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Comparative subproteome analysis of three representative Leptospira interrogans vaccine strains reveals cross-reactive antigens and novel virulence determinants.

Zeng LB1, Zhuang XR2, Huang LL2, Zhang YY3, Chen CY2, Dong K2, Zhang Y2, Cui ZL2, Ding XL2, Chang YF4, Guo XK5, Zhu YZ6.
Journal of proteomics.J Proteomics.2015 Jan 1;112:27-37. doi: 10.1016/j.jprot.2014.08.015. Epub 2014 Sep 6.
Pathogenic Leptospira spp. causes leptospirosis in China and throughout the world. Here, we have sequenced two L. interrogans moderately virulent vaccine strains JDL03 (serovar Canicola) and JDL10 (serovar Hebdomadis) used in China. We selected a subproteomic approach to identify surface-exposed pro
PMID 25201075

Comparison of Bacterial Burden and Cytokine Gene Expression in Golden Hamsters in Early Phase of Infection with Two Different Strains of Leptospira interrogans.

Fujita R1, Koizumi N2, Sugiyama H3, Tomizawa R1, Sato R4, Ohnishi M2.
PloS one.PLoS One.2015 Jul 6;10(7):e0132694. doi: 10.1371/journal.pone.0132694. eCollection 2015.
Leptospirosis, a zoonotic infection with worldwide prevalence, is caused by pathogenic spirochaetes of Leptospira spp., and exhibits an extremely broad clinical spectrum in human patients. Although previous studies indicated that specific serovars or genotypes of Leptospira spp. were associated with
PMID 26146835

Leptospire genomic diversity revealed by microarray-based comparative genomic hybridization.

Eribo B1, Mingmongkolchai S, Yan T, Dubbs P, Nelson KE.
Applied and environmental microbiology.Appl Environ Microbiol.2012 May;78(9):3045-50. doi: 10.1128/AEM.07465-11. Epub 2012 Feb 17.
Comparative genomic hybridization was used to compare genetic diversity of five strains of Leptospira (Leptospira interrogans serovars Bratislava, Canicola, and Hebdomadis and Leptospira kirschneri serovars Cynopteri and Grippotyphosa). The array was designed based on two available sequenced Leptosp
PMID 22344655

Leptospira interrogans serovar Hebdomadisによる豚異常産事例 (日本獣医師会学会学術誌) -- (産業動物臨床・家畜衛生関連部門)

中尾聡子,荒木美穂,池宮城一文 [他]
日本獣医師会雑誌 = Journal of the Japan Veterinary Medical Association 67(12), 908-913, 2014-12
NAID 40020310069

Nationwide Survey of Leptospira Antibodies in Dogs in Japan: Results from Microscopic Agglutination Test and Enzyme-Linked Immunosorbent Assay

Iwamoto Emiko,Wada Yuko,Fujisaki Yuka [他],UMEKI Saori,JONES Miyuki Y.,MIZUNO Takuya,ITAMOTO Kazuhito,MAEDA Ken,IWATA Hiroyuki,OKUDA Masaru
Journal of Veterinary Medical Science 71(9), 1191-1199, 2009
… Leptospirosis is an infectious disease caused by Leptospira interrogans sensu lato and is common in both humans and animals. … interrogans serovars (Icterohaemorrhagiae, Canicola, Autumnalis, Hebdomadis, and Australis) as antigens, and an enzyme-linked immunosorbent assay (ELISA) using recombinant OmpL1 protein as the antigen. … The most commonly detected serovar was Icterohaemorrhagiae (22 dogs, 19 prefectures). …
NAID 130000134477

Koizumi Nobuo,Uchida Masaki,Makino Takashi [他],TAGURI Toshitsugu,KUROKI Toshiro,MUTO Maki,KATO Yukio,WATANABE Haruo
Journal of Veterinary Medical Science 71(4), 425-429, 2009
… Leptospira was isolated from 2 of 71 raccoons captured in Kanagawa Prefecture and 1 of 53 raccoons at a zoological park in Nagasaki Prefecture. … Anti-Leptospira antibodies were detected in 16 of 124 raccoons (12.9%) in Kanagawa and 33 of 53 raccoons (62.3%) in Nagasaki, respectively. … interrogans. …
NAID 130000134341