MODY

出典: meddic

maturity-onset diabetes of the young:


Maturity-onset diabetes in young
maturity onset diabetes in the young
maturity-onset diabetes of youth
maturity-onset diabetes of the young:


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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/18 07:13:56」(JST)

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英文文献

  • Dihydropyridine calcium channel blockers inhibit non-esterified-fatty-acid-induced endothelial and rheological dysfunction.
  • Yasu T, Kobayashi M, Mutoh A, Yamakawa K, Momomura S, Ueda S.Source*Department of Clinical Pharmacology and Therapeutics, University of the Ryukyus School of Medicine, Okinawa, Japan.
  • Clinical science (London, England : 1979).Clin Sci (Lond).2013 Sep 1;125(5):247-55. doi: 10.1042/CS20120311.
  • Circulating NEFAs (non-esterified fatty acids) from adipose tissue lipolysis lead to endothelial dysfunction and insulin resistance in patients with the metabolic syndrome or Type 2 diabetes mellitus. The aim of the present study was to test the hypothesis that DHP (dihydropyridine) CCBs (calcium c
  • PMID 23535137
  • The vascular smooth muscle cell: a therapeutic target in Type 2 diabetes?
  • Porter KE, Riches K.AbstractThe rising epidemic of T2DM (Type 2 diabetes mellitus) worldwide is of significant concern. The inherently silent nature of the disease in its early stages precludes early detection; hence cardiovascular disease is often established by the time diabetes is diagnosed. This increased cardiovascular risk leads to significant morbidity and mortality in these individuals. Progressive development of complications as a result of previous exposure to metabolic disturbances appears to leave a long-lasting impression on cells of the vasculature that is not easily reversed and is termed 'metabolic memory'. SMCs (smooth muscle cells) of blood vessel walls, through their inherent ability to switch between a contractile quiescent phenotype and an active secretory state, maintain vascular homoeostasis in health and development. This plasticity also confers SMCs with the essential capacity to adapt and remodel in pathological states. Emerging clinical and experimental studies propose that SMCs in diabetes may be functionally impaired and thus contribute to the increased incidence of macrovascular complications. Although this idea has general support, the underlying molecular mechanisms are currently unknown and hence are the subject of intense research. The aim of the present review is to explore and evaluate the current literature relating to the problem of vascular disease in T2DM and to discuss the critical role of SMCs in vascular remodelling. Possibilities for therapeutic strategies specifically at the level of T2DM SMCs, including recent novel advances in the areas of microRNAs and epigenetics, will be evaluated. Since restoring glucose control in diabetic patients has limited effect in ameliorating their cardiovascular risk, discovering alternative strategies that restrict or reverse disease progression is vital. Current research in this area will be discussed.
  • Clinical science (London, England : 1979).Clin Sci (Lond).2013 Aug 1;125(4):167-82. doi: 10.1042/CS20120413.
  • The rising epidemic of T2DM (Type 2 diabetes mellitus) worldwide is of significant concern. The inherently silent nature of the disease in its early stages precludes early detection; hence cardiovascular disease is often established by the time diabetes is diagnosed. This increased cardiovascular ri
  • PMID 23634936
  • Production and structural characterization of biosurfactant produced by an alkaliphilic bacterium, Klebsiella sp.: Evaluation of different carbon sources.
  • Jain RM, Mody K, Joshi N, Mishra A, Jha B.SourceDiscipline of Marine Biotechnology and Ecology, CSIR- Central Salt and Marine Chemicals Research Institute (CSIR- CSMCRI), G. B. Marg, Bhavnagar, Gujarat 364021, India.
  • Colloids and surfaces. B, Biointerfaces.Colloids Surf B Biointerfaces.2013 Aug 1;108:199-204. doi: 10.1016/j.colsurfb.2013.03.002. Epub 2013 Mar 14.
  • The potential of an alkaliphilic bacterium Klebsiella sp. strain RJ-03, to utilize different carbon sources for the production of an extracellular biosurfactant was evaluated. Among the several carbon substrates tested, production of the crude biosurfactant was found to be the highest with starch (1
  • PMID 23545089

和文文献

  • 症例報告 尿管自然破裂を合併したmaturity-onset of the diabetes of the young (MODY) 5の1例
  • 堀 賢一郎,麻生 好正,寺沢 智子 [他]
  • 糖尿病 56(11), 849-855, 2013-11
  • NAID 40019898456
  • 臨床研究・症例報告 小児健康診査を契機に高血糖を指摘され遺伝子解析によりMODY2と診断された父児例
  • 森谷 邦彦,鈴木 淳美,鈴木 大 [他]
  • 小児科臨床 66(8), 1781-1784, 2013-08
  • NAID 40019701304
  • MODY原因遺伝子の現状と診断の進め方 (AYUMI 糖尿病の疾患感受性遺伝子Update)
  • 岩﨑 直子,滝澤 美保,井出 理沙 [他]
  • 医学のあゆみ 244(12), 1030-1034, 2013-03-23
  • NAID 40019612231

関連リンク

概要. メンデル遺伝様式(常染色体優性)で発症する若年糖尿病であり(通常 25歳以下 の発症)、現在までに6種類の原因遺伝子が同定されています(MODY1-6)。MODYは 非肥満のインスリン分泌不全を特徴とし、2型糖尿病 でみられるインスリン抵抗性は 原則 ...
2010年11月18日 ... 概要. 若年(通常25歳未満)で診断され、肥満がなく、親や兄弟に糖尿病が認められる 場合にはMODYというタイプの糖尿病が疑われる。MODYは一見したところ2型糖尿病 や1型糖尿病と何ら変わるところはないため、診断までは通常の1型 ...

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★リンクテーブル★
リンク元若年発症型成人型糖尿病」「adult-onset diabetes mellitus」「maturity-onset diabetes mellitus」「maturity-onset diabetes of the young」「若年発症成人型糖尿病
関連記事MO

若年発症型成人型糖尿病」

  [★]

maturity-onset diabetes of the youngMODY
インシュリン非依存性糖尿病II型糖尿病2型糖尿病若年成人発症型糖尿病成人発症型糖尿病若年発症成人型糖尿病


adult-onset diabetes mellitus」

  [★]

成人発症型糖尿病

maturity-onset diabetesmaturity-onset diabetes mellitusMODYNIDDMnon-insulin-dependent diabetes mellitustype 2 diabetes mellitustype II diabetes mellitus

maturity-onset diabetes mellitus」

  [★]

成人発症型糖尿病

adult-onset diabetes mellitusmaturity-onset diabetesMODYNIDDMnon-insulin-dependent diabetes mellitustype 2 diabetes mellitustype II diabetes mellitus


maturity-onset diabetes of the young」

  [★] 若年発症成人型糖尿病

MODY
MODY
MODY
MODY


若年発症成人型糖尿病」

  [★]

maturity-onset diabetes of the youngMODY
若年発症型成人型糖尿病若年成人発症型糖尿病


MO」

  [★] 僧帽弁開口部 mitral valve ostium

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