WordNet
- an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
PrepTutorEJDIC
- Massachusetts / mental age
UpToDate Contents
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- 1. 黒色腫（メラノーマ）の分子生物学 the molecular biology of melanoma
- 2. 前立腺癌の分子生物学 molecular biology of prostate cancer
- 3. 進行非小細胞肺癌に対する遺伝子型による個別治療 personalized genotype directed therapy for advanced non small cell lung cancer
- 4. 進行性肝細胞癌に対する全身治療 systemic treatment for advanced hepatocellular carcinoma
- 5. 虚血プレコンディショニングの定義および病因 definition and pathogenesis of ischemic preconditioning
English Journal
- Protoapigenone, a natural derivative of apigenin, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of glutathione S-transferase π.
- Chen WY, Hsieh YA, Tsai CI, Kang YF, Chang FR, Wu YC, Wu CC.SourceSchool of Medicine and Health Sciences, Fooyin University, Kaohsiung, 83101, Taiwan.
- Investigational new drugs.Invest New Drugs.2011 Dec;29(6):1347-59. Epub 2010 Aug 5.
- Protoapigenone, a natural derivative of the flavonoid apigenin, has been shown to exhibit potent antitumor activity in vitro and in vivo; the precise mechanism of action, however, is not fully elucidated. In this study, we investigated and compared the mechanisms by which protoapigenone and apigenin
- PMID 20686818
- Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells.
- Aksamitiene E, Achanta S, Kolch W, Kholodenko BN, Hoek JB, Kiyatkin A.SourceDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St., Philadelphia, Pennsylvania 19107, USA.
- Cellular signalling.Cell Signal.2011 Nov;23(11):1794-805. Epub 2011 Jun 25.
- There is strong evidence that deregulation of prolactin (PRL) signaling contributes to pathogenesis and chemoresistance of breast cancer. Therefore, understanding cross-talk between distinct signal transduction pathways triggered by activation of the prolactin receptor (PRL-R), is essential for eluc
- PMID 21726627
Japanese Journal
- Processive phosphorylation of ERK MAP kinase in mammalian cells.
- Aoki Kazuhiro,Yamada Masashi,Kunida Katsuyuki,Yasuda Shuhei,Matsuda Michiyuki
- Proceedings of the National Academy of Sciences of the United States of America, 2011-07-18
- … 2011-07-19.The mitogen-activated protein (MAP) kinase pathway is comprised of a three-tiered kinase cascade. … The distributive kinetic mechanism of two-site MAP kinase phosphorylation inherently generates a nonlinear switch-like response. … However, a linear graded response of MAP kinase has also been observed in mammalian cells, and its molecular mechanism remains unclear. …
- NAID 120003204017
- Rosmarinus officinalis polyphenols activate cholinergic activities in PC12 cells through phosphorylation of ERK1/2
- Omri Abdelfatteh El,Han Junkyu,Yamada Parida,Kawada Kiyokazu,Abdrabbah Manef Ben,Isoda Hiroko,韓 畯奎,川田 清和,礒田 博子
- Journal of ethnopharmacology 131(2), 451-458, 2010-09
- … officinalis.Materials and methodsCell viability, cell differentiation, acetylcholinesterase (AChE) activity, total choline, acetylcholine (ACh) and extracellular signal-regulated kinases (ERK1/2) were determined in PC12 cells treated with extracts and HPLC-identified polyphenols of R. … U0126, inhibitor of ERK1/2, significantly reduced CA and RA effects on cell differentiation and AChE activity.ConclusionsR. …
- NAID 120002598875
Related Links
- 【発明の詳細な説明】 【技術分野】 【0001】 （発明の分野） 本発明は、マイトジェン活性化プロテインキナーゼ（MEKおよびMAPK／ERKキナーゼとしても知られている）[例えばマイトジェン活性化 ...
- 【発明の詳細な説明】 【技術分野】 【0001】 本発明は、マイトジェン活性化プロテインキナーゼ キナーゼ1（MAPKK1、MAPK／ERKキナーゼ1及びMEK1としても知られている）及びマイトジェン活性化 ...
Related Pictures
![MAPK phosphatases |[mdash]| regulating the](https://1mg.info/0/8/j/1918.jpg)
★リンクテーブル★
| リンク元 | 「mitogen-activated protein kinase kinase」「MAPK kinase」「MAPK-ERKキナーゼ」 |
| 拡張検索 | 「MAPK-ERK kinase 1」 |
| 関連記事 | 「ERK」「MAP」「ER」「MA」「kinase」 |
「mitogen-activated protein kinase kinase」
MAPキナーゼキナーゼ、マイトジェン活性化プロテインキナーゼキナーゼ
「MAPK kinase」
「MAPK-ERKキナーゼ」
「MAPK-ERK kinase 1」
「ERK」
- 同
- [[]] extracellular-signal-regulated kinase
- 関
- MAPキナーゼスーパーファミリーカスケード
- MAPKファミリーに含まれるERKファミリーを構成
- キナーゼサブドメインVIIIの活性化ループに存在するリン酸化部位の配列がTEY
- セリンスレオニンキナーゼ
- MAPKKであるMEK1,MEK2によってスレオニンとチロシン残基がリン酸化され、活性化される。
- ERK1/2の基質
- 転写因子：Elk-1, Ets1, Sapla, STAT
- キナーゼ：p90rsk(p90 ribosomal S6 kinase), MNK1/MNK2
- cPLA2
- EGF受容体
- Sos
- 細胞骨格構成タンパク質(Map2, Tau)
- 同
- extracellular-signal-regulated kinase
「MAP」
- 僧帽弁輪形成術 mitral annuloplasty
- Miller assessment for Pre-schoolers
- 平均動脈圧 mean arterial pressure
- 平均気道内圧 mean airway pressure
- mannitol adenine phosphate
- リン酸アンモニウムマグネシウム magnesium ammonium phosphate
「ER」
「MA」