WordNet

street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"
the 14th letter of the Roman alphabet (同)n

PrepTutorEJDIC

酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
nitrogenの化学記号
neodymiumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/26 10:55:38」(JST)

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N-Acetylneuraminic acid (Neu5Ac or NANA) is the predominant sialic acid found in mammalian cells.

This negatively charged residue is found in complex glycans on mucins and glycoproteins found at the cell membrane. Neu5Ac residues are also found in glycolipids, such as gangliosides, a crucial component of neuronal membranes found in the brain.

Along with involvement in preventing infections (mucus associated with mucous membranes — mouth, nose, GI, respiratory tract), Neu5Ac acts as a receptor for influenza viruses, allowing attachment to mucous cells via hemagglutinin (an early step in acquiring influenzavirus infection).

Neu5Ac in the biology of bacterial pathogens

Neu5Ac is also important in the biology of a member of pathogenic bacteria ^[1]^[2] as it can used either as a nutrient, providing both carbon and nitrogen to the bacterium, or in some pathogens, can be activated and placed on the cell surface.^[1] Bacteria have evolved transporters for Neu5Ac to enable them to capture it from their environment and a number of these have been characterised including the NanT protein from Escherichia coli,^[3] the SiaPQM TRAP transporter from Haemophilus influenzae ^[4] and the SatABCD ABC transporter from Haemophilus ducreyi.^[5]

References

^ ^a ^b Severi E, Hood DW, Thomas GH (2007). "Sialic acid utilization by bacterial pathogens". Microbiology 153 (9): 2817–2822. doi:10.1099/mic.0.2007/009480-0. PMID 17768226.
^ Vimr ER, Kalivoda KA, Deszo EL, Steenbergen SM. (2004). "Diversity of microbial sialic acid metabolism.". Microbiol Mol Biol Rev 68 (1): 132–153. doi:10.1128/mmbr.68.1.132-153.2004. PMC 362108. PMID 15007099.
^ Vimr ER, Troy FA. (1985). "Identification of an inducible catabolic system for sialic acids (nan) in Escherichia coli". J. Bacteriol. 164 (2): 845–853. PMC 214328. PMID 3902799.
^ Severi E, Randle G, Kivlin P, Whitfield K, Young R, Moxon R, Kelly D, Hood D, Thomas GH. (2005). "Sialic acid transport in Haemophilus influenzae is essential for lipopolysaccharide sialylation and serum resistance and is dependent on a novel tripartite ATP-independent periplasmic transporter". Mol. Microbiol. 58 (4): 1173–1185. doi:10.1111/j.1365-2958.2005.04901.x. PMID 16262798.
^ Post DM, Mungur R, Gibson BW, Munson RS Jr. (2005). "Identification of a novel sialic acid transporter in Haemophilus ducreyi.". Infect Immun 73 (10): 6727–35. doi:10.1128/IAI.73.10.6727-6735.2005. PMC 1230923. PMID 16177350.

UpToDate Contents

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1. 尿酸のバランス uric acid balance
2. 出産時の臍帯血酸塩基分析 umbilical cord blood acid base analysis at delivery
3. 妊娠中の葉酸補充 folic acid supplementation in pregnancy
4. ポルフィリン症：概要 porphyrias an overview
5. 疾患予防におけるビタミン補給 vitamin supplementation in disease prevention

English Journal

A rapid and nondestructive method to determine the distribution map of protein, carbohydrate and sialic acid on Edible bird's nest by hyper-spectral imaging and chemometrics.

Shi J1, Hu X1, Zou X2, Zhao J1, Zhang W1, Holmes M3, Huang X1, Zhu Y1, Li Z1, Shen T1, Zhang X1.
Food chemistry.Food Chem.2017 Aug 15;229:235-241. doi: 10.1016/j.foodchem.2017.02.075. Epub 2017 Feb 20.
PMID 28372169

Application of surface enhanced Raman spectroscopy as a diagnostic system for hypersialylated metastatic cancers.

Shashni B1, Horiguchi Y1, Kurosu K1, Furusho H2, Nagasaki Y3.
Biomaterials.Biomaterials.2017 Jul;134:143-153. doi: 10.1016/j.biomaterials.2017.04.038. Epub 2017 Apr 21.
PMID 28460336

Stereoselective Synthesis of the Equatorial Glycosides of Legionaminic Acid.

Popik O1, Dhakal B1, Crich D1.
The Journal of organic chemistry.J Org Chem.2017 Jun 16;82(12):6142-6152. doi: 10.1021/acs.joc.7b00746. Epub 2017 Jun 2.
PMID 28530837

Japanese Journal

シアル酸補充療法 : GNEミオパチー(縁取り空胞を伴う遠位型ミオパチー)治療への試み (特集酵素補充療法)

森まどか,西野一三
Brain and nerve : 神経研究の進歩 67(9), 1115-1123, 2015-09
NAID 40020572981

Production and Purification of Secretory Simian Cytidine Monophosphate-N-acetylneuraminic Acid Hydroxylase Using Baculovirus-Protein Expression System

Takahashi Tadanobu,Kawagishi Sawako,Funahashi Hiroki [他],Hayashi Nonoka,Suzuki Takashi
Biological and Pharmaceutical Bulletin 38(8), 1220-1226, 2015
… Cytidine monophosphate (CMP) N-acetylneuraminic acid (Neu5Ac) hydroxylase (CMAH) is an essential enzyme for N-glycolylneuraminic acid (Neu5Gc) synthesis. … In addition, peptide-N-glycosidase F treatment of CMAH indicated that secretory CMAH was a glycoprotein with N-glycan. …
NAID 130005090642

Generation of α1,3-galactosyltransferase and cytidine monophospho-N-acetylneuraminic acid hydroxylase gene double-knockout pigs

MIYAGAWA Shuji,MATSUNARI Hitomi,WATANABE Masahito,NAKANO Kazuaki,UMEYAMA Kazuhiro,SAKAI Rieko,TAKAYANAGI Shuko,TAKEISHI Toki,FUKUDA Tooru,YASHIMA Sayaka,MAEDA Akira,EGUCHI Hiroshi,OKUYAMA Hiroomi,NAGAYA Masaki,NAGASHIMA Hiroshi
Journal of Reproduction and Development advpub(0), 2015
… These cells were subjected to an additional KO for the cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) gene. …
NAID 130005088822

Related Pictures

★リンクテーブル★

リンク元	「N-アセチルノイラミン酸」「NeuAc」「sialic acid」
拡張検索	「cytidine monophosphate N-acetylneuraminic acid」
関連記事	「n」「N」「Nd」

「N-アセチルノイラミン酸」

N-Acetylneuraminic acid
Names
	IUPAC name 5-(acetylamino)-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosonic acid
Identifiers
CAS Number	131-48-6
ChEBI	CHEBI:61599
ChemSpider	392681
Jmol 3D model	Interactive image
MeSH	N-Acetylneuraminic+Acid
PubChem	439197
	InChI InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,7+,8+,9+,11+/m0/s1 Key: SQVRNKJHWKZAKO-YRMXFSIDSA-N ; InChI=1/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,7+,8+,9+,11+/m0/s1 Key: SQVRNKJHWKZAKO-YRMXFSIDBI ;
	SMILES OC(=O)[C@@]1(O)C[C@H](O)[C@@H](NC(C)=O)[C@@H](O1)[C@H](O)[C@H](O)CO ;
Properties
Chemical formula	C11H19NO9
Molar mass	309.273 g/mol
Appearance	White crystalline powder
Melting point	186 °C (367 °F; 459 K) (decomposes)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references