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English Journal
- Drug resistance in patients with leprosy in the United States.
- Williams DL, Lewis C, Sandoval FG, Robbins N, Keas S, Gillis TP, Scollard DM.Author information Laboratory Research Branch.AbstractMolecular drug susceptibility testing was performed on 39 US patients with leprosy. Of these, 2 had dapsone-resistant Mycobacterium leprae and 1 of these patients also had rifampin-resistant M. leprae. Even though antileprosy drug resistance occurs in this leprosy population, resistance does not appear to be a major problem.
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.Clin Infect Dis.2014 Jan;58(1):72-3. doi: 10.1093/cid/cit628. Epub 2013 Sep 24.
- Molecular drug susceptibility testing was performed on 39 US patients with leprosy. Of these, 2 had dapsone-resistant Mycobacterium leprae and 1 of these patients also had rifampin-resistant M. leprae. Even though antileprosy drug resistance occurs in this leprosy population, resistance does not app
- PMID 24065328
- Mycobacterium leprae is identified in the oral mucosa from paucibacillary and multibacillary leprosy patients.
- Morgado de Abreu MA, Roselino AM, Enokihara M, Nonogaki S, Prestes-Carneiro LE, Weckx LL, Alchorne MM.Author information Dermatology Unit, Presidente Prudente Regional Hospital, University of Oeste Paulista, Presidente Prudente, SP, Brazil; Department of Dermatology, São Paulo Federal University, São Paulo, SP, Brazil.AbstractIn leprosy, the nasal mucosa is considered as the principal route of transmission for the bacillus Mycobacterium leprae. The objective of this study was to identify M. leprae in the oral mucosa of 50 untreated leprosy patients, including 21 paucibacillary (PB) and 29 multibacillary (MB) patients, using immunohistochemistry (IHC), with antibodies against bacillus Calmette-Guérin (BCG) and phenolic glycolipid antigen-1 (PGL-1), and polymerase chain reaction (PCR), with MntH-specific primers for M. leprae, and to compare the results. The material was represented by 163 paraffin blocks containing biopsy samples obtained from clinically normal sites (including the tongue, buccal mucosa and soft palate) and visible lesions anywhere in the oral mucosa. All patients and 158 available samples were included for IHC study. Among the 161 available samples for PCR, 110 had viable DNA. There was viable DNA in at least one area of the oral mucosa for 47 patients. M. leprae was detected in 70% and 78% of patients using IHC and PCR, respectively, and in 94% of the patients by at least one of the two diagnostic methods. There were no differences in detection of M. leprae between MB and PB patients. Similar results were obtained using anti-BCG and anti-PGL-1 antibodies, and immunoreactivity occurred predominantly on free-living bacteria on the epithelial surface, with a predilection for the tongue. Conversely, there was no area of predilection according to the PCR results. M. leprae is present in the oral mucosa at a high frequency, implicating this site as a potential means of leprosy transmission.
- Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.Clin Microbiol Infect.2014 Jan;20(1):59-64. doi: 10.1111/1469-0691.12190. Epub 2013 Mar 8.
- In leprosy, the nasal mucosa is considered as the principal route of transmission for the bacillus Mycobacterium leprae. The objective of this study was to identify M. leprae in the oral mucosa of 50 untreated leprosy patients, including 21 paucibacillary (PB) and 29 multibacillary (MB) patients, u
- PMID 23473290
- Leprosy as a model of immunity.
- Degang Y, Nakamura K, Akama T, Ishido Y, Luo Y, Ishii N, Suzuki K.Author information Leprosy Research Center, National Institute of Infectious Diseases, 4-2-1 Aoba-cho, Higashimurayama, Tokyo 189-0002, Japan.Abstract Leprosy displays a spectrum of clinical manifestations, such as lepromatous and tuberculoid leprosy, and type I and II lepra reactions, which are thought to be a reflection of the host's immunological response against Mycobacterium leprae. Therefore, differential recognition of M. leprae, as well as its degraded components, and subsequent activation of cellular immunity will be an important factor for the clinical manifestation of leprosy. Although M. leprae mainly parasitizes tissue macrophages in the dermis and the Schwann cells of peripheral nerves, the presence of M. leprae in other organs, such as the liver, may also play important roles in the further modification of seesaw-like bipolar phenotypes of leprosy. Thus, leprosy is an exciting model for investigating the role of the human immune system in host defense and susceptibility to infection.
- Future microbiology.Future Microbiol.2014 Jan;9:43-54. doi: 10.2217/fmb.13.140.
- Leprosy displays a spectrum of clinical manifestations, such as lepromatous and tuberculoid leprosy, and type I and II lepra reactions, which are thought to be a reflection of the host's immunological response against Mycobacterium leprae. Therefore, differential recognition of M. leprae, as well
- PMID 24328380
Related Links
- 118 Proceedings of the Royal Irish Academy Franzblau, S G and O'Sullivan, J F 1988 Structure-activity relationships of selected phenazmes against Mycobactenum leprae in vitro Antimicrob Agents Chemother 32,
- Effective vaccination of mice against leprosy bacilli with subunits of Mycobactenum leprae. Infect. Immun (1990)
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