MAP kinase kinase 1

• MAPキナーゼキナーゼ1

関

MAPK-ERK kinase 1、MEK1、mitogen-activated protein kinase kinase 1

WordNet

1. make a map of; show or establish the features of details of; "map the surface of Venus"
2. to establish a mapping (of mathematical elements or sets) (同)represent
3. a diagrammatic representation of the earths surface (or part of it)
4. plan, delineate, or arrange in detail; "map ones future" (同)map out
5. depict as if on a map; "sorrow was mapped on the mothers face"
6. explore or survey for the purpose of making a map; "We havent even begun to map the many galaxies that we know exist"
7. locate within a specific region of a chromosome in relation to known DNA or gene sequences; "map the genes"
8. the 13th letter of the Roman alphabet (同)m
9. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme

PrepTutorEJDIC

1. (1枚1枚の)『地図』;天体図 / …‘の'地図を作る;…‘を'地図にかく
2. Mach number / mark[s] / Monsieur
3. Massachusetts / mental age

UpToDate Contents

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• 1. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
• 2. 炭疽菌の微生物学、病因、および疫学 microbiology pathogenesis and epidemiology of anthrax
• 3. 喘息における吸入ステロイドの分子学的影響 molecular effects of inhaled glucocorticoid therapy in asthma
• 4. 進行非小細胞肺癌に対する遺伝子型による個別治療 personalized genotype directed therapy for advanced non small cell lung cancer
• 5. インスリン様成長因子Iの生理学 physiology of insulin like growth factor 1

English Journal

• Expression of pEGFR and pAKT as response-predictive biomarkers for RAS wild-type patients to anti-EGFR monoclonal antibodies in metastatic colorectal cancers.

• Harlé A1, Salleron J2, Perkins G3, Pilati C3, Blons H3, Laurent-Puig P3, Merlin JL1.
• British journal of cancer.Br J Cancer.2015 Aug 11;113(4):680-5. doi: 10.1038/bjc.2015.250. Epub 2015 Jul 14.
• BACKGROUND: RAS wild-type (RASw/t) tumours have been associated with better outcomes in patients with metastatic colorectal cancer (mCRC) treated with anti-EGFR monoclonal antibodies (mAb). We investigated the expression of EGFR downstream proteins under their active phosphorylated forms as potentia
• PMID 26171935

• Addicted to AA (Acetoacetate): A Point of Convergence between Metabolism and BRAF Signaling.

• Trousil S1, Zheng B2.
• Molecular cell.Mol Cell.2015 Aug 6;59(3):333-4. doi: 10.1016/j.molcel.2015.07.024.
• In this issue Kang et al. (2015) show that oncogenic BRAF(V600E) stimulates expression of ketogenic enzyme 3-hydroxy-3-methylglutaryl-CoA lyase and promotes the formation of the ketone body acetoacetate, which subsequently enhances BRAF(V600E)/MEK/ERK signaling.Copyright © 2015 Elsevier Inc. All ri
• PMID 26253025

• Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling.

• Kang HB1, Fan J1, Lin R1, Elf S1, Ji Q2, Zhao L1, Jin L1, Seo JH1, Shan C1, Arbiser JL3, Cohen C4, Brat D4, Miziorko HM5, Kim E6, Abdel-Wahab O6, Merghoub T6, Fröhling S7, Scholl C8, Tamayo P9, Barbie DA9, Zhou L10, Pollack BP3, Fisher K4, Kudchadkar RR1, Lawson DH1, Sica G1, Rossi M1, Lonial S1, Khoury HJ1, Khuri FR1, Lee BH11, Boggon TJ12, He C2, Kang S13, Chen J14.
• Molecular cell.Mol Cell.2015 Aug 6;59(3):345-58. doi: 10.1016/j.molcel.2015.05.037. Epub 2015 Jul 2.
• Many human cancers share similar metabolic alterations, including the Warburg effect. However, it remains unclear whether oncogene-specific metabolic alterations are required for tumor development. Here we demonstrate a "synthetic lethal" interaction between oncogenic BRAF V600E and a ketogenic enzy
• PMID 26145173

Japanese Journal

• Keratinocyte wound healing activity of galactoglycerolipids from the fern Ophioglossum vulgatum L.

• Clericuzio Marco,Burlando Bruno,Gandini Giulio [他]
• Journal of natural medicines 68(1), 31-37, 2014
• NAID 40019919732

• Astragaloside IV Inhibits Doxorubicin-Induced Cardiomyocyte Apoptosis Mediated by Mitochondrial Apoptotic Pathway via Activating the PI3K/Akt Pathway

• Jia Yuanyuan,Zuo Daiying,Li Zengqiang,Liu Hanmo,Dai Zhengning,Cai Jiayi,Pang Lili,Wu Yingliang
• Chemical and Pharmaceutical Bulletin 62(1), 45-53, 2014
• … Furthermore, AS-IV substantially reduced the mitochondrial reactive oxygen species (ROS) production and lactate dehydrogenase (LDH), creatine kinase-MB isoenzyme (CK-MB) and cytochrome c (CytC) release, and restored the reduced ATP level, succinate dehydrogenase (SDH) and ATP synthase activities induced by DOX, suggesting that AS-IV significantly attenuated DOX-induced mitochondrial damage and dysfunction. …
• NAID 130003381803

• 病原菌エフェクターによるPAMPs誘導抵抗性の抑制機構

• 川崎 努,山口 公志,石川 和也 [他]
• 日本植物病理学会報 79(4), 263-268, 2013-11
• NAID 40019895381

Related Links

• MAP kinase kinase 1 - definition of MAP kinase kinase 1 in ...

MAP2K1 MAP2K1 A gene on chromosome 15q22.1-q22.33 that encodes a dual-specificity protein kinase which is an essential component of the MAP-kinase signal transduction pathway. MAP2K1 binds to extracellular ligands (e.g ...

• MAP kinase 1 - definition of MAP kinase 1 in the Medical ...

MAPK1 MAPK1 A gene on chromosome 22q11.2|22q11.21 that encodes a protein of the MAP kinase family. MAP kinases (e.g., extracellular signal-regulated kinases) integrate multiple biochemical signals, and are involved in cell ...

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★リンクテーブル★

リンク元	「MAPキナーゼキナーゼ1」「MEK1」「MAPK-ERK kinase 1」「mitogen-activated protein kinase kinase 1」
関連記事	「map」「MAP」「MA」「kinase」「M」

「MAPキナーゼキナーゼ1」

　　[★]

英

MAP kinase kinase 1、MAPK-ERK kinase 1、MEK1

関

MAPK-ERKキナーゼ1、マイトジェン活性化プロテインキナーゼキナーゼ1

「MEK1」

　　[★]

• MAPK-ERKキナーゼ1、MAPキナーゼキナーゼ1

関

MAP kinase kinase 1、MAPK-ERK kinase 1

「MAPK-ERK kinase 1」

　　[★]

• MAPK-ERKキナーゼ1、MAPキナーゼキナーゼ1

関

MAP kinase kinase 1、MEK1

「mitogen-activated protein kinase kinase 1」

　　[★]

マイトジェン活性化プロテインキナーゼキナーゼ1

関

MAP kinase kinase 1

「map」

　　[★]

• n.

• 地図、マップ

• v.

• 地図で表す、(遺伝子などを)位置づける、(遺伝子などが)位置する

関

lie、locate、location、loci、locus、mapping、position、rank、sit、situated、situation、stand、topo

　 　 　 　 　 　 　 　

「MAP」

　　[★]

• 僧帽弁輪形成術 mitral annuloplasty
• Miller assessment for Pre-schoolers
• 平均動脈圧 mean arterial pressure
• 平均気道内圧 mean airway pressure
• mannitol adenine phosphate
• リン酸アンモニウムマグネシウム magnesium ammonium phosphate

「MA」

　　[★]

• 僧帽弁閉鎖症 僧帽弁閉鎖 mitral atresia
• 僧帽弁輪 mitral annulus

　

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase 　

「M」

　　[★] メチオニン methionine