MAP kinase kinase 6

• MAPキナーゼキナーゼ6

関

mitogen-activated protein kinase kinase 6

WordNet

1. make a map of; show or establish the features of details of; "map the surface of Venus"
2. to establish a mapping (of mathematical elements or sets) (同)represent
3. a diagrammatic representation of the earths surface (or part of it)
4. plan, delineate, or arrange in detail; "map ones future" (同)map out
5. depict as if on a map; "sorrow was mapped on the mothers face"
6. explore or survey for the purpose of making a map; "We havent even begun to map the many galaxies that we know exist"
7. locate within a specific region of a chromosome in relation to known DNA or gene sequences; "map the genes"
8. the 13th letter of the Roman alphabet (同)m
9. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme

PrepTutorEJDIC

1. (1枚1枚の)『地図』;天体図 / …‘の'地図を作る;…‘を'地図にかく
2. Mach number / mark[s] / Monsieur
3. Massachusetts / mental age

UpToDate Contents

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• 1. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
• 2. 前立腺癌の分子生物学 molecular biology of prostate cancer
• 3. 黒色腫（メラノーマ）の分子生物学 the molecular biology of melanoma
• 4. レフルノミドによる関節リウマチの治療 leflunomide in the treatment of rheumatoid arthritis
• 5. 進行非小細胞肺癌に対する遺伝子型による個別治療 personalized genotype directed therapy for advanced non small cell lung cancer

English Journal

• Fragment-based drug discovery of potent and selective MKK3/6 inhibitors.

• Adams M1, Kobayashi T2, Lawson JD3, Saitoh M2, Shimokawa K2, Bigi SV1, Hixon MS4, Smith CR1, Tatamiya T2, Goto M2, Russo J5, Grimshaw CE3, Swann S1.
• Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2016 Feb 1;26(3):1086-9. doi: 10.1016/j.bmcl.2015.11.054. Epub 2015 Nov 17.
• The MAPK signaling cascade, comprised of several linear and intersecting pathways, propagates signaling into the nucleus resulting in cytokine and chemokine release. The Map Kinase Kinase isoforms 3 and 6 (MKK3 and MKK6) are responsible for the phosphorylation and activation of p38, and are hypothes
• PMID 26704264

• Two hydrophobic residues can determine the specificity of mitogen-activated protein kinase docking interactions.

• Bardwell AJ1, Bardwell L2.
• The Journal of biological chemistry.J Biol Chem.2015 Oct 30;290(44):26661-74. doi: 10.1074/jbc.M115.691436. Epub 2015 Sep 14.
• MAPKs bind to many of their upstream regulators and downstream substrates via a short docking motif (the D-site) on their binding partner. MAPKs that are in different families (e.g. ERK, JNK, and p38) can bind selectively to D-sites in their authentic substrates and regulators while discriminating a
• PMID 26370088

• Overexpression of prohibitin-1 inhibits RANKL-induced activation of p38-Elk-1-SRE signaling axis blocking MKK6 activity.

• Lee CH1, Choi SW2, Kim JY3, Kim SH2, Yoon KH4, Oh J5, Lee MS6.
• Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Aug 7;463(4):1028-33. doi: 10.1016/j.bbrc.2015.06.053. Epub 2015 Jun 12.
• Prohibitin-1 (PHB) regulates diverse cellular processes by controlling several signaling pathways. In this study, we investigated the functional involvement of PHB in osteoclast differentiation. PHB expression was time-dependently increased by RANKL in BMMs. However, the retroviral over-expression o
• PMID 26079882

Japanese Journal

• Macrophage-stimulating activities of newly isolated complex polysaccharides from Parachlorella kessleri strain KNK-A001

• International Journal of Biological Macromolecules 104, 400-406, 2017-11
• NAID 120006318835

• BMP7 dose‐dependently stimulates proliferation and cadherin‐11 expression via ERK and p38 in a murine metanephric mesenchymal cell line

• Physiological Reports 5(16), e13378, 2017-09
• NAID 120006349357

• Antagonistic Interactions between Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and Retinoic Acid Receptor Signaling in Colorectal Cancer Cells

• Molecular and Cellular Biology 37(15), 2017-08
• NAID 120006334857

Related Links

• WikiGenes - Map2k6 - mitogen-activated protein kinase kinase 6

Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen- activated protein kinase [4]. ... Moreover, we show that the MKK6 mRNA is more stable in p38alpha(-/-) cells and that the 3'untranslated region of this mRNA can ...

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★リンクテーブル★

リンク元	「MAPキナーゼキナーゼ6」「mitogen-activated protein kinase kinase 6」
関連記事	「map」「MAP」「MA」「kinase」「M」

「MAPキナーゼキナーゼ6」

　　[★]

英

MAP kinase kinase 6

関

マイトジェン活性化プロテインキナーゼキナーゼ6

「mitogen-activated protein kinase kinase 6」

　　[★]

マイトジェン活性化プロテインキナーゼキナーゼ6

関

MAP kinase kinase 6

「map」

　　[★]

• n.

• 地図、マップ

• v.

• 地図で表す、(遺伝子などを)位置づける、(遺伝子などが)位置する

関

lie、locate、location、loci、locus、mapping、position、rank、sit、situated、situation、stand、topo

　 　 　 　 　 　 　 　

「MAP」

　　[★]

• 僧帽弁輪形成術 mitral annuloplasty
• Miller assessment for Pre-schoolers
• 平均動脈圧 mean arterial pressure
• 平均気道内圧 mean airway pressure
• mannitol adenine phosphate
• リン酸アンモニウムマグネシウム magnesium ammonium phosphate

「MA」

　　[★]

• 僧帽弁閉鎖症 僧帽弁閉鎖 mitral atresia
• 僧帽弁輪 mitral annulus

　

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase 　

「M」

　　[★] メチオニン methionine