同: NAT-2

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the 14th letter of the Roman alphabet (同)n

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nitrogenの化学記号
neodymiumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/24 22:19:31」(JST)

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N-acetyltransferase 2 (arylamine N-acetyltransferase), also known as NAT2, is an enzyme which in humans is encoded by the NAT2 gene.^[1]

Function

This gene encodes a type of N-acetyltransferase. The NAT2 isozyme functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in NAT2 are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near NAT2.^[2]

Phenotype prediction

The NAT2 acetylator phenotype can be inferred from NAT2 genotype (a combination of SNPs observed in a given individual).^[3]^[4]

References

^ Vatsis KP, Weber WW, Bell DA, Dupret JM, Evans DA, Grant DM, Hein DW, Lin HJ, Meyer UA, Relling MV (February 1995). "Nomenclature for N-acetyltransferases". Pharmacogenetics 5 (1): 1–17. doi:10.1097/00008571-199502000-00001. PMID 7773298.
^ "Entrez Gene: NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10.
^ "NAT2PRED: a computational predictor of the human N-AcetylTransferase-2 (NAT2) acetylator phenotype". State University of New York – Albany. http://nat2pred.rit.albany.edu/. Retrieved 2009-04-30.
^ Kuznetsov IB, McDuffie M, Moslehi R (May 2009). "A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype". Bioinformatics (Oxford, England) 25 (9): 1185–6. doi:10.1093/bioinformatics/btp121. PMC 2672629. PMID 19261719. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2672629/.

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English Journal

Enantioselective N-acetylation of 2-phenylglycine by an unusual N-acetyltransferase from Chryseobacterium sp.

Takenaka S, Honma Y, Yoshida K, Yoshida K.SourceDepartment of Agrobioscience, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai Nada-ku, Kobe, 657-8501, Japan, hakko3@kobe-u.ac.jp.
Biotechnology letters.Biotechnol Lett.2013 Jul;35(7):1053-9. doi: 10.1007/s10529-013-1172-z. Epub 2013 Mar 12.
The demand for D-2-phenylglycine used to synthesize semisynthetic antibiotics and pesticides is increasing. We have isolated a Chryseobacterium sp. that selectively transformed the L-form of racemic D,L-2-phenylglycine to (2S)-2-acetylamide-2-phenylacetic acid with a molar yield of 50 % and an enan
PMID 23479412

Rapid and intermediate N-acetylators are less susceptible to oxidative damage among 4,4'-methylenebis(2-chloroaniline) (MBOCA)-exposed workers.

Lin IS, Fan PL, Chen HI, Loh CH, Shih TS, Liou SH.SourceDepartment of Family Medicine & Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Neihu, Taipei, Taiwan, ROC.
International journal of hygiene and environmental health.Int J Hyg Environ Health.2013 Jul;216(4):515-20. doi: 10.1016/j.ijheh.2013.02.001. Epub 2013 Mar 13.
OBJECTIVES: In this study, we explored the association between a marker of oxidative stress, 8-hydroxydeoxyguanosine (8-OHdG), and genetic polymorphism of the carcinogen-metabolizing enzyme N-acetyltransferase 2 (NAT2) among 4,4'-methylenebis(2-chloroaniline) (MBOCA)-exposed workers.METHODS: The stu
PMID 23491024

Use of human in vitro skin models for accurate and ethical risk assessment: metabolic considerations.

Hewitt NJ, Edwards RJ, Fritsche E, Goebel C, Aeby P, Scheel J, Reisinger K, Ouédraogo G, Duche D, Eilstein J, Latil A, Kenny J, Moore C, Kuehnl J, Barroso J, Fautz R, Pfuhler S.Source* SWS, 64390 Erzhausen, Germany;
Toxicological sciences : an official journal of the Society of Toxicology.Toxicol Sci.2013 Jun;133(2):209-17. doi: 10.1093/toxsci/kft080. Epub 2013 Mar 28.
Several human skin models employing primary cells and immortalized cell lines used as monocultures or combined to produce reconstituted 3D skin constructs have been developed. Furthermore, these models have been included in European genotoxicity and sensitization/irritation assay validation projects
PMID 23539547

Japanese Journal

酵母に見いだした新規な抗酸化酵素「N-アセチルトランスフェラーゼMpr1」

高木博史,那須野亮
化学と生物 : 日本農芸化学会会誌 : 生命・食・環境 53(3), 148-155, 2015-03
NAID 40020383483

1P-061 Chryseobacterium sp. 5-3B由来N-アセチルトランスフェラーゼの特製解析(酵素学,酵素工学,一般講演)

竹中慎治,尾関貴博,田中耕生,吉田健一
日本生物工学会大会講演要旨集 66, 32, 2014-08-05
NAID 110009906142

N-acetyltransferase (nat) Is a Critical Conjunct of Photoperiodism between the Circadian System and Endocrine Axis in Antheraea pernyi

Ahmed A. M. Mohamed,Wang Qiushi,Bembenek Jadwiga,Ichihara Naoyuki,Hiragaki Susumu,Suzuki Takeshi,Takeda Makio
PLoS ONE 9(3), e92680, 2014-05
NAID 120005465538

「核酸増幅試験」

N-acetyltransferase 2 (arylamine N-acetyltransferase)
	; PDB rendering based on 2pfr.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2PFR
Identifiers
Symbols	NAT2; AAC2; NAT-2; PNAT
External IDs	OMIM: 612182 MGI: 97279 HomoloGene: 115468 ChEMBL: 2194 GeneCards: NAT2 Gene
EC number	2.3.1.5
Gene Ontology
Molecular function	• arylamine N-acetyltransferase activity;
Cellular component	• cytosol;
Biological process	• xenobiotic metabolic process; • small molecule metabolic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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