English Journal

A novel function of MUC18: amplification of lung inflammation during bacterial infection.

Wu Q, Case SR, Minor MN, Jiang D, Martin RJ, Bowler RP, Wang J, Hartney J, Karimpour-Fard A, Chu HW.SourcePulmonary Division, Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA.
The American journal of pathology.Am J Pathol.2013 Mar;182(3):819-27. doi: 10.1016/j.ajpath.2012.11.005. Epub 2012 Dec 17.
Bacterial infection plays a critical role in exacerbations of various lung diseases, including chronic pulmonary obstructive disease (COPD) and asthma. Excessive lung inflammation is a prominent feature in disease exacerbations, but the underlying mechanisms remain poorly understood. Cell surface gl
PMID 23256918

A novel model of spontaneous otitis media with effusion (OME) in the Oxgr1 knock-out mouse.

Kerschner JE, Hong W, Taylor SR, Kerschner JA, Khampang P, Wrege KC, North PE.SourceDivision of Pediatric Otolaryngology, 9000 West Wisconsin Avenue, Milwaukee, WI 53226, United States. kersch@mcw.edu
International journal of pediatric otorhinolaryngology.Int J Pediatr Otorhinolaryngol.2013 Jan;77(1):79-84. doi: 10.1016/j.ijporl.2012.09.037. Epub 2012 Nov 30.
OBJECTIVE: A novel mouse model with a specific genetic mutation in a G protein coupled receptor (GPCR) encoded by the Oxgr1 gene results in a predisposition to spontaneous otitis media with effusion. As a primary component of interest in OME, mucin expression was examined in this model to assess exp
PMID 23200873