PrepTutorEJDIC
- Michigan / Military Intelligence 陸軍情報部
English Journal
- 2009 H1N1 vaccination in Minnesota: an evaluation by ZIP code.
- Muscoplat MH1, Roddy M1, Parilla E1, Davey CS2, Fleege L1, White K1, Ehresmann K1.Author information 1Minnesota Department of Health, MN, USA.2Biostatistical Design and Analysis Center, University of Minnesota, MN, USA.AbstractAccording to Minnesota Immunization Information Connection (MIIC) data, 23% of Minnesotans were vaccinated against 2009 pandemic H1N1 influenza. We analyzed 2009 H1N1 vaccination data at the ZIP code level to learn more about who received the vaccine between 2009 and 2010. We found significant differences in H1N1 vaccination rates by percentage of residents living below the family poverty line, percentage of non-Caucasian residents in a ZIP code and median family income. When stratified by urban or rural location, median family income was significantly associated with vaccination rate only in urban settings; the percentage of non-Caucasians living in an area was significant only in rural settings. In both urban and rural settings, most H1N1 vaccinations were given in a private facility, although the proportion was much higher in urban ZIP codes (81.5%) than rural ZIP codes (53.2%, P < 0.0001). Further research is needed to find out why vaccination rates were associated with increasing median family income in urban areas and why in rural areas, people living in ZIP codes with a higher percentage of non-Caucasian residents were more likely to be vaccinated after controlling for poverty and median income.
- Minnesota medicine.Minn Med.2013 Sep;96(9):49-54.
- According to Minnesota Immunization Information Connection (MIIC) data, 23% of Minnesotans were vaccinated against 2009 pandemic H1N1 influenza. We analyzed 2009 H1N1 vaccination data at the ZIP code level to learn more about who received the vaccine between 2009 and 2010. We found significant diffe
- PMID 24494363
- How to target MHC class II into the MIIC compartment.
- Garstka MA1, Neefjes J.Author information 1Netherlands Cancer Institute, Amsterdam, The Netherlands. m.garstka@nki.nlAbstractMajor histocompatibility complex (MHC) class II molecules (MHC II) present exogenous antigens to CD4+ T cells to modulate immune responses. To contact these antigens, MHC II is delivered to the late endosomal MHC class II compartment (MIIC). This compartment has a complex architecture and consists of internal membranes or vesicles surrounded by a limiting membrane. These subdomains have different protein and lipid content. Also MHC II peptide loading is spatially organized in MIIC as it interacts with DM on intralumenal vesicles (ILVs) to bind antigen. How this is controlled is only understood in a sketchy manner. This may involve ubiquitin modification of MHC II, possibly by E3 ligases of the March family. But other proteins are likely involved as well including E3 ligases, deubiquitylating enzymes (DUBs), adaptor, scaffold, motor and vesicular coat proteins. Our lab performed a genome-wide siRNA screen to define novel proteins and pathways involved in MHC II antigen presentation. The data set is used to select candidate proteins involved in targeting MHC II into MIIC. This process involves ubiquitin modifications and various new molecules not considered as yet in this complex pathway. These molecules may be targeted by drugs to manipulate MHC II responses in auto-immunity, transplantation and other disease states.
- Molecular immunology.Mol Immunol.2013 Sep;55(2):162-5. doi: 10.1016/j.molimm.2012.10.022. Epub 2012 Nov 27.
- Major histocompatibility complex (MHC) class II molecules (MHC II) present exogenous antigens to CD4+ T cells to modulate immune responses. To contact these antigens, MHC II is delivered to the late endosomal MHC class II compartment (MIIC). This compartment has a complex architecture and consists o
- PMID 23200228
Japanese Journal
- Ultrastructure of immature and mature human oocytes after cryotop vitrification
- Ultrastructure of Immature and Mature Human Oocytes after Cryotop Vitrification
- MHC class II compartment, endocytosis and phagocytic activity of macrophages and putative dendritic cells isolated from normal tissues rich in synovium
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