同: GalNAc

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the 14th letter of the Roman alphabet (同)n

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nitrogenの化学記号
neodymiumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/02 01:46:57」(JST)

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N-Acetylgalactosamine (GalNAc), is an amino sugar derivative of galactose.

Function

In humans it is the terminal carbohydrate forming the antigen of blood group A.^[1]

It is typically the first monosaccharide that connects serine or threonine in particular forms of protein O-glycosylation.

N-Acetylgalactosamine is necessary for intercellular communication, and is concentrated in sensory nerve structures of both humans and animals.

References

^ Donald M. Marcus; Elvin A. Kabat; Gerald Schiffman (1964). "Immunochemical Studies on Blood Groups. XXXI. Destruction of Blood Group A Activity by an Enzyme from Clostridium tertium Which Deacetylates N-Acetylgalactosamine in Intact Blood Group Substances". Biochemistry. 3: 437–443. doi:10.1021/bi00891a023.

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English Journal

ASGPR-mediated uptake of multivalent glycoconjugates for drug delivery in hepatocytes.

Monestier M1, Charbonnier P2, Gateau C3, Cuillel M4, Robert F5, Lebrun C6, Mintz E7, Renaudet O8, Delangle P9.
Chembiochem : a European journal of chemical biology.Chembiochem.2016 Jan 19. doi: 10.1002/cbic.201600023. [Epub ahead of print]
The liver cells can be an essential target for drug delivery in many diseases. They express the asialoglycoprotein receptor (ASGPR) that promotes specific uptake by means of N-acetylgalactosamine (GalNAc) recognition. In this line, we designed two different chemical architectures to treat the Wilson
PMID 26781030

Lectin staining of the uterovaginal junction and sperm-storage tubule epithelia in broiler hens.

Bakst MR1, Bauchan G2.
Poultry science.Poult Sci.2016 Jan 14. pii: pev440. [Epub ahead of print]
Mammalian sperm bind to terminal carbohydrates associated with glycoconjugates on the apical surface of oviduct epithelial cells in the caudal region of the oviduct and undergo cellular and molecular modifications associated with capacitation prior to ovulation. In contrast, chicken sperm are stored
PMID 26769269

Combined albumin and bicarbonate adversely affects equine sperm-oviduct binding.

Leemans B1, Gadella BM2, Stout TA3, Sostaric E4, De Schauwer C5, Nelis HM6, Hoogewijs M7, Van Soom A8.
Reproduction (Cambridge, England).Reproduction.2016 Jan 11. pii: REP-15-0471. [Epub ahead of print]
In many species, sperm binding to oviduct epithelium is believed to be an essential step in generating a highly fertile capacitated sperm population primed for fertilization. In several mammalian species, this interaction is based on carbohydrate-lectin recognition. D-galactose has previously been c
PMID 26755687

Japanese Journal

Crystal structure of a symbiosis-related lectin from octocoral.

Glycobiology 25(9), 1016-1023, 2015-09
NAID 120005694184

Mannose-recognition mutant of the galactose/N-acetylgalactosamine-specific C-type lectin CEL-I engineered by site-directed mutagenesis

Biochimica et Biophysica Acta (BBA) - General Subjects 1850(7), 1457-1465, 2015-07
NAID 120005611344

Cloning and Characterization of a Novel Chondroitin Sulfate/Dermatan Sulfate 4-O-Endosulfatase from a Marine Bacterium

Journal of Biological Chemistry 290(12), 7823-7832, 2015-03-20
NAID 120005906912

「N-アセチルガラクトサミン」

N-Acetylgalactosamine
Names
	IUPAC name 2-(Acetylamino)-2-deoxy-D-galactose
	Other names GalNAc; 2-Acetamido-2-deoxy-D-galactose; N-Acetylchondrosamine; 2-Acetamido-2-deoxy-D-galactopyranose; N-Acetyl-D-galactosamine
Identifiers
CAS Number	1811-31-0
ChEBI	CHEBI:40356
ChemSpider	76020
Jmol 3D model	Interactive image
PubChem	84265
	InChI InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8+/m1/s1 Key: OVRNDRQMDRJTHS-CBQIKETKSA-N ; InChI=1/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8+/m1/s1 Key: OVRNDRQMDRJTHS-CBQIKETKBW ;
	SMILES O[C@@H](C(CO)O[C@H](O)[C@H]1NC(C)=O)[C@H]1O ;
Properties
Chemical formula	C8H15NO6
Molar mass	221.21 g/mol
Melting point	172 to 173 °C (342 to 343 °F; 445 to 446 K)
Hazards
S-phrases	S24/25
Related compounds
Related monosaccharides	N-Acetylglucosamine; Galactosamine; Galactose
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

　　[★]

英: N-acetylgalactosamine, GalNAc
同: N-アセチルコンドロサミン N-acetylchondrosamine、Nアセチルガラクトサミン

「N-acetylgalactosamine-4-sulfatase」

　　[★]

N-アセチルガラクトサミン-4-スルファターゼ

「n」

　　[★]

n.

例数

関: number of experiment、sample size

pの前の[n]はmと記載する。synptom→symptom

「N」

　　[★]

アスパラギン asparagine
窒素(原子、分子)

「acetylgalactosamine」

　　[★]

アセチルガラクトサミン

関: N-acetyl-D-galactosamine

「Nd」

　　[★] ネオジム neodymium 　

[1] Donald M. Marcus; Elvin A. Kabat; Gerald Schiffman (1964). "Immunochemical Studies on Blood Groups. XXXI. Destruction of Blood Group A Activity by an Enzyme from Clostridium tertium Which Deacetylates N-Acetylgalactosamine in Intact Blood Group Substances". Biochemistry. 3: 437–443. doi:10.1021/bi00891a023.

リンク元	「N-アセチルガラクトサミン」
拡張検索	「N-acetylgalactosamine-4-sulfatase」
関連記事	「n」「N」「acetylgalactosamine」「Nd」

匿名

検索

案内

案内

N-acetylgalactosamine