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flagellate protozoan that causes leishmaniasis (同)genus Leishmania

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/26 13:41:30」(JST)

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1. 皮膚リーシュマニア症の臨床症状および診断 clinical manifestations and diagnosis of cutaneous leishmaniasis
2. 皮膚リーシュマニア症の治療 treatment of cutaneous leishmaniasis
3. 皮膚リーシュマニア症の疫学およびマネージメント epidemiology and control of cutaneous leishmaniasis
4. 慢性腎臓病患者における骨粗鬆症：診断、評価およびマネージメント osteoporosis in patients with chronic kidney disease diagnosis evaluation and management
5. 非心不全下におけるナトリウム利尿ペプチド測定 natriuretic peptide measurement in non heart failure settings

English Journal

Leishmania braziliensis amastigotes stimulate production of IL-1β, IL-6, IL-10 and TGF-β by peripheral blood mononuclear cells from nonendemic area healthy residents.

Gomes CM1, Avila LR, Pinto SA, Duarte FB, Pereira LI, Abrahamsohn IA, Dorta ML, Vieira LQ, Ribeiro-Dias F, Oliveira MA.Author information 1Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brasil.AbstractLeishmania (Viannia) braziliensis causes cutaneous and mucosal leishmaniasis in several countries in Latin America. In mammals, the parasites live as amastigotes, interacting with host immune cells and stimulating cytokine production that will drive the type of the specific immune responses. Generation of Th17 lymphocytes is associated with tissue destruction and depends on IL-1β, IL-6, TGF-β and IL-23 production, whereas IL-10 and TGF-β are associated with tissue protection. Here, we evaluate whether amastigotes stimulate peripheral blood mononuclear cells (PBMCs) from healthy donors to produce the major cytokines responsible for the generation of Th17. Seven L. (V.) braziliensis isolates from patients with different clinical forms of leishmaniasis were expanded in interferon-γ knockout mice to obtain amastigotes and in culture to get promastigotes. The parasites were used to stimulate PBMCs from healthy donors, and cytokine production was evaluated by ELISA or qPCR. Amastigotes and promastigotes induced IL-10 production in PBMCs; however, only amastigotes induced IL-1β, IL-6 and TGF-β. These data demonstrate for the first time that L. (V.) braziliensis amastigotes directly stimulate production of a unique pattern of cytokines that could contribute to the generation of Th17.
Parasite immunology.Parasite Immunol.2014 May;36(5):225-31. doi: 10.1111/pim.12109.
Leishmania (Viannia) braziliensis causes cutaneous and mucosal leishmaniasis in several countries in Latin America. In mammals, the parasites live as amastigotes, interacting with host immune cells and stimulating cytokine production that will drive the type of the specific immune responses. Generat
PMID 24575815

In vitro cytokines profile and ultrastructural changes of microglia and macrophages following interaction with Leishmania.

Ramos PK1, Brito MD2, Silveira FT1, Salgado CG3, DE Souza W4, Picanço-Diniz CW5, Picanço-Diniz JA2.Author information 1Instituto Evandro Chagas, Programa de Leishmanioses, Rod. BR-316, km 07, Bairro Levilândia, 67030-000, Ananindeua, Pará, Brazil.2Laboratório de Microscopia Eletrônica, Instituto Evandro Chagas, Av. Almirante Barroso 492, Bairro Marco, 66090-000, Belém, Pará, Brazil.3Laboratório de Dermato-Imunologia, Universidade do Estado do Pará (UEPA), Universidade Federal do Pará (UFPA), Unidade de Referência em Dermatologia Sanitária do Estado do Pará 'Dr. Marcello Candia' (MC), Brazil.4Laboratório de Ultraestrutura Celular Hertha Meyer, Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, Ilha do Fundão, Rio de Janeiro, RJ, Brazil.5Laboratório de Investigações em Neurodegeneração e Infecção, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, Brazil.AbstractSUMMARY In the present study, we assessed morphological changes and cytokine production after in vitro interaction with causative agents of American cutaneous leishmaniasis and compared the microglia and macrophage immune responses. Cultures of microglia and macrophages infected with stationary-phase promastigotes of Leishmania (Viannia) shawi, Leishmania (Viannia) braziliensis or Leishmania (Leishmania) amazonensis were evaluated 24, 48 and 72 h after interaction. Macrophages only presented the classical phagocytic process while microglia also displayed large cytoplasmic projections similar to the ruffles described in macropinocytosis. In the macrophage cultures, the percentage of infected cells increased over time, in a fashion that was dependent on the parasite species. In contrast, in microglial cells as the culture time progressed, there was a significant reduction in the percentage of infected cells independent of parasite species. Measurements of cytokines in macrophage cultures 48 h after interactions revealed distinct expression patterns for different parasites, whereas in microglial cultures they were similar for all Leishmania tested species. Taken together, our results suggest that microglia may have a higher phagocytic ability and cytotoxic potential than macrophages for all investigated species. The robust response of microglia against all parasite species may suggest microglia have an important role in the defence against cerebral leishmaniasis.
Parasitology.Parasitology.2014 Apr 9:1-12. [Epub ahead of print]
SUMMARY In the present study, we assessed morphological changes and cytokine production after in vitro interaction with causative agents of American cutaneous leishmaniasis and compared the microglia and macrophage immune responses. Cultures of microglia and macrophages infected with stationary-phas
PMID 24717447

Erythema exsudativum multiforme after a leishmania skin test.

Wind BS1, Guimarães LH, Machado PR.Author information 1Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Rua João das Botas S/N, Canela, Salvador; Universidade Federal da Bahia, Salvador, Bahia, Brazil.AbstractAbstract. A 45-year-old otherwise healthy male from an endemic region for Leishmania braziliensis infection in Bahia, Brazil, presented with three erosive hemorrhagic infiltrated plaques on the left shin accompanied with lymphadenopathy in the groin since one month (Figure 1). A Leishmania skin test performed on the left forearm was strongly positive (20 × 18 mm).1 Two days later, the patient felt sick and feverish. Painful erythematous target lesions developed on the palms and scapula together with conjunctivitis (Figure 2). Histopathology confirmed erythema exsudativum multiforme (EEM) (Figure 3). Both EEM and cutaneous leishmaniasis were successfully treated with a 5-day course of prednisone 20 mg, and a 20-day course of intravenous pentavalent antimony, respectively.
The American journal of tropical medicine and hygiene.Am J Trop Med Hyg.2014 Apr;90(4):587-8. doi: 10.4269/ajtmh.13-0166.
Abstract. A 45-year-old otherwise healthy male from an endemic region for Leishmania braziliensis infection in Bahia, Brazil, presented with three erosive hemorrhagic infiltrated plaques on the left shin accompanied with lymphadenopathy in the groin since one month (Figure 1). A Leishmania skin test
PMID 24696403

Japanese Journal

Leishmania species identification using FTA card sampling directly from patients' cutaneous lesions in the state of Lara, Venezuela

Kato Hirotomo,Watanabe Junko,Mendoza Nieto Iraida,Korenaga Masataka,Hashiguchi Yoshihisa
Transactions of the Royal Society of Tropical Medicine and Hygiene 105(10), 561-567, 2011-10
… A molecular epidemiological study was performed using FTA card materials directly sampled from lesions of patients with cutaneous leishmaniasis (CL) in the state of Lara, Venezuela, where causative agents have been identified as Leishmania (Viannia) braziliensis and L. … (Leishmania) venezuelensis in the past studies. …
NAID 120003464636

Leishmania (Viannia) braziliensis transfectants overexpressing the miniexon gene lose virulence in vivo

DE TOLEDO Juliano Simoes,DOS SANTOS Andre F. Junqueira,DE MOURA Tatiana Rodrigues,ANTONIAZI Simone Aparecida,BRODSKYN Claudia,DE OLIVEIRA Camila Indiani,BARRAL Aldina,CRUZ Angela Kaysel
Parasitology international : official journal of the Japanese Society of Parasitology 58(1), 45-50, 2009-03-01
NAID 10025330038

In Vitro Antiproliferative Effects of Several Diaryl Derivatives on Leishmania spp

Alves Luciana Vignolio,Do Canto-Cavalheiro Marilene Marcuzzo,Cysne-Finkelstein Lea [他],LEON Leonor
Biological & pharmaceutical bulletin 26(4), 453-456, 2003-04-01
… These drugs were assayed against Leishmania amazonensis, L. … braziliensis and L. …
NAID 110003608453