- 関
- MRP2
- デュビン・ジョンソン症候群の発症と関連している
WordNet
- the 13th letter of the Roman alphabet (同)m
PrepTutorEJDIC
- Mach number / mark[s] / Monsieur
UpToDate Contents
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- 1. 抱合型高ビリルビン血症関連の遺伝性疾患 inherited disorders associated with conjugated hyperbilirubinemia
- 2. ビリルビン代謝 bilirubin metabolism
English Journal
- A microfluidically perfused three dimensional human liver model.
- Rennert K1, Steinborn S1, Gröger M2, Ungerböck B3, Jank AM4, Ehgartner J5, Nietzsche S6, Dinger J7, Kiehntopf M8, Funke H4, Peters FT7, Lupp A9, Gärtner C3, Mayr T5, Bauer M10, Huber O11, Mosig AS12.
- Biomaterials.Biomaterials.2015 Dec;71:119-31. doi: 10.1016/j.biomaterials.2015.08.043. Epub 2015 Aug 25.
- Within the liver, non-parenchymal cells (NPCs) are critically involved in the regulation of hepatocyte polarization and maintenance of metabolic function. We here report the establishment of a liver organoid that integrates NPCs in a vascular layer composed of endothelial cells and tissue macrophage
- PMID 26322723
- Age-related changes in mRNA levels of hepatic transporters, cytochrome P450 and UDP-glucuronosyltransferase in female rats.
- Kawase A1, Ito A, Yamada A, Iwaki M.
- European journal of drug metabolism and pharmacokinetics.Eur J Drug Metab Pharmacokinet.2015 Jun;40(2):239-44. doi: 10.1007/s13318-014-0208-7. Epub 2014 Jun 5.
- Hepatic transporters and metabolic enzymes affect drug pharmacokinetics. Limited information exists on the alteration in mRNA levels of hepatic transporters and metabolic enzymes with aging. We examined the effects of aging on the mRNA levels of representative hepatic drug transporters and metabolic
- PMID 24899460
- The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2.
- Skrypek N1,2,3, Vasseur R1,2,3, Vincent A1,2,3, Duchêne B1,2,3, Van Seuningen I1,2,3, Jonckheere N1,2,3.
- Oncotarget.Oncotarget.2015 May 10;6(13):10853-67.
- Pancreatic adenocarcinoma (PDAC) is one of the most deadly cancers because of a lack of early diagnostic markers and efficient therapeutics. The fluorinated analog of deoxycytidine, gemcitabine and emerging FOLFIRINOX protocol (5-fluorouracil (5-FU), irinotecan/SN-38, oxaliplatin and leucovorin) are
- PMID 25890497
Japanese Journal
- Comparison of the Expression and Function of ATP Binding Cassette Transporters in Caco-2 and T84 cells on Stimulation by Selected Endogenous Compounds and Xenobiotics
- NARUHASHI Kazumasa,KURAHASHI Yuko,FUJITA Yukari,KAWAKITA Eri,YAMASAKI Yuna,HATTORI Kana,NISHIMURA Asako,SHIBATA Nobuhito
- Drug Metabolism and Pharmacokinetics 26(2), 145-153, 2011
- … Caco-2 and T84 cells are intestinal epithelial model cells. … Caco-2 cells are more commonly used in drug transport studies, whereas only a few studies have used T84 cells, and the two cell lines have not been compared. …
- NAID 130004463172
- The Influence of Aged Garlic Extract on the Uptake of Saquinavir and Darunavir into HepG2 Cells and Rat Liver Slices
- BERGINC Katja,TRONTELJ Jurij,KRISTL Albin
- Drug Metabolism and Pharmacokinetics 25(3), 307-313, 2010
- … The in vitro uptake of both drugs into HepG2 cells and precision cut rat liver slices significantly increased in the presence of Pgp and MRP-2 inhibitor ritonavir. … The incubation medium containing aged garlic extract caused significant inhibition of saquinavir efflux from HepG2 cells and precision cut liver slices, while the activity of darunavir efflux transporters in both liver models significantly increased. …
- NAID 130004933491
- Compensatory Expression of MRP3 in the Livers of MRP2-Deficient EHBRs Is Promoted by DHA Intake
- Kubo Kazuhiro,Sekine Seiji,Saito Morio
- Bioscience, biotechnology, and biochemistry 73(11), 2432-2438, 2009-11-23
- … EHBRs are deficient in multidrug resistance-associated protein (MRP) 2, and show defective urinary excretion of numerous xenobiotics and organic anions. …
- NAID 10027547717
Related Links
- 実際の実務に役立つ生産管理と生産管理システムなどに 関する情報をわかりやすくまとめました。 「MRP2」です。 ... 前回、MRPについて少しお話しました。 MRPとは、Material Requirements Planningの略です。 日本語で言うと ...
- MRP2(multidrug resistance-associated protein 2, cMOAT, ABCC2)は、有機アニオン性薬物の胆汁酸排泄に働く、重要なABCトランスポーターです。 薬物の初回通過効果および体内動態に大きな影響を与えるだけではなく、腫瘍にも高い ...
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「MR」
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「MRPs」
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- multidrug resistance proteins