N-アセチルガラクトサミン-4-スルファターゼ
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- the 14th letter of the Roman alphabet (同)n
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- nitrogenの化学記号
- neodymiumの化学記号
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/25 21:31:18」(JST)
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| N-acetylgalactosamine-4-sulfatase |
| Identifiers |
| EC number |
3.1.6.12 |
| CAS number |
55354-43-3 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
N-acetylgalactosamine-4-sulfatase (EC 3.1.6.12, chondroitinsulfatase, chondroitinase, arylsulfatase B, acetylgalactosamine 4-sulfatase, N-acetylgalactosamine 4-sulfate sulfohydrolase) is an enzyme with systematic name N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase.[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate
This enzazyme also acts on N-acetylglucosamine 4-sulfate.
References
- ^ Farooqui, A.A. (1976). "The desulphation of hexosamine sulphates by arylsulphatase B". Experientia. 32 (10): 1242–1244. doi:10.1007/BF01953071. PMID 976430.
- ^ Gorham, S.D.; Cantz, M. (1978). "Arylsulphatase B, an exo-sulphatase for chondroitin 4-sulphate tetrasaccharide". Hoppe-Seyler's Z. Physiol. Chem. 359 (12): 1811–1814. doi:10.1515/bchm2.1978.359.2.1811. PMID 738706.
- ^ Tsuji, M.; Nakanishi, Y.; Habuchi, H.; Ishihara, K.; Suzuki, S. (1980). "The common identity of UDP-N-acetylgalactosamine 4-sulfatase, nitrocatechol sulfatase (arylsulfatase), and chondroitin 4-sulfatase". Biochim. Biophys. Acta. 612 (2): 373–383. doi:10.1016/0005-2744(80)90120-5. PMID 7370276.
See also
External links
- N-acetylgalactosamine-4-sulfatase at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Hydrolase: esterases (EC 3.1)
|
|
3.1.1: Carboxylic
ester hydrolases |
- Cholinesterase
- Acetylcholinesterase
- Butyrylcholinesterase
- Pectinesterase
- 6-phosphogluconolactonase
- PAF acetylhydrolase
- Lipase
- Bile salt-dependent
- Gastric/Lingual
- Pancreatic
- Lysosomal
- Hormone-sensitive
- Endothelial
- Hepatic
- Lipoprotein
- Monoacylglycerol
- Diacylglycerol
|
|
| 3.1.2: Thioesterase |
- Palmitoyl protein thioesterase
- Ubiquitin carboxy-terminal hydrolase L1
- 4-hydroxybenzoyl-CoA thioesterase
|
|
| 3.1.3: Phosphatase |
- Alkaline phosphatase
- Acid phosphatase (Prostatic)/Tartrate-resistant acid phosphatase/Purple acid phosphatases
- Nucleotidase
- Glucose 6-phosphatase
- Fructose 1,6-bisphosphatase
- Protein phosphatase
- OCRL
- Pyruvate dehydrogenase phosphatase
- Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
- PTEN
- Phytase
- Inositol-phosphate phosphatase
- Protein phosphatase: Protein tyrosine phosphatase
- Protein serine/threonine phosphatase
- Dual-specificity phosphatase
|
|
| 3.1.4: Phosphodiesterase |
- Autotaxin
- Phospholipase
- Sphingomyelin phosphodiesterase
- PDE1
- PDE2
- PDE3
- PDE4A/PDE4B
- PDE5
- Lecithinase (Clostridium perfringens alpha toxin)
- Cyclic nucleotide phosphodiesterase
|
|
| 3.1.6: Sulfatase |
- arylsulfatase
- Arylsulfatase A
- Arylsulfatase B
- Arylsulfatase E
- Steroid sulfatase
- Galactosamine-6 sulfatase
- Iduronate-2-sulfatase
- N-acetylglucosamine-6-sulfatase
|
|
Nuclease (includes
deoxyribonuclease and
ribonuclease) |
| 3.1.11-16: Exonuclease |
| Exodeoxyribonuclease |
|
|
| Exoribonuclease |
|
|
|
| 3.1.21-31: Endonuclease |
| Endodeoxyribonuclease |
- Deoxyribonuclease I
- Deoxyribonuclease II
- Deoxyribonuclease IV
- Restriction enzyme
- UvrABC endonuclease
|
|
| Endoribonuclease |
- RNase III
- RNase H
- RNase P
- RNase A
- RNase T1
- RNA-induced silencing complex
|
|
| either deoxy- or ribo- |
- Aspergillus nuclease S1
- Micrococcal nuclease
|
|
|
|
Enzymes
|
|
| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
|
| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
|
| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
|
| Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
|
UpToDate Contents
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English Journal
- Arylsulfatase B (N-acetylgalactosamine-4-sulfatase): potential role as a biomarker in prostate cancer.
- Feferman L, Bhattacharyya S, Deaton R, Gann P, Guzman G, Kajdacsy-Balla A, Tobacman JK.Source1] Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA [2] Jesse Brown VA Medical Center, Chicago, IL, USA.
- Prostate cancer and prostatic diseases.Prostate Cancer Prostatic Dis.2013 Jul 9. doi: 10.1038/pcan.2013.18. [Epub ahead of print]
- Background:The enzyme arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) degrades chondroitin-4-sulfate (C4S) and is reduced in malignant colonic and mammary tissues but has not previously been evaluated in prostate cancer.Methods:ARSB immunostaining was performed on two tissue microarrays (T
- PMID 23835622
- Mucopolysaccharidosis type VI: a predominantly cardiac phenotype associated with homozygosity for p.R152W mutation in the ARSB gene.
- Jurecka A, Zakharova E, Cimbalistiene L, Gusina N, Kulpanovich A, Golda A, Opoka-Winiarska V, Piotrowska E, Voskoboeva E, Tylki-Szymańska A.SourceDepartment of Molecular Biology, University of Gdańsk, Gdańsk, Poland. ajurecka@gmail.com
- American journal of medical genetics. Part A.Am J Med Genet A.2013 Jun;161(6):1291-9. doi: 10.1002/ajmg.a.35905. Epub 2013 Apr 30.
- Mucopolysaccharidosis type VI (MPS VI) is a rare lysosomal, autosomal recessive storage disorder caused by deficient activity of N-acetylgalactosamine-4-sulfatase (ARSB). Approximately, 140 ARSB gene mutations have been identified; however, most are private mutations making genotype-phenotype correl
- PMID 23633437
- Spondyloepiphyseal Dysplasias and Bilateral Legg-Calvé-Perthes Disease: Diagnostic Considerations for Mucopolysaccharidoses.
- Mendelsohn NJ, Wood T, Olson RA, Temme R, Hale S, Zhang H, Read L, White KK.SourceDepartment of Medical Genetics, Children's Hospitals and Clinics of Minnesota, 2525 Chicago Avenue S., CSC 560, Minneapolis, MN, 55404, USA, nancy.mendelsohn@childrensmn.org.
- JIMD reports.JIMD Rep.2013 May 9. [Epub ahead of print]
- Mucopolysaccharidosis type VI (MPS VI, Maroteaux-Lamy syndrome, MIM 253200 ) is an autosomal recessive lysosomal storage disease (LSD) caused by decreased activity of arylsulfatase B (N-acetylgalactosamine 4-sulfatase) enzyme resulting in dermatan sulfate accumulation; mucopolysaccharidosis type IVA
- PMID 23657977
Japanese Journal
- Maroteaux-Lamy disease (Mucopolysaccharidosis VI), subtype A : deficiency of a N-acetylgalactosamine-4-sulfatase
Related Links
- a relatively high rate of immunotolerance towards recombinant human N-acetylgalactosamine-4-sulfatase can be achieved in MPS-VI cats with a shortcourse ... mucopolysaccharidosis type VI, i.e. MPS VI or Maroteaux-Lamy ...
- 1. Biochim Biophys Acta. 1995 Dec 12;1272(3):129-32. N-acetylgalactosamine-4-sulfatase: identification of four new mutations within the conserved sulfatase region causing mucopolysaccharidosis type VI. Simonaro CM(1 ...
★リンクテーブル★
[★]
- 英
- N-acetylgalactosamine-4-sulfatase
[★]
- 関
- number of experiment、sample size
- pの前の[n]はmと記載する。synptom→symptom
[★]
スルファターゼ、サルファターゼ、硫酸エステル加水分解酵素
[★]
[★]
アセチルガラクトサミン
- 関
- N-acetyl-D-galactosamine
[★]
ネオジム neodymium