リブマン・サックス心内膜炎
WordNet
- inflammation of the endocardium and heart valves
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/19 18:33:58」(JST)
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| Libman–Sacks endocarditis |
| Classification and external resources |
| ICD-10 |
I39, M32.1 |
| ICD-9 |
710.0 |
| DiseasesDB |
29254 |
| eMedicine |
med/1295 |
| MeSH |
D008180 |
Libman–Sacks endocarditis (often misspelled Libmann-Sachs) is a form of nonbacterial endocarditis that is seen in systemic lupus erythematosus. It is one of the most common cardiac manifestations of lupus (the most common being pericarditis).[1]
It was first described by Emanuel Libman and Benjamin Sacks at Mount Sinai Hospital in New York City in 1924.[2][3] The association between Libman–Sacks endocarditis and antiphospholipid syndrome was first noted in 1985.
Presentation
The vegetations are small and formed from strands of fibrin, neutrophils, lymphocytes, and histiocytes. The mitral valve is typically affected, and the vegetations occur on the ventricular and atrial surface of the valve. Libman-Sacks lesions rarely produce significant valve dysfunction and the lesions only rarely embolize.[4]
Pathology
The pathology is the same as nonbacterial thrombotic endocarditis except focal necrosis (hematoxylin bodies) can be found only in Libman–Sacks endocarditis.[citation needed]
References
- ^ "Libman-Sakcs endocarditis". Mosby’s Medical, Nursing & Allied Health Dictionary (Fourth ed.). Mosby-YearBook, Inc. 1994. p. 907.
- ^ Libman, E.; Sacks, B. (1924). "A hitherto undescribed form of valvular and mural endocarditis". Arch Intern Med 33 (6): 701–737. doi:10.1001/archinte.1924.00110300044002.
- ^ "Patient.co.uk: Libman-Sacks Endocarditis". Retrieved 2008-08-11.
- ^ Doherty, N. E.; Siegel, R. J. (1985). "Cardiovascular manifestations of systemic lupus erythematosus". Am Heart J 110 (6): 1257–1265. doi:10.1016/0002-8703(85)90023-7. PMID 3907317.
- Cardiovascular disease: heart disease
- Circulatory system pathology
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| Ischaemic |
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Coronary disease
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- Coronary artery disease (CAD)
- Coronary artery aneurysm
- Coronary artery dissection
- Coronary thrombosis
- Coronary vasospasm
- Myocardial bridge
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Active ischemia
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- Angina pectoris
- Prinzmetal's angina
- Stable angina
- Acute coronary syndrome
- Myocardial infarction
- Unstable angina
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Sequelae
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- hours
- Hibernating myocardium
- Myocardial stunning
- days
- weeks
- Aneurysm of heart / Ventricular aneurysm
- Dressler's syndrome
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| Layers |
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Pericardium
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- Pericarditis
- Acute
- Chronic / Constrictive
- Pericardial effusion
- Cardiac tamponade
- Hemopericardium
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Myocardium
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- Myocarditis
- Cardiomyopathy: Dilated (Alcoholic), Hypertrophic, and Restrictive
- Loeffler endocarditis
- Cardiac amyloidosis
- Endocardial fibroelastosis
- Arrhythmogenic right ventricular dysplasia
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Endocardium /
valves
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Endocarditis
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- infective endocarditis
- Subacute bacterial endocarditis
- non-infective endocarditis
- Libman–Sacks endocarditis
- Nonbacterial thrombotic endocarditis
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Valves
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- mitral
- regurgitation
- prolapse
- stenosis
- aortic
- tricuspid
- pulmonary
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Conduction /
arrhythmia |
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Bradycardia
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- Sinus bradycardia
- Sick sinus syndrome
- Heart block: Sinoatrial
- AV
- Intraventricular
- Bundle branch block
- Right
- Left
- Left anterior fascicle
- Left posterior fascicle
- Bifascicular
- Trifascicular
- Adams–Stokes syndrome
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Tachycardia
(paroxysmal and sinus)
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Supraventricular
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- Atrial
- Junctional
- AV nodal reentrant
- Junctional ectopic
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Ventricular
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- Accelerated idioventricular rhythm
- Catecholaminergic polymorphic
- Torsades de pointes
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Premature contraction
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Pre-excitation syndrome
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- Lown–Ganong–Levine
- Wolff–Parkinson–White
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Flutter / fibrillation
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- Atrial flutter
- Ventricular flutter
- Atrial fibrillation
- Ventricular fibrillation
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Pacemaker
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- Ectopic pacemaker / Ectopic beat
- Multifocal atrial tachycardia
- Pacemaker syndrome
- Parasystole
- Wandering pacemaker
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Long QT syndrome
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- Andersen–Tawil
- Jervell and Lange-Nielsen
- Romano–Ward
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Cardiac arrest
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- Sudden cardiac death
- Asystole
- Pulseless electrical activity
- Sinoatrial arrest
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Other / ungrouped
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- hexaxial reference system
- Right axis deviation
- Left axis deviation
- QT
- T
- ST
- Osborn wave
- ST elevation
- ST depression
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| Cardiomegaly |
- Ventricular hypertrophy
- Left
- Right / Cor pulmonale
- Atrial enlargement
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| Other |
- Cardiac fibrosis
- Heart failure
- Diastolic heart failure
- Cardiac asthma
- Rheumatic fever
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noco/cong/tumr, sysi/epon, injr
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proc, drug (C1A/1B/1C/1D), blte
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Systemic connective tissue disorders (M32–M36, 710)
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| General |
| Systemic lupus erythematosus: |
- Drug-induced SLE
- Libman-Sacks endocarditis
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| Inflammatory myopathy/Myositis: |
- Dermatopolymyositis
- Dermatomyositis/Juvenile dermatomyositis
- Polymyositis* Inclusion body myositis
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| Scleroderma: |
- Systemic scleroderma
- Progressive systemic sclerosis
- CREST syndrome
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- Overlap syndrome / Mixed connective tissue disease
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| Other hypersensitivity/autoimmune |
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| Other |
- Behçet's disease
- Polymyalgia rheumatica
- Eosinophilic fasciitis
- Eosinophilia–myalgia syndrome
- fibrillin
- Marfan syndrome
- Congenital contractural arachnodactyly
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anat (h/n, u, t/d, a/p, l)/phys/devp/hist
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noco (m, s, c)/cong (d)/tumr, sysi/epon, injr
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UpToDate Contents
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English Journal
- Insertion/deletion polymorphism of the angiotensin-converting enzyme gene in lupus nephritis among Mexicans.
- Topete-Reyes JF, Soto-Vargas J, Morán-Moguel MC, Dávalos-Rodríguez IP, Chávez-González EL, García-de la Torre I, Parra-Michel R, Medina-Pérez M, Jalomo-Martínez B, Salazar-Páramo M.SourceDoctorado en Inmunología, Departamento de Fisiología, CUCS, Universidad de Guadalajara , Guadalajara , Mexico.
- Immunopharmacology and immunotoxicology.Immunopharmacol Immunotoxicol.2013 Feb;35(1):174-80. doi: 10.3109/08923973.2012.739175.
- The angiotensin (Ang)-converting enzyme (ACE) insertion/deletion (I/D) polymorphism determines Ang II levels, but its relationship with lupus nephritis (LN) in different populations is controversial. Objective: To describe the allelic and genotypic distribution of the I/D polymorphism in Mexican m
- PMID 23137230
- Membrane-Bound Complement Regulatory Proteins as Biomarkers and Potential Therapeutic Targets for SLE.
- Das N, Biswas B, Khera R.SourceDepartment of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India, nibhriti@hotmail.com.
- Advances in experimental medicine and biology.Adv Exp Med Biol.2013;734:55-81.
- For the last two decades, there had been remarkable advancement in understanding the role of complement regulatory proteins in autoimmune disorders and importance of complement inhibitors as therapeutics. Systemic lupus erythematosus is a prototype of systemic autoimmune disorders. The disease, thou
- PMID 22990695
Japanese Journal
- 抗リン脂質抗体陽性SLEに血小板減少性紫斑病を合併したLibman-Sacks型心内膜炎の1手術例
- 吉川 雅治,川口 鎮,高野橋 暁,八神 啓,桑原 史明,平手 裕市,宮田 義弥
- 日本心臓血管外科学会雑誌 38(1), 67-70, 2009-01-15
- … 症を発症した際に,抗リン脂質抗体症候群と診断された.抗核抗体陽性,ループス型抗凝固因子陽性,抗カルジオリピン-β2グリコプロテインI抗体高値を示した.僧帽弁切除標本病理検査により典型的なLibman-Sacks型心内膜炎による弁変性と診断された.本症例では,抗リン脂質抗体症候群による血栓塞栓症素因と血小板減少性紫斑病による出血素因という相反する血液凝固異常が混在し,術前の病態把握,術中の …
- NAID 110007028520
- Perforated Mitral Valve Aneurysm Associated with Libman-Sacks Endocarditis
- Takayama Tomoyuki,Teramura Masanori,Sakai Hiroshi,Tamaki Shinji,Okabayashi Tabito,Kawashima Takeshi,Yamamoto Takashi,Horie Minoru,Suzuki Tomoaki,Asai Tohru
- Internal Medicine 47(18), 1605-1608, 2008
- … The perforation of a mitral valve aneurysm is a rare disease which induces acute mitral regurgitation and is usually induced by infective endocarditis; … however, in this case report, acute heart failure was caused by a perforated mitral valve aneurysm that was speculated to be due to Libman-Sacks endocarditis with systemic lupus erythematosis and secondary anti-phospholipid syndrome. …
- NAID 130000079661
Related Links
- 12 Apr 2012 ... Libman-Sacks endocarditis (otherwise known as verrucous, marantic, or nonbacterial thrombotic endocarditis) is the most characteristic cardiac manifestation of the autoimmune disease systemic lupus erythematosus. Libman ...
- Libman-Sacks endocarditis (often misspelled Libmann-Sachs) is a form of nonbacterial endocarditis that is seen in systemic lupus erythematosus. It is one of the most common cardiac manifestations of lupus (the most common being ...
Related Pictures
★リンクテーブル★
[★]
- 英
- Libman-Sacks endocarditis、LSE
- 同
- リブマン-サックス型心内膜炎、リブマン・ザックス心内膜炎、リブマン・ザックス病 Libman-Sacks disease、異型疣贅性心内膜炎
[show details]
病因
病理
- 三尖弁・僧帽弁に疣贅を生じ、内皮細胞下には類線維素壊死と細胞浸潤、また結合組織の増加が認められる。