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English Journal

Williamson DA1, Heffernan H.
The New Zealand medical journal.N Z Med J.2014 Sep 26;127(1403):41-54.
Antimicrobial resistance is one of the biggest health threats of the modern age, threatening the routine treatment of many common infectious diseases. Resistance to many common antimicrobials is now endemic in New Zealand, in both community and healthcare settings. Over the past two decades, the lan
PMID 25290498

A systematic review for pursuing the presence of antibiotic associated enterocolitis caused by methicillin resistant Staphylococcus aureus.

Iwata K1, Doi A, Fukuchi T, Ohji G, Shirota Y, Sakai T, Kagawa H.
BMC infectious diseases.BMC Infect Dis.2014 May 9;14:247. doi: 10.1186/1471-2334-14-247.
BACKGROUND: Although it has received a degree of notoriety as a cause for antibiotic-associated enterocolitis (AAE), the role of methicillin resistant Staphylococcus aureus (MRSA) in the pathogenesis of this disease remains enigmatic despite a multitude of efforts, and previous studies have failed t
PMID 24884581

Trends of Staphylococcus aureus bloodstream infections in a neonatal intensive care unit from 2000-2009.

Dolapo O1, Dhanireddy R, Talati AJ.
BMC pediatrics.BMC Pediatr.2014 May 9;14:121. doi: 10.1186/1471-2431-14-121.
BACKGROUND: Invasive methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) infections are major causes of numerous neonatal intensive care unit (NICU) outbreaks. There have been increasing reports of MRSA outbreaks in various neonatal intensive car
PMID 24886471

日本臨床外科学会雑誌 = The journal of the Japan Surgical Association 72(10), 2524-2529, 2011-10-25
NAID 10030458892

IRE.698を参考にしつつ

バンコマイシンは最後の切り札として温存すべきである。米国ではバンコマイシン使用は厳重に管理されている。日本の臨床ではどうであろうか。抗菌薬に投資開発のリソースをつぎ込んでいる企業はかつてより少なくなってきている。細菌の進化をなるべく遅くするために、抗菌薬をもっと丁寧に使わなければならない。
かつては「MRSA腸炎」と疑診しただけでバンコマイシンを使用しており、経験的治療としては正しいかも知れないが、抗菌薬の適正利用とはほど遠い。