- 同
- CIITA
- 同
- CIITA
WordNet
- elegance in dress or behavior; "she has a lot of class"
- a collection of things sharing a common attribute; "there are two classes of detergents" (同)category, family
- a league ranked by quality; "he played baseball in class D for two years"; "Princeton is in the NCAA Division 1-AA" (同)division
- a body of students who are taught together; "early morning classes are always sleepy" (同)form, grade, course
- people having the same social, economic, or educational status; "the working class"; "an emerging professional class" (同)stratum, social_class, socio-economic class
- a body of students who graduate together; "the class of 97"; "she was in my year at Hoehandle High" (同)year
- (biology) a taxonomic group containing one or more orders
- the 9th letter of the Roman alphabet (同)i
- the 13th letter of the Roman alphabet (同)m
PrepTutorEJDIC
- 〈C〉(何らかの類似性を持つ)(…の)『種類』,類(sort, kind)《+『of』+『名』》 / 〈C〉《集合的に》《単数扱い》『クラス』,学級,組 / 〈U〉〈C〉(クラス単位の)『授業』;授業時間 / 〈C〉《米》《集合的に》(主に高校・大学の)同期生 / 〈C〉《しばしば複数形で》(同程度の教育・経済力・社会的地位などを持つ)『階級』,階層 / 〈C〉(交通機関などの)『等級』 / 〈C〉(英国の大学の)試験の合格等級 / 〈C〉綱(こう)(動植物の分類で門(phylum, division)と目(もく)(order)の間) / 〈U〉《話》(その人の社会的地位を高く見せる)風格 / …'を'(…の)部類に入れる《+『名』+『among』(『with』)+『名』》,(…として)…'を'分類する《+『名』+『as』+『名』》
- 『私は』私が
- iodineの化学記号
- Mach number / mark[s] / Monsieur
UpToDate Contents
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- 1. ヒト白血球抗原（HLA）：ロードマップ human leukocyte antigens hla a roadmap
- 2. 主要組織適合性複合体（MHC）の構造および機能 major histocompatibility complex mhc structure and function
- 3. 腎移植におけるHLAマッチングと移植片生着率 hla matching and graft survival in kidney transplantation
- 4. 免疫不全症を引き起こすCD3／T細胞受容体複合体疾患 cd3 t cell receptor complex disorders causing immunodeficiency
- 5. 関節リウマチにおけるHLAおよびその他の感受性遺伝子 hla and other susceptibility genes in rheumatoid arthritis
English Journal
- CIITA: A Master Regulator of Adaptive Immunity Shows its Innate Side in the Bone.
- Nakamura MC.Author information Department of Medicine, Division of Rheumatology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA, 94143; Arthritis/Immunology Section, Veterans Affairs Medical Center, 4150 Clement Street, 111R, San Francisco, CA, 94121.AbstractCIITA (the Major Histocompatibility Class (MHC) II transactivator) has long been known as the master regulator of MHC Class II genes, which are critical for normal immune function (reviewed in (1, 2)). CIITA is a non-DNA binding co-activator that specifically regulates expression of Major Histocompatibility Class II molecules, with CIITA deficiency leading to the rare human immunodeficiency disease termed Bare Lymphocyte Syndrome (3). CIITA also regulates expression of genes encoding accessory proteins required for MHCII-restricted antigen presentation, thus CIITA is central to controlling the response to foreign antigens and the maintenance of tolerance (1, 2). © 2013 American Society for Bone and Mineral Research.
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.J Bone Miner Res.2013 Dec 17. doi: 10.1002/jbmr.2161. [Epub ahead of print]
- CIITA (the Major Histocompatibility Class (MHC) II transactivator) has long been known as the master regulator of MHC Class II genes, which are critical for normal immune function (reviewed in (1, 2)). CIITA is a non-DNA binding co-activator that specifically regulates expression of Major Histocompa
- PMID 24343972
- Epigenetic modulation of RFC1, MHC2TA and HLA-DR in systemic lupus erythematosus: Association with serological markers and six functional polymorphisms of one-carbon metabolic pathway.
- Rupasree Y1, Naushad SM2, Rajasekhar L3, Kutala VK4.Author information 1Department of Clinical Pharmacology & Therapeutics, Nizam's Institute of Medical Sciences (NIMS), Hyderabad 500082, India.2School of Chemical & Biotechnology, SASTRA University, Tirumalaisamudram, Thanjavur 613401, India.3Department of Rheumatology, Nizam's Institute of Medical Sciences (NIMS), Hyderabad 500082, India.4Department of Clinical Pharmacology & Therapeutics, Nizam's Institute of Medical Sciences (NIMS), Hyderabad 500082, India. Electronic address: vijaykutala@gmail.com.AbstractThe current study was conducted to elucidate the effect of genetic variations in one-carbon metabolism on the epigenetic regulation of major histocompatibility complex II transactivator (MHC2TA), reduced folate carrier 1 (RFC1/SLC19A1) and human leukocyte antigen (HLA)-DR in systemic lupus erythematosus (SLE). PCR-RFLP/AFLP, bisulfite-sequencing and real-time PCR approaches were used for genetic, epigenetic and expression analysis respectively. SLE cases exhibited elevated plasma homocysteine levels compared to healthy controls (24.93±1.3 vs. 11.67±0.48μmol/l), while plasma folate levels showed no association (7.10±2.49 vs. 7.64±2.09ng/ml). The RFC1 80G>A polymorphism showed 1.32-fold risk (95% CI: 1.02-1.72) for SLE, while glutamate carboxypeptidase II (GCPII) 1561C>T showed reduced risk (OR: 0.47, 95% CI: 0.24-0.90). The expression of RFC1 (0.37±0.09 vs. 0.60±0.17) and HLA-DR (0.68±0.17 vs. 0.98±0.02) was down regulated in the SLE cases. The hypermethylation of RFC1 as observed in the current study may contribute for its down regulation. Plasma folate and thymidylate synthase (TYMS) 5'-UTR 28bp tandem repeat showed an inverse association with methylation of RFC1 and MHC2TA. SLE cases with hypocomplementemia showed hypermethylation of RFC1, hypomethylation/up regulation of MHC2TA and down regulation of HLA-DR. The hypermethylation of MHC2TA and down regulation of RFC1, MHC2TA and HLA-DR were observed in anti-cardiolipin antibody positive SLE cases. The up regulation of RFC1 and HLA-DR was observed in anti-dsDNA antibody positive SLE cases. The hypomethylation/upregulation of RFC1 and MHC2TA was observed in anti-RNP antibody positive cases. To conclude, one-carbon genetic variants influence epigenetic of MHC2TA and RFC1, thus contributing to phenotypic heterogeneity of SLE.
- Gene.Gene.2013 Dec 12. pii: S0378-1119(13)01620-X. doi: 10.1016/j.gene.2013.11.094. [Epub ahead of print]
- The current study was conducted to elucidate the effect of genetic variations in one-carbon metabolism on the epigenetic regulation of major histocompatibility complex II transactivator (MHC2TA), reduced folate carrier 1 (RFC1/SLC19A1) and human leukocyte antigen (HLA)-DR in systemic lupus erythemat
- PMID 24333266
- Functionally distinct gene classes as bigger or smaller transcription factor traps: A possible stochastic component to sequential gene expression programs in cancer.
- Mauro JA, Blanck G.Author information Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, United States.AbstractIn cancer biology, most molecular regulatory mechanisms are casually treated as on/off switches for specific cancer hallmarks, despite the lack of compelling evidence that cancer hallmarks can be exclusively attributed to specific regulatory proteins. To consider a novel paradigm for the basis of regulating a set of effector genes for proliferation, versus apoptosis-effector genes, we used a bioinformatics approach to ascertain differences between the transcription factor binding site occurrences in the two sets of genes. Results indicated that there are more binding sites per gene, for transcription factors that regulate both proliferation and apoptosis, among the proliferation-effector genes than among the apoptosis-effector genes. Proliferation-effector genes also had more open chromatin regions. We also applied this paradigm to the question of why p53 and interferon regulatory factor-1 (IRF-1) first activate cell cycle arrest genes followed by apoptosis genes, with results indicating the cycle arrest genes are bigger p53 and IRF-1 traps. These data support the idea that, as a set of transcription factors becomes active, there is a stochastic component leading to the accumulation of these transcription factors on genes that effect an initial phenotype before their accumulation on genes that effect a subsequent phenotype.
- Gene.Gene.2013 Nov 27. pii: S0378-1119(13)01538-2. doi: 10.1016/j.gene.2013.11.013. [Epub ahead of print]
- In cancer biology, most molecular regulatory mechanisms are casually treated as on/off switches for specific cancer hallmarks, despite the lack of compelling evidence that cancer hallmarks can be exclusively attributed to specific regulatory proteins. To consider a novel paradigm for the basis of re
- PMID 24291030
Japanese Journal
- Enhanced production of p24 Gag protein in HIV-1-infected rat cells fused with uninfected human cells.
- Chen Jing,Zhao Xudong,Lai Yurong,Suzuki Akira,Tomaru Utano,Ishizu Akihiro,Takada Akio,Ikeda Hitoshi,Kasahara Masanori,Yoshiki Takashi
- Experimental and Molecular Pathology 83(1), 125-130, 2007-08
- … The results suggested that HP68 and MHC class II transactivator (CIITA) might up- and down-regulate p24 production, respectively. …
- NAID 120000965328
- Tumor cells transduced with the MHC class II transactivator and CD80 activate tumor-specific CD4+ T cells whether or not they are silenced for invariant chain
- THOMPSON J. A.
- Cancer Res. 66, 1147, 2006
- NAID 30018587729
- ヒトCD4, CCR5, MHC class II transactivator を発現するトランスジェニックラットの作製と末梢血単核球へのHIV-1の感染
- 鈴木 昭
- 北海道醫學雜誌 = Acta medica Hokkaidonensia 80(6), 555-563, 2005-11-01
- NAID 10029918798
Related Links
- Gene provides a unified query environment for genes defined by sequence and/or in NCBI's Map Viewer. ... Gene ID: 12265, updated on 29-Sep-2013 Summary Other designations MHC class II transactivator GeneRIFs: Gene ...
- Mojun Zhao, a Frederick L. Flynt, a Mei Hong, a Han Chen, a Carolyn A. Gilbert, a Nicole T. Briley, a Sophia C. Bolick, b Kenneth L. Wright, b and Janet F. Piskurich a* ... The MHC Class II transactivator (CIITA) acts in the cell ...
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| 関連記事 | 「class」「II」「I」「MHC class」「MH」 |
「class」
- n.
- 関
- assortment、branch、categorization、categorize、category、classification、classifier、classify、department、division、group、grouping、kind、pattern、section、sector、sort、systematization、typing
「II」
「I」