モントゴメリー腺
WordNet
- English general during World War II; won victories over Rommel in North Africa and led British ground forces in the invasion of Normandy (1887-1976) (同)Bernard Law Montgomery, Sir Bernard Law Montgomery, 1st Viscount Montgomery of Alamein
- Canadian novelist (1874-1942) (同)L. M. Montgomery, Lucy Maud Montgomery
- the state capital of Alabama on the Mobile River (同)capital of Alabama
- any of various organs that synthesize substances needed by the body and release it through ducts or directly into the bloodstream (同)secretory organ, secretor, secreter
PrepTutorEJDIC
- モントゴメリー(米国Alabama州の州都)
- (生物体内の)腺(せん)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/22 18:01:53」(JST)
[Wiki en表示]
| Areolar glands |
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Montgomery tubercles
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| Details |
| Latin |
glandulae areolares |
| Identifiers |
| TA |
A16.0.02.013 |
| FMA |
58090 |
| Anatomical terminology |
Areolar glands or Glands of Montgomery are sebaceous glands in the areola surrounding the nipple. The glands make oily secretions (lipoid fluid) to keep the areola and the nipple lubricated and protected. Volatile compounds in these secretions may also serve as an olfactory stimulus for newborn appetite.[1]
The portions of the gland visible on the skin's surface are called "Montgomery tubercles". The round bumps are found in the areola, and on the nipple itself. They can become exposed and raised when the nipple is stimulated. The skin over the surface opening is lubricated and tends to be smoother than the rest of the areola. The tubercles become more pronounced during pregnancy.
The number of glands can vary greatly, usually averaging from 4 to 28 per nipple.[2]
They are named after Dr. William Fetherstone Montgomery (1797–1859), an Irish obstetrician who first described them in 1837.[3][4]
See also
- Fissure of the nipple
- List of specialized glands within the human integumentary system
References
- ^ Doucet, Sébastien; Soussignan, Robert; Sagot, Paul; Schaal, Benoist (2009). Hausberger, Martine, ed. "The Secretion of Areolar (Montgomery's) Glands from Lactating Women Elicits Selective, Unconditional Responses in Neonates". PLoS ONE 4 (10): e7579. doi:10.1371/journal.pone.0007579. PMC 2761488. PMID 19851461.
- ^ Donovan, Debbi (January 1, 2010). "What are Montgomery's tubercles?".
- ^ synd/1513 at Who Named It?
- ^ Montgomery, William F. (1837). An exposition of the signs and symptoms of pregnancy, the period of human gestation, and the signs of delivery. London: Sherwood, Gilbert and Piper. OCLC 738411950. [page needed]
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Anatomy of the breast
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| Structure |
- Nipple
- Areola
- Mammary gland
- Cooper's ligament
- Inframammary fold
- Intermammary cleft
- Retromammary space
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| Other |
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Index of the breast
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| Description |
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| Disease |
- Congenital
- Neoplasms and cancer
- Other
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| Treatment |
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UpToDate Contents
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English Journal
- Development of monoclonal antibodies against human CYP11B1 and CYP11B2.
- Gomez-Sanchez CE1, Qi X2, Velarde-Miranda C2, Plonczynski MW2, Parker CR3, Rainey W4, Satoh F5, Maekawa T5, Nakamura Y5, Sasano H5, Gomez-Sanchez EP6.Author information 1Endocrine Section, G.V. (Sonny) Montgomery VA Medical Center, USA; Endocrinology, University of Mississippi Medical Center, USA. Electronic address: cgomez-sanchez@umc.edu.2Endocrinology, University of Mississippi Medical Center, USA.3Department of Obstetrics and Gynecology, University of Alabama, Birmingham, AL, USA.4Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.5Tohoku University, Department of Pathology, Tohoku University, Sendai, Japan.6Endocrine Section, G.V. (Sonny) Montgomery VA Medical Center, USA; Endocrinology, University of Mississippi Medical Center, USA; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.Abstract1. The final enzymes in the biosynthesis of aldosterone and cortisol are by the cytochrome P450 CYP11B2 and CYP11B1, respectively. The enzymes are 93% homologous at the amino acid level and specific antibodies have been difficult to generate. 2. Mice and rats were immunized with multiple peptides conjugated to various immunogenic proteins and monoclonal antibodies were generated. The only peptide sequences that generated specific antibodies were amino acids 41-52 for the CYP11B2 and amino acids 80-90 for the CYP11B1 enzyme. 3. The mouse monoclonal CYP11B2-41 was specific and sensitive for use in western blots and produced specific staining of the zona glomerulosa of normal adrenal glands. The rat monoclonal CYP11B1-80 also detected a single band by western blot and detected only the zona fasciculata. Triple immunofluorescence of the adrenal demonstrated that the CYP11B1 and the CYP11B2 did not co-localize, while as expected the CYP11B1 co-localized with the 17α-hydroxylase.
- Molecular and cellular endocrinology.Mol Cell Endocrinol.2014 Mar 5;383(1-2):111-7. doi: 10.1016/j.mce.2013.11.022. Epub 2013 Dec 8.
- 1. The final enzymes in the biosynthesis of aldosterone and cortisol are by the cytochrome P450 CYP11B2 and CYP11B1, respectively. The enzymes are 93% homologous at the amino acid level and specific antibodies have been difficult to generate. 2. Mice and rats were immunized with multiple peptides co
- PMID 24325867
- Targeted androgen pathway suppression in localized prostate cancer: a pilot study.
- Mostaghel EA1, Nelson PS, Lange P, Lin DW, Taplin ME, Balk S, Ellis W, Kantoff P, Marck B, Tamae D, Matsumoto AM, True LD, Vessella R, Penning T, Hunter Merrill R, Gulati R, Montgomery B.Author information 1Elahe A. Mostaghel, Rachel Hunter Merrill, and Roman Gulati, Fred Hutchinson Cancer Research Center; Elahe A. Mostaghel, Peter S. Nelson, Paul Lange, Daniel W. Lin, William Ellis, Robert Vessella, and Bruce Montgomery, University of Washington; Brett Marck, Alvin M. Matsumoto, and Lawrence D. True, Veterans Affairs Puget Sound Health Care System, Seattle, WA; Mary Ellen Taplin and Philip Kantoff, Dana-Farber Cancer Institute, Harvard Medical School; Steven Balk, Beth Israel Deaconess Medical Center, Boston, MA; and Daniel Tamae and Trevor Penning, University of Pennsylvania, Philadelphia, PA.AbstractPURPOSE: Ligand-mediated activation of the androgen receptor (AR) is critical for prostate cancer (PCa) survival and proliferation. The failure to completely ablate tissue androgens may limit suppression of PCa growth. We evaluated combinations of CYP17A and 5-α-reductase inhibitors for reducing prostate androgen levels, AR signaling, and PCa volumes.
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology.J Clin Oncol.2014 Jan 20;32(3):229-37. doi: 10.1200/JCO.2012.48.6431. Epub 2013 Dec 9.
- PURPOSE: Ligand-mediated activation of the androgen receptor (AR) is critical for prostate cancer (PCa) survival and proliferation. The failure to completely ablate tissue androgens may limit suppression of PCa growth. We evaluated combinations of CYP17A and 5-α-reductase inhibitors for reducing pr
- PMID 24323034
- Minireview: potassium channels and aldosterone dysregulation: is primary aldosteronism a potassium channelopathy?
- Gomez-Sanchez CE1, Oki K.Author information 1Endocrinology Division (C.E.G.-S.), G. V. (Sonny) Montgomery Veterans Affairs Medical Center and University of Mississippi Medical Center, Jackson, Mississippi 39216; and Department of Endocrinology and Diabetes (K.O.), Hiroshima University Hospital, Hiroshima 734-8551, Japan.AbstractPrimary aldosteronism is the most common form of secondary hypertension and has significant cardiovascular consequences. Aldosterone-producing adenomas (APAs) are responsible for half the cases of primary aldosteronism, and about half have mutations of the G protein-activated inward rectifying potassium channel Kir3.4. Under basal conditions, the adrenal zona glomerulosa cells are hyperpolarized with negative resting potentials determined by membrane permeability to K(+) mediated through various K(+) channels, including the leak K(+) channels TASK-1, TASK-3, and Twik-Related Potassium Channel 1, and G protein inward rectifying potassium channel Kir3.4. Angiotensin II decreases the activity of the leak K(+) channels and Kir3.4 channel and decreases the expression of the Kir3.4 channel, resulting in membrane depolarization, increased intracellular calcium, calcium-calmodulin pathway activation, and increased expression of cytochrome P450 aldosterone synthase (CYP11B2), the last enzyme for aldosterone production. Somatic mutations of the selectivity filter of the Kir3.4 channel in APA results in loss of selectivity for K(+) and entry of sodium, resulting in membrane depolarization, calcium mobilization, increased CYP11B2 expression, and hyperaldosteronism. Germ cell mutations cause familial hyperaldosteronism type 3, which is associated with adrenal zona glomerulosa hyperplasia, rather than adenoma. Less commonly, somatic mutations of the sodium-potassium ATPase, calcium ATPase, or the calcium channel calcium channel voltage-dependent L type alpha 1D have been found in some APAs. The regulation of aldosterone secretion is exerted to a significant degree by activation of membrane K(+) and calcium channels or pumps, so it is not surprising that the known causes of disorders of aldosterone secretion in APA have been channelopathies, which activate mechanisms that increase aldosterone synthesis.
- Endocrinology.Endocrinology.2014 Jan;155(1):47-55. doi: 10.1210/en.2013-1733. Epub 2013 Dec 20.
- Primary aldosteronism is the most common form of secondary hypertension and has significant cardiovascular consequences. Aldosterone-producing adenomas (APAs) are responsible for half the cases of primary aldosteronism, and about half have mutations of the G protein-activated inward rectifying potas
- PMID 24248457
Japanese Journal
- Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract, Pancreas andSalivary Glands of the Rat and Mouse
Related Links
- Areolar glands or Glands of Montgomery are sebaceous glands in the areola surrounding the nipple. The glands make oily secretions (lipoid fluid) to keep the areola and the nipple lubricated and protected. Volatile compounds in these ...
- 7 Nov 2006 ... Montgomery Glands . I want to know if there is any way to get rid of montgomery glands. They are very unattractive and my husband to be doesn't seem interested in touching my breats because of them. I just want them gone.
★リンクテーブル★
[★]
- 英
- Montgomery glands, Montgomery gland, Montgomery's glands
- 同
- 乳輪腺 areolar glands glandulae areolares
- 関
- 乳房、乳輪
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