WordNet
- (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
- the 13th letter of the Roman alphabet (同)m
- informal term for information; "give me the gen on your new line of computers"
PrepTutorEJDIC
- 遺伝子
- Mach number / mark[s] / Monsieur
UpToDate Contents
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- 1. 急性骨髄性白血病の予後 prognosis of acute myeloid leukemia
- 2. 原発性免疫不全症に対する遺伝子治療 gene therapy for primary immunodeficiency
- 3. 肥満の病因 pathogenesis of obesity
- 4. 大腸癌の分子遺伝学 molecular genetics of colorectal cancer
- 5. 拡張型心筋症の遺伝学 genetics of dilated cardiomyopathy
English Journal
- Pituitary homeobox 2 (PITX2) protects renal cancer cell lines against doxorubicin toxicity by transcriptional activation of the multidrug transporter ABCB1.
- Lee WK, Chakraborty PK, Thévenod F.SourceInstitute of Physiology and Pathophysiology, ZBAF, Witten/Herdecke University, Witten, North-Rhine Westphalia, Germany.
- International journal of cancer. Journal international du cancer.Int J Cancer.2013 Aug 1;133(3):556-67. doi: 10.1002/ijc.28060. Epub 2013 Feb 27.
- The multidrug resistance (MDR) P-glycoprotein ABCB1 plays a major role in MDR of malignant cells and is regulated by various transcription factors, including Wnt/β-catenin/TCF4. The transcription factor PITX2 (Pituitary homeobox-2) is essential for embryonic development. PITX2 operates by recruitin
- PMID 23354914
- Down-regulation of c-fos by shRNA sensitizes adriamycin-resistant MCF-7/ADR cells to chemotherapeutic agents via P-glycoprotein inhibition and apoptosis augmentation.
- Shi R, Peng H, Yuan X, Zhang X, Zhang Y, Fan D, Liu X, Xiong D.SourceDepartment of Pharmacology, Shanxi Medical University, Shanxi 030001, China.
- Journal of cellular biochemistry.J Cell Biochem.2013 Aug;114(8):1890-900. doi: 10.1002/jcb.24533.
- Multidrug resistance (MDR) is a major hurdle in the treatment of cancer. Research indicated that the main mechanisms of most cancers included so-called "pump" (P-glycoprotein, P-gp) and "non-pump" (apoptosis) resistance. Identification of novel signaling molecules associated with both P-gp and apopt
- PMID 23494858
Japanese Journal
- Antimicrobial resistance of Escherichia coli isolates from canine urinary tract infections
- CHANG Shao-Kuang,LO Dan-Yuan,WEI Hen-Wei [他],KUO Hung-Chih
- Journal of Veterinary Medical Science 77(1), 59-65, 2015
- … Among the resistant isolates, 17 resistance patterns were observed, with 12 patterns involving multidrug resistance (MDR). … Class 1 integrons were prevalent (28.9%) and contained previously described gene cassettes that are implicated primarily in resistance to aminoglycosides and trimethoprim (dfrA1, dfrA17-aadA5). …
- NAID 130004781020
- Antimicrobial resistance of Escherichia coli isolates from canine urinary tract infections
- CHANG Shao-Kuang,LO Dan-Yuan,WEI Hen-Wei,KUO Hung-Chih
- Journal of Veterinary Medical Science, 2014
- … Among the resistant isolates, 17 resistance patterns were observed, with 12 patterns involving multidrug resistance (MDR). … Class 1 integrons were prevalent (28.9%) and contained previously described gene cassettes that are implicated primarily in resistance to aminoglycosides and trimethoprim (dfrA1, dfrA17-aadA5). …
- NAID 130004701592
- Involvement of AP-1 and NF-κB in the Up-regulation of P-gp in Vinblastine Resistant Caco-2 Cells
- CHEN Qiuxia,BIAN Yicong,ZENG Su
- Drug Metabolism and Pharmacokinetics 29(2), 223-226, 2014
- … Caco-2 is a widely used cell model in drug absorption and P-glycoprotein (P-gp, MDR1) substrate identification. … Since vinblastine is the inducer of both activator protein-1 (AP-1) and nuclear factor kappa B (NF-κB), we investigated the role of AP-1 and NF-κB in the regulation of MDR1 gene expression. … Our results indicated that the AP-1 and NF-κB luciferase activity was higher in Caco-2 vbl cells than that in Caco-2 cells according to reporter gene assay. …
- NAID 130004463373
Related Links
- mdr-1 gene multi-drug resistance gene; normally responsible for maintaining the blood-brain barrier to certain drugs. A deletion mutation in this gene is responsible for the sensitivity to ivermectin observed in Collie dogs and related ...
- Research Topics, Publications, Research Grants, Scientific Experts, Genomes and Genes, Species about mdr genes ... You are here: Research Topics > physical sciences > .. > .. > genome components > genes > mdr genes
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★リンクテーブル★
| リンク元 | 「多剤耐性遺伝子」「MDR遺伝子」「multidrug resistance gene」 |
| 関連記事 | 「MD」「M」 |
「多剤耐性遺伝子」
「MDR遺伝子」
「multidrug resistance gene」
- 関
- MDR gene
「MD」
- 医学博士 medical doctor
- 維持量 maintenance dose
- 筋ジストロフィー muscular dystrophy
- 筋強直性ジストロフィー myotonic dystrophy
- 視床背内側核 dorsomedial nucleus mediodorsal thalamic nucleus
- 平均偏差 mean deviation
- MD双胎 一絨毛膜二羊膜双胎 monochorionic diamniotic twin