer's disease.^[1]^[2]

An analogue of amphetamine, iofetamine has shown to inhibit the reuptake of serotonin and norepinephrine as well as induce the release of these neurotransmitters and of dopamine with similar potencies to other amphetamines like d-amphetamine and p-chloroamphetamine.^[4]^[5] In addition, on account of its high lipophilicity, iofetamine rapidly penetrates the blood-brain-barrier.^[6] Accordingly, though not known to have been reported in the medical literature, iofetamine likely possesses psychostimulant and possibly entactogenic effects.^{[citation needed]} However, based on structure-activity relationships, it may also be highly neurotoxic to serotonergic and dopaminergic neurons similarly to most other para-halogenated amphetamines.^{[citation needed]}

References

^ ^a ^b Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 562. ISBN 978-3-88763-075-1. http://books.google.com/books?id=5GpcTQD_L2oC&pg=PA562. Retrieved 25 April 2012.
^ ^a ^b Druckenbrod RW, Williams CC, Gelfand MJ (January 1989). "Iofetamine hydrochloride I 123: a new radiopharmaceutical for cerebral perfusion imaging". DICP : the Annals of Pharmacotherapy 23 (1): 19–24. PMID 2655294.
^ Holman BL, Hill TC, Magistretti PL (1982). "Brain imaging with emission computed tomography and radiolabeled amines". Investigative Radiology 17 (3): 206–15. PMID 6811496.
^ Winchell HS, Horst WD, Braun L, Oldendorf WH, Hattner R, Parker H (October 1980). "N-isopropyl-[123I p-iodoamphetamine: single-pass brain uptake and washout; binding to brain synaptosomes; and localization in dog and monkey brain"]. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 21 (10): 947–52. PMID 6775056. http://jnm.snmjournals.org/cgi/pmidlookup?view=long&pmid=6775056.
^ de Jong BM, Feenstra MG, Ruijter JM, van Royen EA (March 1989). "Serotonin uptake in cerebral cortex cultures: imipramine-like inhibition by N-isopropyl-p-iodoamphetamine". Experimental Neurology 103 (3): 297–9. PMID 2920796.
^ Winchell HS, Baldwin RM, Lin TH (October 1980). "Development of I-123-labeled amines for brain studies: localization of I-123 iodophenylalkyl amines in rat brain". Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 21 (10): 940–6. PMID 7420195. http://jnm.snmjournals.org/cgi/pmidlookup?view=long&pmid=7420195.

UpToDate Contents

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1. イソプロピルアルコール中毒 isopropyl alcohol poisoning
2. 血清浸透圧ギャップ serum osmolal gap
3. 内視鏡の洗浄消毒 endoscope disinfection
4. メタノールおよびエチレングリコール中毒 methanol and ethylene glycol poisoning
5. 成人における薬物中毒への一般的アプローチ general approach to drug poisoning in adults

English Journal

Arterial spin-labeling MR imaging in moyamoya disease compared with SPECT imaging.

Noguchi T, Kawashima M, Irie H, Ootsuka T, Nishihara M, Matsushima T, Kudo S.SourceDepartment of Radiology, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, Japan.
European journal of radiology.Eur J Radiol.2011 Dec;80(3):e557-62. Epub 2011 Feb 18.
OBJECTIVE: Arterial spin-labeling (ASL) is a noninvasive magnetic resonance (MR) imaging method used to obtain brain perfusion information on various cerebrovascular diseases. We retrospectively compared the use of ASL-MRI and single-photon emission CT (SPECT) imaging to determine absolute cerebral
PMID 21315533

"Brush Sign" on susceptibility-weighted MR imaging indicates the severity of moyamoya disease.

Horie N, Morikawa M, Nozaki A, Hayashi K, Suyama K, Nagata I.SourceDepartment of Neurosurgery, Nagasaki University School of Medicine, Nagasaki, Japan. nobstanford@gmail.com
AJNR. American journal of neuroradiology.AJNR Am J Neuroradiol.2011 Oct;32(9):1697-702. Epub 2011 Jul 28.
BACKGROUND AND PURPOSE: SWI is a high spatial resolution MR imaging technique showing magnetic inhomogeneity that could demonstrate increased oxygen extraction in focal cerebral ischemia. The aim of this study was to investigate the characteristics in the signal intensity of DMVs by using SWI and to
PMID 21799039

Japanese Journal

In vivo radioactive metabolite analysis for individualized medicine: A basic study of a new method of CYP activity assay using 123I-IMP

Nuclear Medicine and Biology 42(2), 171-176, 2015-02
NAID 120005540368

123I-IMPグラフ解析定量法の換算式の再構築

日本放射線技術学会雑誌 71(7), 612-620, 2015
NAID 130005087914

Operator-bias-free Comparison of Quantitative Perfusion Maps Acquired with Pulsed-continuous Arterial Spin Labeling and Single-photon-emission Computed Tomography

Magnetic Resonance in Medical Sciences 13(4), 239-249, 2014
NAID 130004935508

Related Pictures

★リンクテーブル★

リンク元	「IMP」「N-イソプロピルパラヨードアンフェタミン」「iofetamine」
関連記事	「n」「P」「N」「ps」「p」

「IMP」

Iofetamine (¹²³I)
Systematic (IUPAC) name
	1-[4-(123I)iodophenyl]-N-isopropyl-2-propanamine
Clinical data
Pregnancy cat.	?
Legal status	℞ Prescription only
Pharmacokinetic data
Protein binding	<10%
Identifiers
CAS number	75917-92-9; 85068-76-4 (non-labeled); 95896-48-3 (123I-labeled HCl)
ATC code	V09AB01
PubChem	CID 156375
ChemSpider	137706
ChEMBL	CHEMBL1201308
Chemical data
Formula	C12H18123IN
Mol. mass	299.278 g/mol
	SMILES CC(C)NC(C)Cc1ccc(cc1)I;
	InChI InChI=1S/C12H18IN/c1-9(2)14-10(3)8-11-4-6-12(13)7-5-11/h4-7,9-10,14H,8H2,1-3H3/i13-4; Key:ISEHJSHTIVKELA-DCWJVSPSSA-N ;

　　[★]

「N-イソプロピルパラヨードアンフェタミン」

　　[★]

英: N-isopropyl-p-iodoamphetamine
同: IMP
関: 123I-IMP

脳SPECT造影剤

「iofetamine」

　　[★]

イオフェタミン

関: N-isopropyl-p-iodoamphetamine

「n」

　　[★]

n.

例数

関: number of experiment、sample size

pの前の[n]はmと記載する。synptom→symptom

「P」

　　[★]

「N」

　　[★]

アスパラギン asparagine
窒素(原子、分子)

「ps」

　　[★]

ピコ秒

時間単位

関: picosecond、psec

「p」

　　[★]

ピコ

10の-12乗

関: pico

[Index_Nominum_2000:_International_Drug_Directory-1] Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 562. ISBN 978-3-88763-075-1. http://books.google.com/books?id=5GpcTQD_L2oC&pg=PA562. Retrieved 25 April 2012.

[pmid2655294-2] Druckenbrod RW, Williams CC, Gelfand MJ (January 1989). "Iofetamine hydrochloride I 123: a new radiopharmaceutical for cerebral perfusion imaging". DICP : the Annals of Pharmacotherapy 23 (1): 19–24. PMID 2655294.

[pmid6811496-3] Holman BL, Hill TC, Magistretti PL (1982). "Brain imaging with emission computed tomography and radiolabeled amines". Investigative Radiology 17 (3): 206–15. PMID 6811496.

[pmid6775056-4] Winchell HS, Horst WD, Braun L, Oldendorf WH, Hattner R, Parker H (October 1980). "N-isopropyl-[123I p-iodoamphetamine: single-pass brain uptake and washout; binding to brain synaptosomes; and localization in dog and monkey brain"]. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 21 (10): 947–52. PMID 6775056. http://jnm.snmjournals.org/cgi/pmidlookup?view=long&pmid=6775056.

[pmid2920796-5] Jong BM, Feenstra MG, Ruijter JM, van Royen EA (March 1989). "Serotonin uptake in cerebral cortex cultures: imipramine-like inhibition by N-isopropyl-p-iodoamphetamine". Experimental Neurology 103 (3): 297–9. PMID 2920796.

[pmid7420195-6] Winchell HS, Baldwin RM, Lin TH (October 1980). "Development of I-123-labeled amines for brain studies: localization of I-123 iodophenylalkyl amines in rat brain". Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 21 (10): 940–6. PMID 7420195. http://jnm.snmjournals.org/cgi/pmidlookup?view=long&pmid=7420195.

匿名

検索

案内

案内

N-isopropyl-p-iodoamphetamine